Abstract: A method of forming a ceramic matrix composite (CMC) component having an engineered surface includes applying a surface slurry comprising first particulate solids in a liquid carrier to an outer surface of a ceramic fiber preform. The surface slurry is dried to remove the liquid carrier, and thus a surface slurry layer comprising the first particulate solids is formed on the outer surface. The surface slurry layer is polished to a predetermined thickness and/or surface finish. After polishing, a ceramic tape comprising second particulate solids is applied to the surface slurry layer, and pressure is applied to attach the ceramic tape to the surface slurry layer and to induce consolidation of the ceramic tape and the surface slurry layer. Thus, a multilayer surface region comprising the surface slurry layer and a ceramic tape layer is formed on the ceramic fiber preform.

Abstract: A coffee making appliance includes a housing having a base for supporting a container configured to receive brewed coffee and a reservoir for receiving water to be heated. A hopper is configured to receive a quantity of whole coffee beans and is positioned adjacent a grinder that is itself configured to transform the whole coffee beans into ground coffee. A passageway is formed in the housing for channeling the ground coffee from the grinder to a brewing chamber. A pump configured to supply the water from said reservoir to said brewing chamber via a brew path and the brew path then directs said heated water over the passageway, thereby cleaning the passageway of particulates of the ground coffee.

Abstract: The invention relates to a linear polyglycerol compound, comprising a backbone of linearly linked glycerol residues. This compound is characterized in that it carries a plurality of substituents in the nature of covalently bound sulfates, wherein a degree of substitution of the backbone is preferably between 30 and 100%. A method of manufacturing the compound as well as uses of this compound and similar compounds are also disclosed.

Abstract: A method of forming a ceramic matrix composite (CMC) component having an engineered surface includes applying a surface slurry comprising first particulate solids in a liquid carrier to an outer surface of a ceramic fiber preform. The surface slurry is dried to remove the liquid carrier, and thus a surface slurry layer comprising the first particulate solids is formed on the outer surface. The surface slurry layer is polished to a predetermined thickness and/or surface finish. After polishing, a ceramic tape comprising second particulate solids is applied to the surface slurry layer, and pressure is applied to attach the ceramic tape to the surface slurry layer and to induce consolidation of the ceramic tape and the surface slurry layer. Thus, a multilayer surface region comprising the surface slurry layer and a ceramic tape layer is formed on the ceramic fiber preform.

Abstract: Techniques for onboarding users to various product features are described. According to various embodiments, information identifying a set of candidate onboarding content items associated with an email type of an email to be transmitted to a particular member of an online social network service is accessed. Thereafter, a first subset of the candidate onboarding content items is removed from the set, responsive to determining that the particular member has already been onboarded to products associated with the candidate onboarding content items in the first subset. Further, a second subset of the candidate onboarding content items is removed from the set, responsive to determining that the particular member has previously viewed and not interacted with the candidate onboarding content items in the second subset. A specific onboarding content item is then dynamically selected from the remaining set of candidate onboarding content items.

Abstract: A coffee making appliance includes a housing having a base for supporting a container configured to receive brewed coffee and a reservoir for receiving water to be heated. A hopper is configured to receive a quantity of whole coffee beans and is positioned adjacent a grinder that is itself configured to transform the whole coffee beans into ground coffee. A passageway is formed in the housing for channeling the ground coffee from the grinder to a brewing chamber. A pump configured to supply the water from said reservoir to said brewing chamber via a brew path and the brew path then directs said heated water over the passageway, thereby cleaning the passageway of particulates of the ground coffee.

Abstract: Techniques for onboarding users to online product features are described. According to various embodiments, email content data describing an email type of an email to be transmitted to a particular member is accessed. Information identifying a plurality of candidate onboarding content items associated with the email type is also accessed. Feature data including member onboarding content item interaction data describing the particular member's interactions with various onboarding content items is also accessed. Thereafter, for the particular member and the email type, a relevance score is generated for each of the candidate onboarding content items, based on the email content data and the member onboarding content item interaction data. Each of the relevance scores may indicate a likelihood that the particular member selects the corresponding candidate onboarding content item.

Abstract: A coffee making appliance includes a housing having a base for supporting a container configured to receive brewed coffee, a reservoir for receiving water to be heated, a hopper configured to receive a quantity of whole coffee beans, the hopper having an outlet, a vertically-oriented burr grinder positioned adjacent to the outlet of said hopper, the grinder being configured to transform the whole coffee beans into coffee grounds, a filter removably received by the housing for receiving the coffee grounds from the grinder, a pump configured to supply water from the reservoir to the filter, and a driving mechanism configured to rotate the filter while the water is supplied to the filter to cause the water to pass radially through the coffee grounds to produce the brewed coffee.

Abstract: The invention relates to a linear polyglycerol compound, comprising a backbone of linearly linked glycerol residues. This compound is characterized in that it carries a plurality of substituents in the nature of covalently bound sulfates, wherein a degree of substitution of the backbone is preferably between 30 and 100%. A method of manufacturing the compound as well as uses of this compound and similar compounds are also disclosed.

Abstract: A coffee making appliance includes a housing having a base for supporting a container configured to receive brewed coffee, a reservoir for receiving water to be heated, a hopper configured to receive a quantity of whole coffee beans, the hopper having an outlet, a vertically-oriented burr grinder positioned adjacent to the outlet of said hopper, the grinder being configured to transform the whole coffee beans into coffee grounds, a filter removably received by the housing for receiving the coffee grounds from the grinder, a pump configured to supply water from the reservoir to the filter, and a driving mechanism configured to rotate the filter while the water is supplied to the filter to cause the water to pass radially through the coffee grounds to produce the brewed coffee.

Abstract: Techniques for onboarding users to online product features are described. According to various embodiments, email content data describing an email type of an email to be transmitted to a particular member is accessed. Information identifying a plurality of candidate onboarding content items associated with the email type is also accessed. Feature data including member onboarding content item interaction data describing the particular member's interactions with various onboarding content items is also accessed. Thereafter, for the particular member and the email type, a relevance score is generated for each of the candidate onboarding content items, based on the email content data and the member onboarding content item interaction data. Each of the relevance scores may indicate a likelihood that the particular member selects the corresponding candidate onboarding content item.

Abstract: Techniques for onboarding users to various product features are described. According to various embodiments, information identifying a set of candidate onboarding content items associated with an email type of an email to be transmitted to a particular member of an online social network service is accessed. Thereafter, a first subset of the candidate onboarding content items is removed from the set, responsive to determining that the particular member has already been onboarded to products associated with the candidate onboarding content items in the first subset. Further, a second subset of the candidate onboarding content items is removed from the set, responsive to determining that the particular member has previously viewed and not interacted with the candidate onboard* content items in the second subset. A specific onboarding content item is then dynamically selected from the remaining set of candidate onboarding content items.

Abstract: Apparatus and Methods are provided for a microfabricated fluorescence activated cell sorter based on a switch for rapid, active control of cell routing through a microfluidic channel network. This sorter enables low-stress, highly efficient sorting of populations of small numbers of cells (i.e., 1000-100,000 cells). The invention includes packaging of the microfluidic channel network in a self-contained plastic cartridge that enables microfluidic channel network to macro-scale instrument interconnect, in a sterile, disposable format. Optical and/or fluidic switching forces are used alone or in combination to effect switching.

Abstract: Systems, apparatus and methods are provided for biochemical analysis of a sample (e.g., a cell or nucleic acids). Samples are analyzed for molecular information and remain accessible for subsequent analysis or testing. The systems, apparatus and methods and systems provided are useful for performing quantitative and highly parallel biochemical reactions on biological samples in a high-throughput manner.

Abstract: Apparatus and Methods are provided for a microfabricated fluorescence activated cell sorter based on a switch for rapid, active control of cell routing through a microfluidic channel network. This sorter enables low-stress, highly efficient sorting of populations of small numbers of cells (i.e., 1000-100,000 cells). The invention includes packaging of the microfluidic channel network in a self-contained plastic cartridge that enables microfluidic channel network to macro-scale instrument interconnect, in a sterile, disposable format. Optical and/or fluidic switching forces are used alone or in combination to effect switching.

Abstract: Apparatus and Methods are provided for a microfabricated fluorescence activated cell sorter based on a switch for rapid, active control of cell routing through a microfluidic channel network. This sorter enables low-stress, highly efficient sorting of populations of small numbers of cells (i.e., 1000-100,000 cells). The invention includes packaging of the microfluidic channel network in a self-contained plastic cartridge that enables microfluidic channel network to macro-scale instrument interconnect, in a sterile, disposable format. Optical and/or fluidic switching forces are used alone or in combination to effect switching.

Abstract: In one embodiment, a method of assigning transcripts to probe sets is described that comprises retrieving one or more data sets from one or more sources; generating one or more clusters using transcript data from the data sets; aligning one or more probe sequences to a representative sequence from one or more of the clusters; aligning the representative sequence to a genome sequence, wherein the genome sequence is annotated with probe location information; mapping the aligned probe sequences to the genome sequence using the alignment of the representative sequence and genome sequence; and computing a score using a number associated with the aligned probe sequences and a number associated with the probe location formation associated with a region of the genome sequence that corresponds to the aligned representative sequence.