Patents by Inventor Benjamin L. PROSSER

Benjamin L. PROSSER has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20230140435
    Abstract: A recombinant viral vector comprising an expression cassette which comprises a coding sequence for an shRNA inhibitor of vasohibin (VASH)-small vasohibin binding protein (SVBP) complex operably linked to regulatory sequences which direct expression thereof is provided. Further provided are compositions containing such viral vectors formulated for delivery to a human patient. Also provided are methods using these vectors and compositions for improving or stabilizing cardiac function.
    Type: Application
    Filed: March 16, 2021
    Publication date: May 4, 2023
    Inventors: Benjamin L. Prosser, Kenneth B. Margulies, Alexey Bogush
  • Publication number: 20220228146
    Abstract: Disclosed herein are compounds and methods for modulating expression of disease-causing genes such as STXBP1, SCN1A, SCN2A, SCN8A, SLC6A1, and MECP2. Such compounds and methods are useful to treat, prevent, or ameliorate epileptic encephalopathy and neurodevelopmental disorders in an individual in need thereof.
    Type: Application
    Filed: May 6, 2020
    Publication date: July 21, 2022
    Applicants: THE CHILDREN'S HOSPITAL OF PHILADELPHIA, THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: Beverly DAVIDSON, Benjamin L. PROSSER, Ingo HELBIG
  • Publication number: 20180326022
    Abstract: Described herein is a method for improving or stabilizing cardiac function by inhibiting tubulin carboxypeptidase (TCP). Also described herein is a method for treating heart failure in humans comprising dosing a patient with a therapeutic which interferes with detyrosinated microtubules in cardiomyocytes. Also provided are viral vectors which comprise a nucleic acid encoding a tubulin tyrosine ligase (TTL) gene under the control of regulatory elements direct expression thereof. Compositions are also provided which contain such viral vectors formulated for delivery to a human patient.
    Type: Application
    Filed: April 21, 2018
    Publication date: November 15, 2018
    Inventors: Benjamin L. Prosser, Kenneth B. Margulies
  • Patent number: 8921066
    Abstract: Bio-adhesive compositions that include an extra-cellular matrix protein, bovine serum albumin conjugated with a fluorophore, and an aggregate are provided. The bio-adhesive composition may also include at least one component selected from the group consisting of collagen type IV, laminin, and chitosan. Also provided are methods of making the present compositions, that include taking a desired amount of extracellular matrix gel to liquid form of extracellular matrix; adding a desired amount of bovine serum albumin conjugated with a fluorophore; adding a desired amount of aggregate; and mixing. Further provided are methods for attaching cells to an apparatus using the present bio-adhesive compositions, and methods of attaching the present bio-adhesive compositions to an apparatus. Also provided are kits that include the present composition, components thereof or apparatuses, having the present composition attached thereto.
    Type: Grant
    Filed: August 3, 2011
    Date of Patent: December 30, 2014
    Assignee: University of Maryland, Baltimore
    Inventors: Christopher Ward, William J. Lederer, Benjamin L. Prosser
  • Publication number: 20120034620
    Abstract: Bio-adhesive compositions that include an extra-cellular matrix protein, bovine serum albumin conjugated with a fluorophore, and an aggregate are provided. The bio-adhesive composition may also include at least one component selected from the group consisting of collagen type IV, laminin, and chitosan. Also provided are methods of making the present compositions, that include taking a desired amount of extracellular matrix gel to liquid form of extracellular matrix; adding a desired amount of bovine serum albumin conjugated with a fluorophore; adding a desired amount of aggregate; and mixing. Further provided are methods for attaching cells to an apparatus using the present bio-adhesive compositions, and methods of attaching the present bio-adhesive compositions to an apparatus. Also provided are kits that include the present composition, components thereof or apparatuses, having the present composition attached thereto.
    Type: Application
    Filed: August 3, 2011
    Publication date: February 9, 2012
    Applicant: UNIVERSITY OF MARYLAND, BALTIMORE
    Inventors: Christopher WARD, William J. LEDERER, Benjamin L. PROSSER