Patents by Inventor Benjamin J. Huffman

Benjamin J. Huffman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOUNDS, COMPOSITIONS, AND METHODS
    Publication number: 20260200891
    Abstract: The present disclosure relates generally to small molecule modulators of ion channels (TMEM-175) and their use as therapeutic agents.
    Type: Application
    Filed: November 17, 2023
    Publication date: July 16, 2026
    Inventors: Alex L. Bagdasarian, Cyril Bucher, Anthony A. Estrada, Brian M. Fox, Benjamin J. Huffman, Katrina W. Lexa, Maksim Osipov, Hengameh Shams, Arun Thottumkara, John C. Widen
  • COMPOUNDS, COMPOSITIONS, AND METHODS
    Publication number: 20260193243
    Abstract: The present disclosure relates generally to small molecule modulators of ion channels and their use as therapeutic agents.
    Type: Application
    Filed: November 17, 2023
    Publication date: July 9, 2026
    Inventors: Lydia A. Auch, Alex L. Bagdasarian, Cyril Bucher, Javier De Vicente Fidalgo, Anthony A. Estrada, Brian M. Fox, Benjamin J. Huffman, Katrina W. Lexa, Maksim Osipov, Hengameh Shams, Arun Thottumkara, John C. Widen
  • COMPOUNDS, COMPOSITIONS, AND METHODS
    Publication number: 20250361234
    Abstract: The present disclosure relates generally to small molecule inhibitors of Sterile Alpha and TIR Motif containing 1 (SARM1) protein, or a pharmaceutically acceptable salt, isotopically enriched analog, stereoisomer, mixture of stereoisomers, or pro-drug thereof, methods of making and intermediates thereof, and methods of using thereof.
    Type: Application
    Filed: June 6, 2023
    Publication date: November 27, 2025
    Inventors: Lydia A. Auch, Alex L. Bagdasarian, Cyril Bucher, Robert A. Craig, II, Javier de Vicente Fidalgo, Anthony A. Estrada, Brian M. Fox, Benjamin J. Huffman, Katrina W. Lexa, Takashi Miyamoto, Maksim Osipov, Arun Thottumkara
  • COMPOUNDS, COMPOSITIONS, AND METHODS
    Publication number: 20250197399
    Abstract: The present disclosure relates generally to small molecule modulators of NLR Family Pyrin Domain Containing 3 (NL-RP3), or a pharmaceutically acceptable salt, isotopically enriched analog, stereoisomer, mixture of stereoisomers, or prodrug thereof, methods of making and intermediates thereof, and methods of using thereof.
    Type: Application
    Filed: March 29, 2023
    Publication date: June 19, 2025
    Inventors: Alex L. Bagdasarian, Cyril Bucher, Robert A. Craig, II, Javier de Vicente Fidalgo, Anthony A. Estrada, Brian M. Fox, Benjamin J. Huffman, Katrina W. Lexa, Maksim Osipov
  • COMPOUNDS, COMPOSITIONS, AND METHODS
    Publication number: 20250171462
    Abstract: The present disclosure relates generally to small molecule inhibitors of Sterile Alpha and TIR Motif containing 1 (SARM1) protein, or a pharmaceutically acceptable salt, isotopically enriched analog, stereoisomer, mixture of stereoisomers, or prodrug thereof, methods of making and intermediates thereof, and methods of using thereof.
    Type: Application
    Filed: March 1, 2023
    Publication date: May 29, 2025
    Inventors: Lydia A. Auch, Alex L. Bagdasarian, Cyril Bucher, Robert A. Craig, II, Javier de Vicente Fidalgo, Anthony A. Estrada, Brian M. Fox, Benjamin J. Huffman, Katrina W. Lexa, Takashi Miyamoto, Maksim Osipov, Arun Thottumkara
  • COMPOUNDS, COMPOSITIONS, AND METHODS
    Publication number: 20250145592
    Abstract: The present disclosure relates generally to small molecule modulators of NLR Family Pyrin Domain Containing 3 (NL-RP3), or a pharmaceutically acceptable salt, isotopically enriched analog, stereoisomer, mixture of stereoisomers, or prodrug thereof, methods of making and intermediates thereof, and methods of using thereof. Further disclosed a method for treating a disease or condition mediated, at least in part, by NLRP3, the method comprising administering an effective amount of the pharmaceutical composition, to a subject in need thereof.
    Type: Application
    Filed: February 15, 2023
    Publication date: May 8, 2025
    Inventors: Alex L. Bagdasarian, Robert A. Craig, II, Javier de Vicente Fidalgo, Anthony A. Estrada, Brian M. Fox, Cheng Hu, Benjamin J. Huffman, Katrina W. Lexa, Lizanne G. Nilewski, Maksim Osipov, Arun Thottumkara
  • COMPOUNDS, COMPOSITIONS AND METHODS
    Publication number: 20240254132
    Abstract: The present disclosure relates generally to small molecule modulators of NLR Family Pyrin Domain Containing 3 (NL-RP3), or a pharmaceutically acceptable salt, isotopically enriched analog, stereoisomer, mixture of stereoisomers, or prodrug thereof, methods of making and intermediates thereof, and methods of using thereof.
    Type: Application
    Filed: July 15, 2022
    Publication date: August 1, 2024
    Inventors: Alex L. Bagdasarian, Robert A. Craig, II, Javier de Vicente Fidalgo, Anthony A. Estrada, Benjamin J. Huffman, Katrina W. Lexa, Maksim Osipov, Arun Thottumkara
  • COMPOUNDS, COMPOSITIONS, AND METHODS
    Publication number: 20230416205
    Abstract: The present disclosure relates generally to small molecule modulators of NLR Family Pyrin Domain Containing 3 (NL-RP3), or a pharmaceutically acceptable salt, isotopically enriched analog, stereoisomer, mixture of stereoisomers, or prodrug thereof, methods of making and intermediates thereof, and methods of using thereof.
    Type: Application
    Filed: November 19, 2021
    Publication date: December 28, 2023
    Inventors: Alex L. Bagdasarian, Cyril Bucher, Robert A. Craig, II, Javier de Vicente Fidalgo, Anthony A. Estrada, Brian M. Fox, Cheng Hu, Benjamin J. Huffman, Katrina W. Lexa, Lizanne G. Nilewski, Maksim Osipov, Arun Thottumkara
  • COMPOUNDS, COMPOSITIONS AND METHODS
    Publication number: 20230357162
    Abstract: The present disclosure relates generally to small molecule modulators of NLR Family Pyrin Domain Containing 3 (NL-RP3), or a pharmaceutically acceptable salt, isotopically enriched analog, stereoisomer, mixture of stereoisomers, or prodrug thereof, methods of making and intermediates thereof, and methods of using thereof.
    Type: Application
    Filed: August 13, 2021
    Publication date: November 9, 2023
    Inventors: Alex L. Bagdasarian, Robert A. Craig, II, Javier de Vicente Fidalgo, Anthony A. Estrada, Brian M. Fox, Cheng Hu, Benjamin J. Huffman, Katrina W. Lexa, Lizanne G. Nilewski, Maksim Osipov, Arun Thottumkara