Abstract: The present disclosure relates generally to the field of cancer immunotherapy. More particularly, the present disclosure provides antibody recruitment molecules, pharmaceutical compositions comprising same and kits comprising same. The present disclosure also provides methods of treating cancer using the antibody recruitment molecules in combination with oncolytic virus therapy, and methods for enhancing the efficacy and/or reducing the toxicity of the oncolytic virus therapy.

Abstract: The present application relates to compounds of Formula I comprising an antibody binding domain (ABD) comprising a hapten that binds to an antibody in a subject, the antibody comprising a hapten binding site, an antibody labelling domain (ALD) comprising a functional group that forms a covalent bond with an amino acid in the antibody that is proximal to the hapten binding site and the formation of the covalent bond results in elimination of the ABD and either a target binding domain (TBD) or a detection moiety domain (DMD), each domain being optionally connected with independently selected linkers. The present application also includes methods and uses of the compounds, for example, for immune recognition of target cells by recruited labelled antibodies.

Abstract: The present application relates to compounds of Formula I comprising an antibody binding domain (ABD) comprising a hapten that binds to an antibody in a subject, the antibody comprising a hapten binding site, an antibody labelling domain (ALD) comprising a functional group that forms a covalent bond with an amino acid in the antibody that is proximal to the hapten binding site and the formation of the covalent bond results in elimination of the ABD and either a target binding domain (TBD) or a detection moiety domain (DMD), each domain being optionally connected with independently selected linkers. The present application also includes methods and uses of the compounds, for example, for immune recognition of target cells by recruited labelled antibodies.

Abstract: The present application relates to compounds of Formula I comprising an antibody binding domain (ABD) comprising a hapten that binds to an antibody in a subject, the antibody comprising a hapten binding site, an antibody labelling domain (ALD) comprising a functional group that forms a covalent bond with an amino acid in the antibody that is proximal to the hapten binding site and the formation of the covalent bond results in elimination of the ABD and either a target binding domain (TBD) or a detection moiety domain (DMD), each domain being optionally connected with independently selected linkers. The present application also includes methods and uses of the compounds, for example, for immune recognition of target cells by recruited labelled antibodies.

Abstract: A method of manufacturing a safety valve chamber housing can include depositing a chamber housing material, and thereby gradually building up the chamber housing and forming a chamber in the chamber housing enclosed by the chamber housing material, the chamber being bounded by only a single solid structure of the chamber housing. A safety valve can include a piston, and a chamber housing having a piston bore and a chamber formed therein, the piston bore being in communication with the chamber, the chamber being enclosed by only a single chamber housing material. A well system can include a safety valve connected in a tubular string, the safety valve including a chamber housing with a chamber in communication with a control line, inner and outer walls of the chamber housing being made of a continuous chamber housing material.

Abstract: A method of manufacturing a safety valve chamber housing can include depositing a chamber housing material, and thereby gradually building up the chamber housing and forming a chamber in the chamber housing enclosed by the chamber housing material, the chamber being bounded by only a single solid structure of the chamber housing. A safety valve can include a piston, and a chamber housing having a piston bore and a chamber formed therein, the piston bore being in communication with the chamber, the chamber being enclosed by only a single chamber housing material. A well system can include a safety valve connected in a tubular string, the safety valve including a chamber housing with a chamber in communication with a control line, inner and outer walls of the chamber housing being made of a continuous chamber housing material.

Abstract: A method of manufacturing a safety valve chamber housing can include depositing a chamber housing material, and thereby gradually building up the chamber housing and forming a chamber in the chamber housing enclosed by the chamber housing material, the chamber being bounded by only a single solid structure of the chamber housing. A safety valve can include a piston, and a chamber housing having a piston bore and a chamber formed therein, the piston bore being in communication with the chamber, the chamber being enclosed by only a single chamber housing material. A well system can include a safety valve connected in a tubular string, the safety valve including a chamber housing with a chamber in communication with a control line, inner and outer walls of the chamber housing being made of a continuous chamber housing material.

Abstract: Embodiments of the invention generally relate to a failsafe subsurface controlled safety valve. In one embodiment, a failsafe subsurface controlled safety valve assembly includes: a tubular housing; a closure member disposed in the tubular housing, wherein the closure member is movable between a closed position and an open position; an operating piston operable to move the closure member between the closed position and the open position; and a trigger piston operable to move the closure member from the open position to the closed position.

Abstract: Embodiments of the invention generally relate to a failsafe subsurface controlled safety valve. In one embodiment, a failsafe subsurface controlled safety valve assembly includes: a tubular housing; a closure member disposed in the tubular housing, wherein the closure member is movable between a closed position and an open position; an operating piston operable to move the closure member between the closed position and the open position; and a trigger piston operable to move the closure member from the open position to the closed position.