Abstract: Systems and methods for reusable molding devices in accordance with embodiments of the invention are disclosed. In one embodiment, a reusable molding device is provided comprising: an array comprising a plurality of pixel pins, which are arranged to form a two-dimensional plane and which are each linearly movable to create an impression of a surface of an object, a first pixel guide plate, a second pixel guide plate, a first clamp pressure plate, a second clamp pressure plate, a first clamp screw, wherein the first clamp screw moves the first clamp pressure plate towards the first side of the array, a second clamp screw which moves the second clamp pressure plate towards the second side of the array, a pressure clamp frame enclosing the first and second pixel guide plates and the first and second clamp pressure plates, and a top pressure plate, which includes an injection entrance bore.

Abstract: A microfluidic device (100) comprises: a reaction chamber (102); at least a first and a second supply channel (110a, 110b) for allowing transport of a first fluid and a second fluid, respectively, from a fluid supply source (112a, 112b) into the reaction chamber (102), wherein each of the first and the second supply channels (110a, 110b) comprises a side drain (114a, 114b) connected to the supply channel (110a, 110b) between the fluid supply source (112a, 112b) and the reaction chamber (102), wherein the side drain (114a, 114b) is configured to prevent undesired diffusion of the fluid in the supply channel (110a, 110b) into the reaction chamber (102); at least a first and a second outlet (120a, 120b) connected to the reaction chamber (102) for allowing transport of fluid from the reaction chamber (102), wherein the first and second outlets (120a, 120b) have different dimensions to provide different hydraulic resistance.

Abstract: The disclosure generally provides zeolites having the CHA crystalline framework and methods of preparing the same. Provided herein are CHA zeolites containing intergrowths, a controlled framework aluminum distribution, or both. Further provided are CHA zeolites wherein crystals of the zeolite material have a predominantly flake-like morphology as determined by scanning electron microscopy (SEM). Further provided are catalyst compositions, articles, and systems including CHA zeolites promoted with a metal.

Abstract: An electronic device situated in an electric vehicle displays the precise state of charge (SOC) and charging status of the vehicle such that this information is visible from a substantial distance outside the vehicle while the vehicle is charging, connected to a charging station, or idle after disconnection from a charging station. The displayed information is easily comprehensible to a driver in an approaching electric vehicle who is interested in using the charging station, allowing the approaching driver to quickly determine if the charging station is available for use, or how soon it may be available. A method for accessing and displaying information regarding an electric vehicle charging session, allowing for a constant display of charging information outside of the electric vehicle.

Abstract: Devices and methods for surface-induced association are disclosed herein. According to one embodiment, a device for surface-induced dissociation (SID) includes a collision surface and a deflector configured to guide precursor ions from a pre-SID region to the collision surface. In some embodiments, an extractor extracts ions off the collision surface after collision with the collision surface. In some embodiments, an RF device can collect and/or transmit the extracted ions. In some embodiments, an ion funnel guides product ions resulting from collision with the collision surface to a post-SID region. Some aspects of the disclosure are directed to methods for surface-induced dissociation, which may in some embodiments include using of a split lens or an ion funnel.

Abstract: A compound of Formula (I) is provided: where the variables are defined herein.

Abstract: A present inventive concept relates to a microfluidic arrangement comprising: a first section having a first plane and comprising a trigger channel and a stop channel, wherein the trigger channel and the stop channel are parallel with the first plane; wherein the trigger channel has a first portion having a first depth, and a second portion having a second, deeper, depth, the trigger channel being arranged to allow a liquid flow to the second portion from the first portion; and wherein the stop channel has an opening that fluidically connects the stop channel to the second portion of the trigger channel at a predetermined distance from a bottom of the trigger channel; the microfluidic arrangement further comprising: a second section having a second plane having a third portion comprising a plurality of elongated recesses, wherein the plurality of recesses are arranged separated from each other; wherein the first section and the second section are arranged with the first and the second planes in parallel, and

Abstract: The present embodiments provide compounds of Formula I, pharmaceutical compositions of the compounds, and methods for treating diseases such as cancer.

Abstract: The present invention provides a micro-reactor (1) adapted to host chemical reactions having at least one microfluidic layer, said micro-reactor (1) comprising a fluid inlet (2) and a fluid outlet (3); a plurality of micro-reaction chambers (10) arranged in rows (7) and columns (6), each micro-reaction chamber comprising a chamber inlet (10a) and a chamber outlet (10b); a plurality of supply channels (4) for supplying fluid to from said fluid inlet (2) to said micro-reaction chambers (10) and further arranged for draining said micro-reaction chambers (10) to said fluid outlet (3), said supply channels (10) extending in a first direction (D1) along the columns (6) of micro-reaction chambers (10) and arranged such that there is one supply channel (4) between adjacent columns (6).

Abstract: A tree stand and method of installing includes a rail system, a seat portion and a foot-rest portion. The seat portion and the rail portion are held to the rail portion by a climber mechanism that locks each to the rail upon downward pressure but allows each to be lifted to disengage with the rail for moving up/down the rail. By alternately locking/disengaging the climber mechanism with the rail, a user successively moves the foot-rest portion higher on the rail, then moves the seat portion higher on the rail until both are at a desired height.

Abstract: The disclosure generally provides zeolites having the CHA crystalline framework and methods of preparing the same. Provided herein are CHA zeolites containing intergrowths, a controlled framework aluminum distribution, or both. Further provided are CHA zeolites wherein crystals of the zeolite material have a predominantly flake-like morphology as determined by scanning electron microscopy (SEM). Further provided are catalyst compositions, articles, and systems including CHA zeolites promoted with a metal.

Abstract: A drive component is disclosed. The drive component may include a base of a first material having a first hardness and a plurality of wear inserts of a second material having a second hardness greater than the first hardness. The plurality of wear inserts may extend from an interior of the base to an exterior surface of the base. The base and the plurality of wear inserts may be a composite casting.

Abstract: Compounds with KRAS G12C inhibitory active are disclosed and methods of using the same to treat a cancer comprising a K-Ras G12C mutation.

Abstract: A track pad may include a base member and a roller path member extending from the base member. The roller path member may include a roller path surface for engaging with a roller of a machine. The roller path member may include a leading side and a trailing side in a direction of travel of the machine. The roller path member may include a hardened region that extends from the roller path surface and a body region adjacent the hardened region. The hardened region may have a greater hardness than the body region. The hardened region may have a uniform depth from the leading side to the trailing side of the roller path member.

Abstract: A system that determines that devices are co-located in an acoustic region and selects a single device to which to send incoming notifications for the acoustic region. The system may group devices into separate acoustic regions based on selection data that selects between similar audio data received from multiple devices. The system may select the best device for each acoustic region based on a frequency that the device was selected previously, input/output capabilities of the device, a proximity to a user, or the like. The system may send a notification to a single device in each of the acoustic regions so that a user receives a single notification instead of multiple unsynchronized notifications. The system may also determine that acoustic regions are associated with different locations and select acoustic regions to which to send a notification based on location.

Abstract: Disclosed are compounds of Formula 1, and pharmaceutically acceptable salts thereof, wherein G, L1, L2, R1, R2, R3, and R4 are defined in the specification. This disclosure also relates to materials and methods for preparing compounds of Formula 1, pharmaceutical compositions containing them, and their use for treating disorders, diseases, and conditions involving the immune system and inflammation, including rheumatoid arthritis, hematological malignancies, epithelial cancers (i.e., carcinomas), and other disorders, diseases, and conditions for which inhibition of SYK is indicated.

Abstract: A fluidic device (100) is described for locally coating an inner surface of a fluidic channel. The fluidic device (100) comprises a first (101), a second (102) and a third (103) fluidic channel intersecting at a common junction (105). The first fluidic channel is connectable to a coating fluid reservoir and the third fluidic channel is connectable to a sample fluid reservoir. The fluidic device (100) further comprises a fluid control means (111) configured for creating a fluidic flow path for a coating fluid at the common junction (105) such that, when coating, a coating fluid propagates from the first (101) to the second (102) fluidic channel via the common junction (105) without propagating into the third (103) fluidic channel. A corresponding method for coating and for sensing also has been disclosed.

Abstract: Disclosed herein are a control method and system. The system includes: a deactivation control; a control centre controller for storing an association between the deactivation control and a selected set of mine sites; a plurality of autonomous drill rigs, each drill rig having a drill shutdown module to disable a function of the respective drill rig upon receipt of a deactivation command; and a mine site controller associated with each mine site, each mine site controller being coupled to all autonomous drill rigs located at the respective mine site with which the mine site controller is associated. Activating the deactivation control transmits a deactivation command from the deactivation control to the control centre controller. The control centre controller forwards the deactivation command to a mine site controller associated with each mine site in the set of mine sites for distribution to all autonomous drill rigs at that mine site.

Abstract: Compounds with KRAS G12C inhibitory active are disclosed and methods of using the same to treat a cancer comprising a K-Ras G12C mutation.

Abstract: The disclosure relates to an arrangement (100) in a capillary driven fluid system for metering a predetermined volume of sample fluid. The arrangement comprises a sample reservoir (SR) arranged to receive a sample fluid, a first channel (C1) which is in fluid communication with the sample reservoir (SR) and which branches off into a second channel (C2) ending at a first valve (V1) and a third channel (C3) ending at a second valve (V2). The second channel (C2) and the third channel (C3) together have a predetermined volume, and the first channel (C1) is arranged to draw sample fluid from the sample reservoir (SR) by use of capillary forces to fill the second channel (C2) and the third channel (C3) with the predetermined volume of sample fluid. By selectively opening the first valve (V1) and the second valve (V2), a capillary driven flow may be formed, thereby causing the predetermined volume of sample fluid to flow out through the first valve (V1).