Patents by Inventor Benjamin J. Pavlik

Benjamin J. Pavlik has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Engineered clostridium botulinum toxin adapted to deliver molecules into selected cells
    Patent number: 11118170
    Abstract: An engineered payload-delivery system includes a target cell binding unit, covalently bound to a pore forming unit, and a payload portion adapted with a region capable of non-covalently binding to the pore forming unit. The pore forming unit is derived from a particular sub-serotype of Clostridium toxin, while the payload region is derived from a different sub-serotype of Clostridium toxin. The disclosed chimeric protein-based composition is capable of specifically delivering payload to neural cells.
    Type: Grant
    Filed: April 21, 2020
    Date of Patent: September 14, 2021
    Assignee: The Board of Regents of the University of Nebraska
    Inventors: Benjamin J. Pavlik, Paul Blum, Kevin Van Cott
  • Engineered Clostridium Botulinum Toxin Adapted To Deliver Molecules Into Selected Cells
    Publication number: 20200255815
    Abstract: An engineered payload-delivery system includes a target cell binding unit, covalently bound to a pore forming unit, and a payload portion adapted with a region capable of non-covalently binding to the pore forming unit. The pore forming unit is derived from a particular sub-serotype of Clostridium toxin, while the payload region is derived from a different sub-serotype of Clostridium toxin. The disclosed chimeric protein-based composition is capable of specifically delivering payload to neural cells.
    Type: Application
    Filed: April 21, 2020
    Publication date: August 13, 2020
    Inventors: Benjamin J. Pavlik, Paul Blum, Kevin Van Cott
  • Engineered toxin adapted to deliver molecules into selected cells
    Patent number: 10633643
    Abstract: An engineered payload-delivery system includes a target cell binding unit, covalently bound to a pore forming unit, and a payload portion adapted with a region capable of non-covalently binding to the pore forming unit. The pore forming unit is derived from a particular sub-serotype of Clostridium toxin, while the payload region is derived from a different sub-serotype of Clostridium toxin. The disclosed chimeric protein-based composition is capable of specifically delivering payload to neural cells.
    Type: Grant
    Filed: May 14, 2016
    Date of Patent: April 28, 2020
    Assignee: Board of Regents of the University of Nebraska
    Inventors: Benjamin J. Pavlik, Paul Blum, Kevin Van Cott
  • Engineered Clostridium Botulinum Toxin Adapted To Deliver Molecules Into Selected Cells
    Publication number: 20180127734
    Abstract: An engineered payload-delivery system includes a target cell binding unit, covalently bound to a pore forming unit, and a payload portion adapted with a region capable of non-covalently binding to the pore forming unit. The pore forming unit is derived from a particular sub-serotype of Clostridium toxin, while the payload region is derived from a different sub-serotype of Clostridium toxin. The disclosed chimeric protein-based composition is capable of specifically delivering payload to neural cells.
    Type: Application
    Filed: May 14, 2016
    Publication date: May 10, 2018
    Inventors: Benjamin J. Pavlik, Paul Blum, Kevin Van Cott
  • Micro-spike algae harvesting and biofuel extraction system and method therefor
    Patent number: 9243206
    Abstract: A micro-spike algae harvesting and biofuel extraction system and method therefor whereby an algal solution is dispersed from a selected height onto an inclined micro-spike board which forms a substrate for supporting an array of upwardly-extending miniature spikes, wherein the miniature spikes puncture algae cells suspended in the solution to release biofuel contained therein.
    Type: Grant
    Filed: January 28, 2015
    Date of Patent: January 26, 2016
    Inventors: John Kelson, Benjamin J. Pavlik
  • MICRO-SPIKE ALGAE HARVESTING AND BIOFUEL EXTRACTION SYSTEM AND METHOD THEREFOR
    Publication number: 20150141681
    Abstract: A micro-spike algae harvesting and biofuel extraction system and method therefor comprises dispersing an algal solution from a selected height onto an inclined micro-spike board forming a substrate for supporting an array of upwardly-extending miniature spikes, wherein the miniature spikes puncture algae cells suspended in the solution thereby releasing biofuel contained therein.
    Type: Application
    Filed: January 28, 2015
    Publication date: May 21, 2015
    Inventors: John Kelson, Benjamin J. Pavlik
  • Micro-spike algae harvesting and biofuel extraction system
    Patent number: 8960582
    Abstract: A micro-spike algae harvesting and biofuel extraction system including a micro-spike board supported at an inclined angle by a rigid framework and forming a planar substrate for support of an array of miniature, upwardly pointed, conically-shaped spikes, and a sprinkling system for dispersing an algal solution of algae cells from above the micro-spike board onto the array of spikes for puncturing the algae cells to release biofuel contained therein.
    Type: Grant
    Filed: April 27, 2012
    Date of Patent: February 24, 2015
    Inventors: John Kelson, Benjamin J. Pavlik
  • MICRO-SPIKE ALGAE HARVESTING AND BIOFUEL EXTRACTION SYSTEM
    Publication number: 20130115147
    Abstract: A micro-spike algae harvesting and biofuel extraction system comprises a micro-spike board supported at an inclined angle by a rigid framework and forming a planar substrate for support of an array of miniature, upwardly pointed, conically-shaped spikes, and a sprinkling system for dispersing an algal solution of algae cells from above the micro-spike board onto the array of spikes for puncturing the algae cells to release biofuel contained therein.
    Type: Application
    Filed: April 27, 2012
    Publication date: May 9, 2013
    Inventors: John Kelson, Benjamin J. Pavlik