Abstract: Methods, systems, and products are disclosed for displaying available menu choices in a multimodal browser including presenting a user a plurality of GUI menu fields; selecting one of the plurality of GUI menu fields; and displaying, in a GUI display box for the plurality of GUI menu fields, menu choices for the selected GUI menu field.

Abstract: Establishing a multimodal application voice including selecting a voice personality for the multimodal application and creating in dependence upon the voice personality a VoiceXML dialog. Selecting a voice personality for the multimodal application may also include retrieving a user profile and selecting a voice personality for the multimodal application in dependence upon the user profile. Selecting a voice personality for the multimodal application may also include retrieving a sponsor profile and selecting a voice personality for the multimodal application in dependence upon the sponsor profile. Selecting a voice personality for the multimodal application may also include retrieving a system profile and selecting a voice personality for the multimodal application in dependence upon the system profile.

Abstract: Methods, systems, and computer program products are provided for modifying a grammar of a hierarchical multimodal menu that include monitoring a user invoking a speech command in a first tier grammar, and adding the speech command to a second tier grammar in dependence upon the frequency of the user invoking the speech command. Adding the speech command to a second tier grammar may be carried out by adding the speech command to a higher tier grammar or by adding the speech command to a lower tier grammar. Adding the speech command to a second tier grammar may include storing the speech command in a grammar cache in the second tier grammar.

Abstract: Exemplary methods, systems, and products are disclosed for synchronizing visual and speech events in a multimodal application, including receiving from a user speech; determining a semantic interpretation of the speech; calling a global application update handler; identifying, by the global application update handler, an additional processing function in dependence upon the semantic interpretation; and executing the additional function. Typical embodiments may include updating a visual element after executing the additional function. Typical embodiments may include updating a voice form after executing the additional function. Typical embodiments also may include updating a state table after updating the voice form. Typical embodiments also may include restarting the voice form after executing the additional function.

Abstract: The present invention generally relates to microRNAs such as vertebrate microRNA (miRNA), for example, mammalian miRNA. Various aspects of the invention are directed to the detection, production, or expression of miRNA. In one aspect, the invention provides systems and methods for identifying targets of miRNA sequences. For instance, in one embodiment, gene sequences comprising UTRs are compared with miRNA sequences to determine the degree of interaction, for example, by determining a free energy measurement between the miRNA sequence and the UTR, and/or by determining complementarity between at least a portion of the miRNA sequence and the UTR. In another aspect, the invention is directed to the regulation of gene expression using miRNA. For example, gene expression within a cell may be altered by exposing the cell to an oligonucleotide comprising a sequence that is substantially antisense to at least a portion of an miRNA region of the gene, for example, antisense to a 6-mer or 7-mer portion of the miRNA.

Abstract: The present invention relates to compositions and methods for the prevention, prognostic evaluation, and treatment of oncogenic disorders, especially breast cancer, wherein a protein tyrosine kinase capable of complexing with a member of the SH2- and/or SH3-containing family of adaptor proteins is involved. In a preferred embodiment of the invention, the protein tyrosine kinase is the receptor protein tyrosine kinase HER2, and the adaptor protein is GRB, so that the protein tyrosine kinase/adaptor protein complex is a HER2/GRB-7 complex.

Abstract: The present invention relates to compositions and methods for the prevention, prognostic evaluation, and treatment of oncogenic disorders, especially breast cancer, wherein a protein tyrosine kinase capable of complexing with a member of the SH2- and/or SH3-containing family of adaptor proteins is involved. In a preferred embodiment of the invention, the protein tyrosine kinase is the receptor protein tyrosine kinase HER2, and the adaptor protein is GRB, so that the protein tyrosine kinase/adaptor protein complex is a HER2/GRB-7 complex.

Abstract: The present invention relates to compositions and methods for the prevention, prognostic evaluation, and treatment of oncogenic disorders, especially breast cancer, wherein a protein tyrosine kinase capable of complexing with a member of the SH2-and/or SH3-containing family of adaptor proteins is involved. In a preferred embodiment of the invention, the protein tyrosine kinase is the receptor protein tyrosine kinase HER2 or SHC polypeptide, and the adaptor protein is GRB-7, so that the protein tyrosine kinase/adaptor protein complex is a HER2/GRB-7 complex or a SHC/GRB-7 complex.

Abstract: A nestable box spring foundation includes support modules each formed of a single length of wire defining a top base, a bottom base, and four straight legs. The top base is welded to a wire grid assembly and includes two upper wire segments each having a straight wire portion and respective first and second curved end portions, each upper wire segment lying in a first plane with the straight wire portions lying in angularly converging mirror image relation to each other, each upper wire segment being spaced from one another with first end portions thereof lying closer together than second end portions thereof. The bottom base includes two straight lower wire segments lying in parallel relation to and in a second plane with one another and a straight cross wire segment fixedly intersecting orthogonally the lower wire segments proximate first ends thereof, with the first plane being parallel with the second plane.

Abstract: The present invention concerns methods for diagnosis and treatment of diseases or disorders characterized by abnormal cellular signal transduction involving a newly identified region, herein termed the "APB domain." APB domain binding between proteins is believed to play an important role in signal transduction pathways and, thereby, influence cellular events. Thus, APB mediated activity plays a role in signal transduction pathways and agents modulating APB mediated activity can be used to treat diseases or disorders involving proteins containing APB domains.