Patents by Inventor Benjamin J. Luft

Benjamin J. Luft has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Recombinant constructs of borrelia burgdorferi
    Publication number: 20040033236
    Abstract: Novel chimeric nucleic acids, encoding chimeric Borrelia proteins comprising OspC or an antigenic fragment thereof and OspA or an antigenic fragment thereof, are disclosed. Chimeric proteins encoded by the nucleic acid sequences are also disclosed. The chimeric proteins are useful as vaccine immunogens against Lyme borreliosis, as well as for immunodiagnostic reagents.
    Type: Application
    Filed: February 18, 2003
    Publication date: February 19, 2004
    Applicants: Research Foundation of State University of New York, Brookhaven Sciences Associates, LLC
    Inventors: Raymond J. Dattwyler, Maria J. C. Gomes-Solecki, Benjamin J. Luft, John J. Dunn
  • Altered OspA of Borrelia burgdorferi
    Publication number: 20040023325
    Abstract: Provided herein are OspA polypeptides from Lyme Disease-causing Borrelia having certain alteration(s). In one embodiment, the alteration(s) increase the conformational stability of the OspA polypeptide containing the alteration(s) while maintaining at least some of the antigenicity of the corresponding unaltered OspA polypeptide. In another embodiment, the altered OspA polypeptide has reduced cross-reactivity to hLFA-1, as compared to the corresponding unaltered OspA polypeptide.
    Type: Application
    Filed: February 18, 2003
    Publication date: February 5, 2004
    Applicants: Research Foundation of the State University of New York, Brookhaven Sciences Associates, LLC, University of Rochester
    Inventors: Benjamin J. Luft, John J. Dunn, Shohei Koide, Catherine L. Lawson
  • Chimeric proteins comprising borrelia polypeptides and uses therefor
    Patent number: 6248562
    Abstract: Chimeric nucleic acids encoding chimeric Borrelia proteins consisting of at least two antigenic polypeptides from corresponding and/or non-corresponding proteins from the same and/or different species of Borrelia, are disclosed. Chimeric proteins encoded by the nucleic acid sequences are also disclosed. The chimeric proteins are useful as vaccine immunogens against Lyme borreliosis, as well as for immunodiagnostic reagents.
    Type: Grant
    Filed: April 29, 1994
    Date of Patent: June 19, 2001
    Assignees: Research Foundation State University of New York, Brookhaven Science Associates
    Inventors: John J. Dunn, Benjamin J. Luft