Abstract: Provided herein are imaging agent-loaded cryopreserved platelets and platelet derivatives, such as MRI agent-loaded platelets and platelet derivatives, and methods of preparing and using the same. In some embodiments, methods of loading MRI agents into platelets include contacting platelets with an MRI agent and a cell penetrating peptide. In some embodiments, methods of preparing MRI agent-loaded cryopreserved platelets or platelet derivatives in a dried powder, wherein the MRI agent-loaded cryopreserved platelets or the MRI agent-loaded platelet derivatives comprise an MRI agent complex covalently bonded to the surface of the cryopreserved platelets or the platelet derivatives.

Abstract: Provided herein are methods for administering platelet derivatives, such as freeze-dried platelet derivatives (FDPDs) to a subject, comprising administering an effective dose of the platelet derivatives in a platelet derivative composition to the subject. Such effective dose in illustrative embodiments, includes multiple individual doses, or a continuous dose administered within a time period, for example a time period of less than 4 hours. In certain aspects herein the subject is a subject having Hermansky Pudlak Syndrome (HPS). The platelet derivatives can have numerous characteristics provided herein that make them well suited to restore hemostatic functions in the subject. In some embodiments, the platelet derivatives are from a pool of donors, and are HLA Class 1-characterized platelet derivatives (e.g., FDPDs), which in certain illustrative embodiments are HLA Class 1-matched FDPDs.

Abstract: Provided herein are methods and compositions using extracellular vesicles derived from fresh, frozen, or lyophilized platelets.

Abstract: Provided herein in some embodiments is a method of preparing a plasma product, including providing plasma, acidifying the plasma to form acidified plasma, drying the acidified plasma to form dried plasma, and milling the dried plasma to form a plasma product. Also provided are plasma products produced by the methods described herein.

Abstract: This disclosure relates to a composition that, in some embodiments, includes cryopreserved platelets; and a cryoprotectant, wherein the composition comprises less than 6% (v/v) of dimethyl sulfoxide (DMSO). In some embodiments, the composition is substantially free of dimethyl sulfoxide (DMSO).

Abstract: A job completion architecture, includes content that is specified as a hierarchical tree of related content units and a set of multilevel tickets associated with instances of the hierarchically arranged content units. The job manager applies the multilevel tickets, specifying property settings at potentially multiple levels within the hierarchical tree, according to a qualified inheritance rule wherein settings applicable to a set of lower level properties that are specified within a first (higher level) ticket are incorporated into the merged settings to the extent a second (lower level) ticket does not specify settings for the set of lower level properties. If a same property is specified in both a higher and lower level ticket, during merging a setting specified in the lower level ticket overrides the higher level ticket setting.

Abstract: Systems and methods relating to notebook computers providing enhanced display features are described. In one instance, an exemplary notebook computer includes a housing. The housing includes a base that has a keyboard positioned on the base. The housing also includes a lid attached to the base via a hinge means and configured to swing from a transport-position against the keyboard to a user-position away from the keyboard. The notebook computer also includes a first display device positioned on the lid and generally opposing the keyboard. The notebook computer further includes a second optionally-deployable display device attached to the notebook computer and configured to deploy from a first storage-position to a second user-position in which the second optionally-deployable display device is configured to collectively create a user workspace with the first display device for a user positioned in front of the keyboard and generally opposite the hinge means.