Patents by Inventor Benjamin J. Littler

Benjamin J. Littler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PROCESSES FOR MAKING MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR
    Publication number: 20240025877
    Abstract: The disclosure provides processes for preparing a compound of Formula (I):
    Type: Application
    Filed: August 31, 2022
    Publication date: January 25, 2024
    Inventors: Paul T. Angell, Cristian Harrison, Robert M. Hughes, Berenice Lewandowski, Benjamin J. Littler, Vito Melillo, William A. Nugent, David Andrew Siesel, David Smith, John Studley
  • PROCESS OF MAKING CFTR MODULATORS
    Publication number: 20230399343
    Abstract: The disclosure provides processes for synthesizing Compound I, and pharmaceutically acceptable salts thereof.
    Type: Application
    Filed: January 4, 2023
    Publication date: December 14, 2023
    Inventors: Paul Angell, John E. Cochran, Benjamin J. Littler, David Siesel, Armando Urbina, Corey Don Anderson, Jeremy J. Clemens, Thomas Cleveland, Timothy Richard Coon, Bryan Frieman, Peter Grootenhuis, Sara Sabina Hadida Ruah, Jason McCartney, Mark Thomas Miller, Prasuna Paraselli, Fabrice Pierre, Sara E. Swift, Jinglan Zhou
  • Process of making CFTR modulators
    Patent number: 11584761
    Abstract: The disclosure provides processes for synthesizing Compound I, and pharmaceutically acceptable salts thereof.
    Type: Grant
    Filed: August 13, 2020
    Date of Patent: February 21, 2023
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Paul Angell, John E. Cochran, Benjamin J. Littler, David Siesel, Armando Urbina, Corey Don Anderson, Jeremy J. Clemens, Thomas Cleveland, Timothy Richard Coon, Bryan Frieman, Peter Grootenhuis, Sara Sabina Hadida Ruah, Jason McCartney, Mark Thomas Miller, Prasuna Paraselli, Fabrice Pierre, Sara E. Swift, Jinglan Zhou
  • Processes for making modulators of cystic fibrosis transmembrane conductance regulator
    Patent number: 11465985
    Abstract: The disclosure provides processes for preparing a compound of Formula (I).
    Type: Grant
    Filed: December 7, 2018
    Date of Patent: October 11, 2022
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Paul T. Angell, Cristian Harrison, Robert M. Hughes, Berenice Lewandowski, Benjamin J. Littler, Vito Melillo, William A. Nugent, David Andrew Siesel, David Smith, John Studley
  • Processes for preparing pyrrolidine compounds
    Patent number: 11434201
    Abstract: Processes for preparing 5,5-dimethyl-3-methylenepyrrolidin-2-one, (S)-3,5,5-trimethylpyrrolidine-2-one, (R)-3,5,5-trimethylpyrrolidine-2-one, (S)-2,4,4-trimethylpyrrolidine, and (R)-2,4,4-trimethylpyrrolidine, and their salt forms are disclosed.
    Type: Grant
    Filed: August 2, 2018
    Date of Patent: September 6, 2022
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Paul T. Angell, Robert M. Hughes, Berenice Lewandowski, Benjamin J. Littler, William A. Nugent, David Smith, John Studley
  • PROCESSES FOR MAKING MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR
    Publication number: 20210246117
    Abstract: The disclosure provides processes for preparing a compound of Formula (I).
    Type: Application
    Filed: December 7, 2018
    Publication date: August 12, 2021
    Inventors: Paul T. Angell, Cristian Harrison, Robert M. Hughes, Berenice Lewandowski, Benjamin J. Littler, Vito Melillo, William A. Nugent, David Andrew Siesel, David Smith, John Studley
  • PROCESS OF MAKING CFTR MODULATORS
    Publication number: 20210047345
    Abstract: The disclosure provides processes for synthesizing Compound I, and pharmaceutically acceptable salts thereof.
    Type: Application
    Filed: August 13, 2020
    Publication date: February 18, 2021
    Inventors: Paul Angell, John E. Cochran, Benjamin J. Littler, David Siesel, Armando Urbina, Corey Don Anderson, Jeremy J. Clemens, Thomas Cleveland, Timothy Richard Coon, Bryan Frieman, Peter Grootenhuis, Sara Sabina Hadida Ruah, Jason McCartney, Mark Thomas Miller, Prasuna Paraselli, Fabrice Pierre, Sara E. Swift, Jinglan Zhou
  • PROCESSES FOR PREPARING PYRROLIDINE COMPOUNDS
    Publication number: 20200369608
    Abstract: Processes for preparing 5,5-dimethyl-3-methylenepyrrolidin-2-one, (S)-3,5,5-trimethylpyrrolidine-2-one, (R)-3,5,5-trimethylpyrrolidine-2-one, (S)-2,4,4-trimethylpyrrolidine, and (R)-2,4,4-trimethylpyrrolidine, and their salt forms are disclosed.
    Type: Application
    Filed: August 2, 2018
    Publication date: November 26, 2020
    Inventors: Paul T. Angell, Robert M. Hughes, Berenice Lewandowski, Benjamin J. Littler, William A. Nugent, David Smith, John Studley
  • Process for production of piperidine derivatives
    Patent number: 8067605
    Abstract: Processes are disclosed for preparing piperidine derivative compounds of the formulae I, II or III: The processes involve reacting a compound of formula Ia, IIa or IIIa with isobutyrate or an isobutyrate equivalent.
    Type: Grant
    Filed: November 30, 2010
    Date of Patent: November 29, 2011
    Assignee: Albany Molecular Research, Inc.
    Inventors: Harold Meckler, Benjamin J. Littler, Prasad Raje, Michael Van Brundt, Paul Vogt
  • PROCESS FOR PRODUCTION OF CAREBASTINE
    Publication number: 20110065923
    Abstract: Processes are disclosed for preparing piperidine derivative compounds of the formulae I, II or III:
    Type: Application
    Filed: November 22, 2010
    Publication date: March 17, 2011
    Applicant: Albany Molecular Research, Inc.
    Inventors: Harold MECKLER, Benjamin J. Littler, Prasad Raje, Michael van Brunt, Paul F. Vogt
  • PROCESS FOR PRODUCTION OF CAREBASTINE
    Publication number: 20090137813
    Abstract: Processes are disclosed for preparing piperidine derivative compounds of the formulae I, II or III:
    Type: Application
    Filed: January 20, 2009
    Publication date: May 28, 2009
    Applicant: ALBANY MOLECULAR RESEARCH, INC.
    Inventors: Harold Meckler, Benjamin J. Littler, Prasad Raje, Michael Van Brunt, Paul F. Vogt
  • Process for production of piperidine derivatives
    Patent number: 7498345
    Abstract: Processes are disclosed for preparing piperidine derivative compounds of the formulae I, II or III: The processes involve reacting a compound of formula Ia, IIa or IIIa with isobutyrate or an isobutyrate equivalent.
    Type: Grant
    Filed: September 17, 2004
    Date of Patent: March 3, 2009
    Assignee: Albany Molecular Research, Inc.
    Inventors: Harold Meckler, Benjamin J. Littler, Prasad Raje, Michael Van Brunt, Paul F. Vogt
  • Process for production of carebastine
    Patent number: 7498443
    Abstract: Processes are disclosed for preparing piperidine derivative compounds of the formulae I, II or III:
    Type: Grant
    Filed: September 17, 2004
    Date of Patent: March 3, 2009
    Assignee: Albany Molecular Research, Inc.
    Inventors: Harold Meckler, Benjamin J. Littler, Prasad Raje, Michael Van Brunt, Paul F. Vogt