Abstract: The present invention relates to a microfluidic system (10, 20) comprising: a sample reservoir (110, 210); a first sample channel (120, 220) connected to the sample reservoir (110, 210), branching off into a second sample channel (122, 222) ending in a first valve (130, 230), and into a third sample channel (124, 224) which branches off into a fourth sample channel (126, 226) ending in a second valve (132, 232), and into a fifth sample channel (128, 228) ending in a third valve (134, 234); a buffer reservoir (140, 240); a first trigger channel (150, 250) arranged to connect the buffer reservoir (140, 240) to the second valve (132, 232); a second trigger channel (152, 252) connecting the second valve (132, 232) and the first valve (130, 230); and an exit channel (154, 254) connected to the first valve (130, 230).

Abstract: A collecting device (200) for collecting airborne particles comprises: a first (202) and second layer (220) spaced apart for forming a particle collection chamber (240; 340) therebetween: wherein inlets (210; 310) and outlets (230; 330) are configured for transporting a flow of air (104) into and out of the particle collection chamber (240; 340) and configured for allowing capturing airborne particles by impaction. The collecting device (200) further comprises at least one liquid access port (260; 260a, 260b; 360a-360h) for filling the particle collection chamber (240; 340) with a reagent; and wherein the particle collection chamber (240; 340) comprises at least one side wall (246; 346) for defining flow of the reagent, such that a first portion (248a; 348a) and a second portion (248b; 348b) of the particle collection chamber (240; 340) are arranged on opposite sides of the at least one side wall (246; 346).

Abstract: The disclosure relates, in particular, to the operation of radio frequency (RF) ion guides which receive, intermediately store, separate according to a physical-chemical property, spatially translate and finally output gas-phase ions. RF ion guides according to the disclosure may be part of, or be coupled with, a mass analyzer. The disclosure serves to improve the space charge capacity of an RF ion guide, and to minimize fragmentation losses of ions contained in such RF ion guide over a wide range of masses and/or mobilities. The disclosure further serves to optimize the operational characteristics of an RF ion guide over a wide range of physical-chemical property values at minimal loss of ions due to fragmentation by RF ion heating.

Abstract: The present disclosure relates to a micropump device for creating a net fluid flow along a flow direction. The device includes a fluid channel and a plurality of piezoelectric transducers arranged adjacent to the fluid channel. The piezoelectric transducers are organized into a set of at least three groups. The groups are consecutively arranged along the flow direction, and each group includes at least one piezoelectric transducer. A controller of the device is configured to actuate the piezoelectric transducers using at least three periodic electrical control signals. Each electrical control signal is associated with one group of the set. The controller is configured to consecutively delay the at least three electrical control signals, in accordance with the consecutively arranged groups of the set, to create the net flow of fluid along the flow direction.

Abstract: Disclosed herein are a control method and system. The system includes: a deactivation control; a control centre controller for storing an association between the deactivation control and a selected set of mine sites; a plurality of autonomous drill rigs, each drill rig having a drill shutdown module to disable a function of the respective drill rig upon receipt of a deactivation command; and a mine site controller associated with each mine site, each mine site controller being coupled to all autonomous drill rigs located at the respective mine site with which the mine site controller is associated. Activating the deactivation control transmits a deactivation command from the deactivation control to the control centre controller. The control centre controller forwards the deactivation command to a mine site controller associated with each mine site in the set of mine sites for distribution to all autonomous drill rigs at that mine site.

Abstract: A method for fabricating a microfluidic device includes providing an assembly that includes a first silicon substrate having a hydrophilic silicon oxide top surface that includes a microfluidic channel and a second silicon substrate having a hydrophilic silicon oxide bottom surface directly bonded on the top surface of the first silicon substrate, the second silicon substrate including fluidic access holes giving fluidic access to the microfluidic channel. The method also includes exposing the assembly to oxidative species including one or more oxygen atoms and to heat so as to form silicon oxide at a surface of the access holes and of the microfluidic channel.

Abstract: Disclosed herein are a control method and system. The system includes: a deactivation control; a control centre controller for storing an association between the deactivation control and a selected set of mine sites; a plurality of autonomous drill rigs, each drill rig having a drill shutdown module to disable a function of the respective drill rig upon receipt of a deactivation command; and a mine site controller associated with each mine site, each mine site controller being coupled to all autonomous drill rigs located at the respective mine site with which the mine site controller is associated. Activating the deactivation control transmits a deactivation command from the deactivation control to the control centre controller. The control centre controller forwards the deactivation command to a mine site controller associated with each mine site in the set of mine sites for distribution to all autonomous drill rigs at that mine site.

Abstract: A flow control system for a microfluidic device includes: a plurality of fluid flow controllers, each fluid flow controller associated with a respective microfluidic device inlet of the microfluidic device, and wherein each fluid flow controller includes: a controller inlet for receiving a fluid flow, a first fluid channel and a second fluid channel, each of the first and the second fluid channels having a first end connected to the controller inlet and a second end connected to a supply channel, and a valve for selecting the fluid flow to be passed from the controller inlet to the first fluid channel or to the second fluid channel, wherein the first fluid channel has a first flow resistance that smaller than a second flow resistance of the second fluid channel.

Abstract: An apparatus for an ion spectrometric system facilitates the transmission of ions and comprises a concave ion deflector, having a plurality of conducting electrodes following an inward curved surface. The apparatus also includes a pusher that deflects ions, an RF voltage supply that applies an RF voltage to the concave ion deflector and an output configured to emanate a directed gas flow comprising ions toward the inward curved surface of the concave ion deflector. The output is located outside the concave ion deflector and the concave ion deflector is configured to retain and deflect ions coming from the output while simultaneously allowing other particles coming from the output to pass through the plurality of conducting electrodes. The present invention also relates to a method for facilitating the transmission of ions in an ion spectrometric system.

Abstract: A microfluidic device (100) comprises: a reaction chamber (102); at least a first and a second supply channel (110a, 110b) for allowing transport of a first fluid and a second fluid, respectively, from a fluid supply source (112a, 112b) into the reaction chamber (102), wherein each of the first and the second supply channels (110a, 110b) comprises a side drain (114a, 114b) connected to the supply channel (110a, 110b) between the fluid supply source (112a, 112b) and the reaction chamber (102), wherein the side drain (114a, 114b) is configured to prevent undesired diffusion of the fluid in the supply channel (110a, 110b) into the reaction chamber (102); at least a first and a second outlet (120a, 120b) connected to the reaction chamber (102) for allowing transport of fluid from the reaction chamber (102), wherein the first and second outlets (120a, 120b) have different dimensions to provide different hydraulic resistance.

Abstract: An electronic device situated in an electric vehicle displays the precise state of charge (SOC) and charging status of the vehicle such that this information is visible from a substantial distance outside the vehicle while the vehicle is charging, connected to a charging station, or idle after disconnection from a charging station. The displayed information is easily comprehensible to a driver in an approaching electric vehicle who is interested in using the charging station, allowing the approaching driver to quickly determine if the charging station is available for use, or how soon it may be available. A method for accessing and displaying information regarding an electric vehicle charging session, allowing for a constant display of charging information outside of the electric vehicle.

Abstract: Devices and methods for surface-induced association are disclosed herein. According to one embodiment, a device for surface-induced dissociation (SID) includes a collision surface and a deflector configured to guide precursor ions from a pre-SID region to the collision surface. In some embodiments, an extractor extracts ions off the collision surface after collision with the collision surface. In some embodiments, an RF device can collect and/or transmit the extracted ions. In some embodiments, an ion funnel guides product ions resulting from collision with the collision surface to a post-SID region. Some aspects of the disclosure are directed to methods for surface-induced dissociation, which may in some embodiments include using of a split lens or an ion funnel.

Abstract: A compound of Formula (I) is provided: where the variables are defined herein.

Abstract: The present embodiments provide compounds of Formula I, pharmaceutical compositions of the compounds, and methods for treating diseases such as cancer.

Abstract: A present inventive concept relates to a microfluidic arrangement comprising: a first section having a first plane and comprising a trigger channel and a stop channel, wherein the trigger channel and the stop channel are parallel with the first plane; wherein the trigger channel has a first portion having a first depth, and a second portion having a second, deeper, depth, the trigger channel being arranged to allow a liquid flow to the second portion from the first portion; and wherein the stop channel has an opening that fluidically connects the stop channel to the second portion of the trigger channel at a predetermined distance from a bottom of the trigger channel; the microfluidic arrangement further comprising: a second section having a second plane having a third portion comprising a plurality of elongated recesses, wherein the plurality of recesses are arranged separated from each other; wherein the first section and the second section are arranged with the first and the second planes in parallel, and

Abstract: The present invention provides a micro-reactor (1) adapted to host chemical reactions having at least one microfluidic layer, said micro-reactor (1) comprising a fluid inlet (2) and a fluid outlet (3); a plurality of micro-reaction chambers (10) arranged in rows (7) and columns (6), each micro-reaction chamber comprising a chamber inlet (10a) and a chamber outlet (10b); a plurality of supply channels (4) for supplying fluid to from said fluid inlet (2) to said micro-reaction chambers (10) and further arranged for draining said micro-reaction chambers (10) to said fluid outlet (3), said supply channels (10) extending in a first direction (D1) along the columns (6) of micro-reaction chambers (10) and arranged such that there is one supply channel (4) between adjacent columns (6).

Abstract: A tree stand and method of installing includes a rail system, a seat portion and a foot-rest portion. The seat portion and the rail portion are held to the rail portion by a climber mechanism that locks each to the rail upon downward pressure but allows each to be lifted to disengage with the rail for moving up/down the rail. By alternately locking/disengaging the climber mechanism with the rail, a user successively moves the foot-rest portion higher on the rail, then moves the seat portion higher on the rail until both are at a desired height.

Abstract: A collecting device (200) for collecting airborne particles comprises: a first (202) and second layer (220) spaced apart for forming a particle collection chamber (240; 340) therebetween: wherein inlets (210; 310) and outlets (230; 330) are configured for transporting a flow of air (104) into and out of the particle collection chamber (240; 340) and configured for allowing capturing airborne particles by impaction. The collecting device (200) further comprises at least one liquid access port (260; 260a, 260b; 360a-360h) for filling the particle collection chamber (240; 340) with a reagent; and wherein the particle collection chamber (240; 340) comprises at least one side wall (246; 346) for defining flow of the reagent, such that a first portion (248a; 348a) and a second portion (248b; 348b) of the particle collection chamber (240; 340) are arranged on opposite sides of the at least one side wall (246; 346).

Abstract: A drive component is disclosed. The drive component may include a base of a first material having a first hardness and a plurality of wear inserts of a second material having a second hardness greater than the first hardness. The plurality of wear inserts may extend from an interior of the base to an exterior surface of the base. The base and the plurality of wear inserts may be a composite casting.

Abstract: Compounds with KRAS G12C inhibitory active are disclosed and methods of using the same to treat a cancer comprising a K-Ras G12C mutation.