Abstract: A method of operating an articulatable surgical instrument. The method includes providing a rotary drive motion to a rotary drive member of a surgical end effector and converting the rotary drive motion to an upper axial motion and a lower axial motion at locations that are distal to the articulation joint. The method further includes applying the upper axial motion to an upper portion of a firing member and applying the lower axial motion to a lower portion of the firing member such that the upper axial motion and lower axial motion drives the firing member distally through the surgical end effector from a starting position to an ending position.

Abstract: Systems, devices, and methods are provided for generating NO and delivering NO in controlled amounts. A system for generating nitric oxide (NO) is provided, and in some embodiments can include a converter configured to convert a source material to a NO-containing gas, at least one controller configured to independently control a conversion of the source material to the NO-containing gas and a delivery of the NO-containing gas to an inspiratory pathway, and one or more sensors configured to communicate, to the at least one controller, information related to the conversion of the source material to the NO-containing gas.

Abstract: Architectures for production of nitric oxide (NO) include systems and methods for generating NO having one or more plasma chambers configured to ionize a reactant gas to generate a plasma for producing a product gas containing NO using a flow of the reactant gas through one or more plasma chambers; a controller configured to regulate the amount of nitric oxide in the product gas using one or more parameters as an input to the controller, one or more parameters including information from a plurality of sensors configured to collect information relating to at least one of the reactant gas, the product gas, and a medical gas into which product gas flows; and a flow divider configured to divide a product gas flow from the plasma chamber into a first product gas flow to provide a variable flow to a patient inspiratory flow and a second product gas flow.

Abstract: The present invention provides compounds of formula I wherein R1, R2 or R3 are as described herein, as well as pharmaceutically acceptable salts thereof. Further the present invention is concerned with the manufacture of the compounds of formula I, pharmaceutical compositions comprising them and their use as medicaments.