Patents by Inventor Benjamin L. Viglianti

Benjamin L. Viglianti has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Halogenated Cholesterol Analogues and Methods of Making and Using Same
    Publication number: 20210355154
    Abstract: Provided herein are halogenated cholesterol analogues, including methods of making and using the same. Also provided are methods of making radiolabeled cholesterol analogues including admixing an epoxide with a fluorine-18 source under conditions to form a radiofluorinated cholesterol analogue.
    Type: Application
    Filed: September 27, 2019
    Publication date: November 18, 2021
    Inventors: Benjamin L. Viglianti, Allen F. Brooks, Peter J. H. Scott, Stephen Thompson, Stefan Verhoog, Milton D. Gross, Wade P. Winton
  • MRI imageable liposomes for the evaluation of treatment efficacy, thermal distribution, and demonstration of dose painting
    Patent number: 7769423
    Abstract: Methods and compositions useful for detecting an in vivo blood pool, monitoring the distribution of a compound of interest to a desired site in an organism by magnetic resonance imaging, monitoring the accumulation of a compound of interest at a desired site in vivo by magnetic resonance imaging, and monitoring the release of liposomal contents to an external stimulus at a desired site in vivo by magnetic resonance imaging are disclosed. Some compositions comprise envirosensitive or non-sensitive liposomes. Contrast agents, such as manganese-based compounds, are also disclosed.
    Type: Grant
    Filed: December 29, 2006
    Date of Patent: August 3, 2010
    Assignee: Duke University
    Inventors: Benjamin L. Viglianti, Mark W. Dewhirst, Ana M. Ponce
  • Methods and compositions for blood pool identification, drug distribution quantification and drug release verification
    Patent number: 7672704
    Abstract: Methods and compositions useful for detecting an in vivo blood pool, monitoring the distribution of a compound of interest to a desired site in an organism by magnetic resonance imaging, monitoring the accumulation of a compound of interest at a desired site in vivo by magnetic resonance imaging, and monitoring the release of liposomal contents to an external stimulus at a desired site in vivo by magnetic resonance imaging are disclosed. Some compositions comprise envirosensitive or non-sensitive liposomes. Contrast agents, such as manganese-based compounds, are also disclosed.
    Type: Grant
    Filed: September 11, 2003
    Date of Patent: March 2, 2010
    Assignee: Duke University
    Inventors: Benjamin L. Viglianti, Mark W. Dewhirst, James R. MacFall, Zeljko Vujaskovic
  • Methods and compositions for blood pool identification, drug distribution quantification and drug release verification
    Publication number: 20040101969
    Abstract: Methods and compositions useful for detecting an in vivo blood pool, monitoring the distribution of a compound of interest to a desired site in an organism by magnetic resonance imaging, monitoring the accumulation of a compound of interest at a desired site in vivo by magnetic resonance imaging, and monitoring the release of liposomal contents to an external stimulus at a desired site in vivo by magnetic resonance imaging are disclosed. Some compositions comprise envirosensitive or non-sensitive liposomes. Contrast agents, such as manganese-based compounds, are also disclosed.
    Type: Application
    Filed: September 11, 2003
    Publication date: May 27, 2004
    Applicant: Duke University
    Inventors: Benjamin L. Viglianti, Mark W. Dewhirst, James R. MacFall, Zeljko Vujaskovic