Patents by Inventor Benjamin J. Tillotson

Benjamin J. Tillotson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • HIGH SALT WASHES DURING CATION EXCHANGE CHROMATOGRAPHY TO REMOVE PRODUCT-RELATED IMPURITIES
    Publication number: 20220372071
    Abstract: The invention relates to methods for removal of low isoelectric point product-related impurities during cation exchange purification operations.
    Type: Application
    Filed: November 4, 2020
    Publication date: November 24, 2022
    Applicant: AMGEN INC.
    Inventors: Malhar R. AMBHAIKAR, Luis DIAZ, Natalia R. GOMEZ, Benjamin J. TILLOTSON
  • A CONTINUOUS MANUFACTURING PROCESS FOR BIOLOGICS MANUFACTURING BY INTEGRATION OF DRUG SUBSTANCE AND DRUG PRODUCT PROCESSES
    Publication number: 20220119526
    Abstract: A biologics manufacturing process that connects the drug substance and drug product processes into an integrated, continuous process.
    Type: Application
    Filed: January 27, 2020
    Publication date: April 21, 2022
    Applicant: AMGEN INC.
    Inventors: Subramanian GUHAN, Malhar R. AMBHAIKAR, Vincent CHAI, Sai Chakradhar PADALA, Nitin RATHORE, Zane SAREMI, Kenneth SHOEMAKER, Benjamin J. TILLOTSON, Balakumar THANGARAJ, Philip CLARK, Ashish SHARMA, Hann-Chung WONG, John E. THORUP
  • pH-dependent antibodies targeting the transferrin receptor and methods of use thereof to deliver a therapeutic agent
    Patent number: 10233252
    Abstract: A pH-dependent antibody that binds an antigen with high affinity at a first pH and rapidly dissociates at a second pH, wherein the antigen is a transferrin receptor (TfR), wherein the association at the second pH/the first pH is less than 20%, and wherein the pH-dependent antibody comprises at least two consecutive histidine residues at a single complementarity determining region (CDR) is disclosed.
    Type: Grant
    Filed: December 15, 2016
    Date of Patent: March 19, 2019
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Eric V. Shusta, Benjamin J. Tillotson
  • pH Dependent Antibodies Targeting the Transferrin Receptor
    Publication number: 20170174778
    Abstract: A pH-dependent antibody that binds an antigen with high affinity at a first pH and rapidly dissociates at a second pH, wherein the antigen is a transferrin receptor (TfR), wherein the association at the second pH/the first pH is less than 20%, and wherein the pH-dependent antibody comprises at least two consecutive histidine residues at a single complementarity determining region (CDR) is disclosed.
    Type: Application
    Filed: December 15, 2016
    Publication date: June 22, 2017
    Inventors: Eric V. Shusta, Benjamin J. Tillotson