Patents by Inventor Benjamin L. Barthel

Benjamin L. Barthel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Anthracycline prodrugs and methods of making and using the same
    Patent number: 10912767
    Abstract: The present invention includes compounds of the class anthracycline that have been modified to include photo-activated prodrug anthracycline compounds that are useful in the treatment of cancer. One example composition of the invention may include photodoxazolidine which may be synthesized in two steps from 4,5-dimethoxy-2-nitrobenzyl alcohol and doxazolidine. In this embodiment commercial 4,5-dimethoxyl-2-nitrobenzyl alcohol reacts with p-nitrophenylchloroformate to give the p-nitrophenyl carbonate of the benzyl alcohol derivative. The p-nitrophenyl carbonate is then reacted with doxazolidine to give the exemplary photodoxazolidine composition.
    Type: Grant
    Filed: April 27, 2016
    Date of Patent: February 9, 2021
    Assignee: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE
    Inventors: Tad H. Koch, Benjamin L. Barthel, Hang Hubert Yin, Ryo Tamura, Alla Balabanova
  • ANTHRACYCLINE PRODRUGS AND METHODS OF MAKING AND USING THE SAME
    Publication number: 20180110756
    Abstract: Therapeutically effective prodrug compounds for the prevention and treatment of cancer and pharmaceutical compositions containing these compounds as well as methods of making and using these compounds.
    Type: Application
    Filed: April 27, 2016
    Publication date: April 26, 2018
    Inventors: Tad H. KOCH, Benjamin L. BARTHEL, Hang Hubert YIN, Ryo TAMURA, Alla BALABANOVA
  • Methods of treating cancer with doxazolidine and prodrugs thereof
    Patent number: 8404650
    Abstract: The invention provides therapeutically effective compounds for the prevention and treatment of cancer and pharmaceutical compositions containing these compounds as well as methods of using and administering these compounds. The invention also includes methods of activating a prodrug of these therapeutically effective compounds by the administration of a peptide-directed targeting construct that delivers a prodrug-activating enzyme to a target activation site.
    Type: Grant
    Filed: October 30, 2006
    Date of Patent: March 26, 2013
    Assignee: The Regents of the University of Colorado, a body corporate
    Inventors: Tad H. Koch, David J. Burkhart, Glen C. Post, Jordan W. Nafie, Brian T. Kalet, Benjamin L. Barthel, Daniel L. Rudnicki
  • METHODS OF TREATING CANCER WITH DOXAZOLIDINE AND PRODRUGS THEREOF
    Publication number: 20110135618
    Abstract: The invention provides therapeutically effective compounds for the prevention and treatment of cancer and pharmaceutical compositions containing these compounds as well as methods of using and administering these compounds. The invention also includes methods of activating a prodrug of these therapeutically effective compounds by the administration of a peptide-directed targeting construct that delivers a prodrug-activating enzyme to a target activation site.
    Type: Application
    Filed: October 30, 2006
    Publication date: June 9, 2011
    Applicant: THE REGENTS OF THE UNIVERSITY OF COLORADO
    Inventors: Tad H. Koch, David J. Burkhart, Glen C. Post, Jordan W. Nafie, Brian T. Kalet, Benjamin L. Barthel, Daniel L. Rudnicki