Patents by Inventor Benjamin Littler

Benjamin Littler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for Preparing Azabicyclic Compounds
    Publication number: 20120259129
    Abstract: The present invention relates to a process for preparing azabicyclic compounds that are useful intermediates for synthesizing pharmaceutical compounds or salts thereof.
    Type: Application
    Filed: March 9, 2012
    Publication date: October 11, 2012
    Applicant: Vertex Pharmaceuticals Incorporated
    Inventors: Narendra Bhalchandra Ambhaikar, Brian Richard Bear, Lev T. D. Fanning, Robert Hughes, Benjamin Littler
  • Process for Preparing Modulators of Cystic Fibrosis Transmembrane Conductance Regulator
    Publication number: 20110124869
    Abstract: The present invention relates to processes for preparing solid state forms of N-(4-(7-azabicyclo[2.2.1]heptan-7-yl)-2-(trifluoromethyl)phenyl)-4-oxo-5-(trifluoromethyl)-1,4-dihydroquinoline-3-carboxamide, including Compound 1 Form A, Compound 1 Form A-HCl, Compound 1 Form B, and Compound 1 Form B-HCl, any combination of these forms, pharmaceutical compositions thereof, and methods of treatment therewith.
    Type: Application
    Filed: October 21, 2010
    Publication date: May 26, 2011
    Applicant: Vertex Pharmaceuticals Incorporated
    Inventors: Narendra Bhalchandra Ambhaikar, Robert Hughes, Dennis James Hurley, Elaine Chungmin Lee, Benjamin Littler, Mehdi Numa, Stefanie Roeper, Urvi Sheth
  • Process for Preparing Azabicyclic Compounds
    Publication number: 20110065928
    Abstract: The present invention relates to a process for preparing azabicyclic compounds that are useful intermediates for synthesizing pharmaceutical compounds or salts thereof.
    Type: Application
    Filed: September 17, 2010
    Publication date: March 17, 2011
    Applicant: Vertex Pharmaceuticals Incorporated
    Inventors: Narendra Bhalchandra Ambhaikar, Brian Richard Bear, Lev T.D. Fanning, Robert Hughes, Benjamin Littler
  • Crystal Forms of (3R)-1-(2-Methylalanyl-D-Tryptophyl)-3-(Phenylmethyl)-3-Piperidinecarboxylic Acid 1,2,2-Trimethylhydrazide
    Publication number: 20110003996
    Abstract: Crystalline polymorphs of (3R)-1-(2-methylalanyl-D-tryptophyl)-3-(phenylmethyl)-3-piperidinecarboxylic acid 1,2,2-trimethylhydrazide which are useful as pharmaceutical agents are disclosed. Methods of production and isolation of these polymorphs and pharmaceutical compositions which include these polymorphs and pharmaceutical methods of treatment are also disclosed. The crystalline polymorphs of the present invention are useful as they act directly on the pituitary gland cells to release growth hormone.
    Type: Application
    Filed: July 6, 2010
    Publication date: January 6, 2011
    Applicant: Helsinn Therapeutics (U.S.), Inc.
    Inventors: Keith Lorimer, Seemon H. Pines, Bernhard Paul, Benjamin Littler
  • Crystal forms of (3R)-1-(2-methylalanyl-D-tryptophyl)-3-(phenylmethyl)-3-piperidinecarboxylic acid 1,2,2-trimethylhydrazide
    Patent number: 7825138
    Abstract: Crystalline polymorphs of (3R)-1-(2-methylalanyl-D-tryptophyl)-3-(phenylmethyl)-3-piperidinecarboxylic acid 1,2,2-trimethylhydrazide which are useful as pharmaceutical agents are disclosed. Methods of production and isolation of these polymorphs and pharmaceutical compositions which include these polymorphs and pharmaceutical methods of treatment are also disclosed. The crystalline polymorphs of the present invention are useful as they act directly on the pituitary gland cells to release growth hormone.
    Type: Grant
    Filed: June 22, 2005
    Date of Patent: November 2, 2010
    Assignee: Helsinn Therapeutics (U.S.), Inc.
    Inventors: Keith Lorimer, Seemon H. Pines, Bernhard Paul, Benjamin Littler
  • Processes for preparing biaryl ureas and analogs thereof
    Patent number: 7777048
    Abstract: The present invention relates to processes for preparing biaryl ureas derivatives and analogs thereof. The invention also provides compounds useful as intermediates in the processes of the present invention. The process is useful for preparing compounds that inhibit IMPDH.
    Type: Grant
    Filed: May 5, 2009
    Date of Patent: August 17, 2010
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Graham Ansell, Todd Blythe, Andrew Jones, Benjamin Littler, Adam Looker, Philip Nyce, John Snoonian
  • PROCESSES FOR PREPARING BIARYL UREAS AND ANALOGS THEREOF
    Publication number: 20090221835
    Abstract: The present invention relates to processes for preparing biaryl ureas derivatives and analogs thereof. The invention also provides compounds useful as intermediates in the processes of the present invention. The process is useful for preparing compounds that inhibit IMPDH.
    Type: Application
    Filed: May 5, 2009
    Publication date: September 3, 2009
    Inventors: Graham Ansell, Todd Blythe, Andrew Jones, Benjamin Littler, Adam Looker, Philip Nyce, John Snoonian
  • Processes for preparing biaryl ureas and analogs thereof
    Patent number: 7544810
    Abstract: The present invention relates to processes for preparing biaryl ureas derivatives and analogs thereof. The invention also provides compounds useful as intermediates in the processes of the present invention. The process is useful for preparing compounds that inhibit IMPDH.
    Type: Grant
    Filed: May 9, 2006
    Date of Patent: June 9, 2009
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Graham Ansell, Todd Blythe, Andrew Jones, Benjamin Littler, Adam Looker, Philip Nyce, John Snoonian
  • Processes for preparing biaryl ureas and analogs thereof
    Publication number: 20080021222
    Abstract: The present invention relates to processes for preparing biaryl ureas derivatives and analogs thereof. The invention also provides compounds useful as intermediates in the processes of the present invention. The process is useful for preparing compounds that inhibit IMPDH.
    Type: Application
    Filed: May 9, 2006
    Publication date: January 24, 2008
    Inventors: Graham Ansell, Todd Blythe, Andrew Jones, Benjamin Littler, Adam Looker, Philip Nyce, John Snoonian
  • Process for production of carebastine
    Publication number: 20060063933
    Abstract: Processes are disclosed for preparing piperidine derivative compounds of the formulae I, II or III:
    Type: Application
    Filed: September 17, 2004
    Publication date: March 23, 2006
    Applicant: AMR Technology, Inc.
    Inventors: Harold Meckler, Benjamin Littler, Prasad Raje, Michael Van Brunt, Paul Vogt
  • Catalytic hydrogenation of nitriles to produce capsaicinoid derivatives and amine compounds, and methods for purifying and obtaining the polymorphs thereof
    Publication number: 20060047171
    Abstract: Processes for preparing an amine compound by catalytically hydrogenating a precursor nitrile compound. In a particular aspect, the present hydrogenation process occurs in a dipolar organic solvent in the presence of a palladium/carbon catalyst and a strong anhydrous protic acid. In a further aspect, the preferred embodiment relates to a process for deprotecting a compound to produce an amine compound. In yet a further aspect, the preferred embodiment relates to amine products produced by the present processes. These amine products may be used for a variety of purposes.
    Type: Application
    Filed: August 27, 2004
    Publication date: March 2, 2006
    Inventors: Harold Meckler, Karl Popp, Bingidimi Mobele, Paul Isbester, Bruce Elder, Paul Vogt, Benjamin Littler, Stephen Eastham, David Reed, Luckner Ulysse, Michael Uttley