Abstract: The present invention features compositions and methods for identifying a subject having a B cell neoplasia or related condition responsive to treatment with lenalidomide and lenalidoinide-related compounds.

Abstract: A system and process for inter alia coating a substrate such as glass substrate with a layer of aluminum oxide to create a scratch-resistant and shatter-resistant matrix comprised of a thin scratch-resistant aluminum oxide film deposited on one or more sides of a transparent and shatter-resistant substrate for use in consumer and mobile devices such as watch crystals, cell phones, tablet computers, personal computers and the like. The system and process may include a sputtering technique. The system and process may produce a thin window that has a thickness of about 2 mm or less, and the matrix (i.e., the combination of the aluminum oxide film and transparent substrate) may have a shatter resistance with a Young's Modulus value that is less than that of sapphire, i.e., less than about 350 gigapascals (GPa). The thin window has superior shatter-resistant characteristics.

Abstract: The invention provides for delivery, engineering and optimization of systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are delivery systems and tissues or organ which are targeted as sites for delivery. Also provided are vectors and vector systems some of which encode one or more components of a CRISPR complex, as well as methods for the design and use of such vectors. Also provided are methods of directing CRISPR complex formation in eukaryotic cells to enable genome engineering in an organism to recapitulate the genetic complexity of disease or a condition and further interrogate gene function.

Abstract: Somatic non-silent mutations on selected biomarkers are reliable indicators for the overall survival of Myelodysplastic Syndrome subjects.

Abstract: A method for determining prognosis in a subject having a hematological cancer comprising: a) determining an expression profile by measuring the gene expression levels of a set of genes selected from a leukemic stem cell (LSC) gene signature marker set or an hematopoietic stem cell (HSC) gene signature marker set, in a sample from a subject; and b) classifying the subject as having a good prognosis or a poor prognosis based on the expression profile; wherein a good prognosis predicts an increased likelihood of survival within a predetermined period after initial diagnosis and poor prognosis predicts a decreased likelihood of survival within the predetermined period after initial diagnosis.

Abstract: A method and apparatus for storing and using “register use” information to determine when a register is being used for the last time so that power savings may be achieved is disclosed. The register use information may take the form of “last read” information for a particular register. The last read information may be used to force the value of the register, after being read, to zero or to clock only that register while masking off the other registers. Several methods and hardware variations are disclosed for using the register use information to achieve power savings.

Abstract: A method and system for providing a graphical user interface and trading system for professional electronic trading. A new professional trading application provides a back end trading platform that allows professional traders to quickly and efficiently execute electronic trades on one or more electronic trading exchanges. The new back end trading system eliminates much of the overhead included in most back end trading systems. A new graphical thermometer is for professional electronic trading is also presented.

Abstract: A method and apparatus for storing and using “register use” information to determine when a register is being used for the last time so that power savings may be achieved is disclosed. The register use information may take the form of “last read” information for a particular register. The last read information may be used to force the value of the register, after being read, to zero or to clock only that register while masking off the other registers. Several methods and hardware variations are disclosed for using the register use information to achieve power savings.

Abstract: Improved fixation devices for treating, for example, a radius fracture include a first member adapted to engage a distal portion of a radius fracture and a second member operably coupled to the first member adapted to engage a proximal portion of a radius fracture, wherein the first member is shiftable relative to the second member. Due to the adjustability of the first member relative to the second member, the linear distance, between the portion of bone proximal to the fracture and the portion of bone distal to the fracture can be fixed at a desired distance, which can promote suitable healing of the fracture.

Abstract: A method and apparatus for storing and using “register use” information to determine when a register is being used for the last time so that power savings may be achieved is disclosed. The register use information may take the form of “last read” information for a particular register. The last read information may be used to force the value of the register, after being read, to zero or to clock only that register while masking off the other registers. Several methods and hardware variations are disclosed for using the register use information to achieve power savings.

Abstract: A fishing rod extender adjustably holds a fishing rod on the side of a fishing boat. The fishing rod is retained in either an extended position during fishing or withdrawn in a retracted position closer to the boat when adjusting the reel, etc. The extending and retracting motion is undertaken by using a parallelogram frame or linkage pivotally attached at each of its four corners, having a base frame member or link rigidly mounted at an angle to the deck of a boat, and having the top frame or link member, parallel to the base, to move transversely in and out as the two interconnecting parallel frames or links rotate. A cylindrical collar attached to the top link near its outboard end receives the handle of the fishing rod.