Abstract: The present invention provides optimized nucleic acid molecules, methods for optimization of nucleic acid molecules and uses of optimized nucleic acid molecules. A modular design principle is provided that is suitable to generate a nucleic acid, particularly mRNA, which is tailored for a respective application. The nucleic acid molecules of the present invention can be obtained by the versatile combination of multiple modules on nucleic acid level. Such nucleic acid, e.g. mRNA, can be tailored by combining one or more modules, comprising (i) a nucleic acid moiety encoding a polypeptide of interest (e.g. a protein potentially producing a therapeutic outcome) and (ii) at least one further coding or non-coding nucleic acid moiety, e.g.

Abstract: A method for project-oriented authentication of a device in a control system for a technical installation as part of an engineering project, wherein the control system includes at least one local registration service, at least one software inventory and a certification center, where information by the at least one local registration service with respect to what communication protocols and/or applications are supported by the device and/or are active is ascertained during authentication of the device within the control system, a project-oriented device certificate is requested from the first hierarchy of the certification center by the local registration service, and the project-oriented device certificate is deposited in an inventory element, associated with the engineering project, of the software inventory of the control system, the device certificates being issuable by the first hierarchy of the certification center have a unique project identifier.

Abstract: Control system and method for a technical plant, in particular a production or process plant, includes an operator station server and an operator station client connected to the operator station server, wherein the operator station client, at runtime of the plant, receive an instruction specified by the operator for an operator activity relating to the plant and a condition specified by the operator and which relates to an internal state of the plant for the instruction and transmit them to the operator station server, and the operator station server stores the instruction and condition received from the operator station client in memory and checks whether the condition is met, such that operators can adapt flexibly and efficiently to the operation and monitoring of the plant, particularly if it is formed in a modular manner for plant configurations that change during its life cycle.

Abstract: Industrial technical plant controlled and monitored by a process control, wherein a visualization system requests a history of selected process datum for that display period from a process control system and outputs the associated profile as a graphic forming process data points, where the visualization system determines the particular process data point as the average or median of the values of the selected process datum in a collection period characteristic of the particular process data point and where, for the particular process data point, the visualization system also determines the minimum and/or the maximum values of the selected process datum during the collection period such that whenever the minimum is below a predefined minimum value and/or the maximum exceeds a predefined maximum value, the visualization system indicates, together with the particular process data point, a secondary alarm not set by the process control system, but set by the visualization system.

Abstract: A method via which it is possible to identify a limited operator control is identified, monitoring of a technical plant is performed and in which a process is controlled via a process control system that includes at least two operator station servers and at least one operator station client, wherein process objects associated with the process are distributed to process images of different operator station servers of the process control system, where for process monitoring, a graphical user interface for displaying plant images with symbols associated with the process objects is provided on the operator station client.

Abstract: A method for visually displaying a facility mimic diagram of a technical facility which has an operator station server and an operator station client, wherein the method includes transferring the facility mimic diagram from the operator station server to the operator station client, where the facility mimic diagram includes an alarm signal indicator, communicating a duration for visually displaying the indicator, visually displaying the facility mimic diagram with the alarm signal indicator, informing the operator station client about an emergence of a new alarm signal in the management system via a message, determining a value an actual display time has to visually display the alarm signal indicator, determining whether a display time for the visual display of the alarm signal indicator with the new alarm signal would overshoot the value of the duration, limiting the visual display of the alarm signal indicator when the available duration is overshot.

Abstract: A control system for a technical plant, in particular a manufacturing or processing plant, wherein the control system is configured to initiate the issuance and revocation of certificates for components of the technical plant as part of certificate management, where the control system includes a computer-implemented revocation service which is configured to initiate the revocation of certificates in an event-controlled and automated manner.

Abstract: A control system for a technical plant, in particular a manufacturing or process plant, which has at least one engineering station server for creating a configuration for components of the technical plant and at least one operator station server for operator control and process monitoring of the configured components of the technical plant, wherein the engineering station server is configured to provide, starting from an already created configuration, a change made by a configuration planner to the already created configuration with at least one change indicator that indicates the change made to the configuration, and to send the at least one change indicator in addition to the changed configuration to the operator station server in order to send information concerning the changes made to the configuration to an operator using the operator station server.

Abstract: A control system for a process or manufacturing installation includes a first and second operator station servers, wherein one operator station server operates as master and the other of operates as slave that inherits master functionality when the master fails, respective data archives are implemented on the first and second operator station servers, the first and second operator station servers each receive data of the technical installation and record it in the respective data archive, and the first and second operator station servers each ascertain a respective health state, where the first and second operator station servers continuously record in the respective data archive, at specified time intervals, which health state the respective operator station server has when receiving and recording the data of the technical installation, and whether the respective operator station server acts as master or as slave in the respective time interval.

Abstract: A control system for a process or manufacturing installation includes a first and second operator station servers, wherein one operator station server operates as master and the other of operates as slave that inherits master functionality when the master fails, respective data archives are implemented on the first and second operator station servers, the first and second operator station servers each receive data of the technical installation and record it in the respective data archive, and the first and second operator station servers each ascertain a respective health state, where the first and second operator station servers continuously record in the respective data archive, at specified time intervals, which health state the respective operator station server has when receiving and recording the data of the technical installation, and whether the respective operator station server acts as master or as slave in the respective time interval.

Abstract: A method for operating a control system of a technical installation, wherein an operator station server transfers visualization information to an operator station client, and the operator station client generates a graphical presentation for an operator via the visualization information, where the method includes adjusting the graphical presentation via the operator station client in response to an instruction of the operator to the operator station client, transmitting the information regarding the adjustment of the graphical presentation to the operator station server via the operator station client, recording the information received from the operator station client regarding the adjustment of the graphical presentation in a memory of the operator station server, transmitting the information regarding the adjustment of the graphical presentation to the engineering station server via the operator station server, and presenting the information regarding the adjustment of the graphical presentation to a proje

Abstract: An operator station server of a technical installation upon which a certification service is implemented, wherein the certification service is configured to receive configuration information, which depends on a role of the operator station server in the technical installation, from at least one of (i) an engineering station server and (ii) a registration service of the technical installation, where the configuration information comprises information identifying which certificates of the certification service of the operator station server must be requested from a certification authority of the technical installation.

Abstract: A process control system includes an engineering system for a project configuration of hardware and software components of a process control system, an operator system having a runtime component for operator control and monitoring of a technical process, and an archive system for archiving project configuration inputs of the engineering system and for archiving operator inputs in the operator system, via which a project engineer and/or an operator may be provided with the relationships between engineering-relevant actions or events and runtime-relevant actions or events.

Abstract: A control system for a technical installation includes an operator station server and an operator station client, wherein the operator station server includes a visualization service for outputting image information to the operator station client, where the operator station server uses a first measured value associated with a first technical object of the technical installation and a second measured value associated with a second technical object of the technical installation to generate a scatter diagram with an operating point visualized in the scatter diagram, and where the operator station server transmits the scatter diagram with the operating point to the operator station client via the visualization service, where the control system provides the at least one operating point with a visual coding generated based on an alarm status and/or a quality status of the first measured value associated with the operating point and the second measured value.

Abstract: A method via which it is possible to identify a limited operator control is identified, monitoring of a technical plant is performed and in which a process is controlled via a process control system that includes at least two operator station servers and at least one operator station client, wherein process objects associated with the process are distributed to process images of different operator station servers of the process control system, where for process monitoring, a graphical user interface for displaying plant images with symbols associated with the process objects is provided on the operator station client.

Abstract: Industrial technical plant controlled and monitored by a process control, wherein a visualization system requests a history of selected process datum for that display period from a process control system and outputs the associated profile as a graphic forming process data points, where the visualization system determines the particular process data point as the average or median of the values of the selected process datum in a collection period characteristic of the particular process data point and where, for the particular process data point, the visualization system also determines the minimum and/or the maximum values of the selected process datum during the collection period such that whenever the minimum is below a predefined minimum value and/or the maximum exceeds a predefined maximum value, the visualization system indicates, together with the particular process data point, a secondary alarm not set by the process control system, but set by the visualization system.

Abstract: A method for event-oriented transmission of measured process values includes receiving the measured process values via an automation device of a control system of a process plant; automatically performing sensitization or desensitization of a measurement range of the measured process values on the automation device where, during sensitization or desensitization and depending on an undershoot of a minimal transmission rate of the measured process values from a measurement device to the automation device or an overshoot of a maximum transmission rate of the measured process values from the measurement device to the automation device, the measurement range is automatically decreased during sensitization and increased during desensitization by the automation device via a heuristic method, and transmitting the measured process values, on an event-oriented basis, to the operator station server of the control system of the process plant, where an event represents a predetermined change to the measured process values

Abstract: A method for visualizing process data in which a process control system controls and monitors an industrial technology plant, wherein the process control system automatically triggers a process alarm if the process data fulfills a trigger condition such a corresponding alarm message is transferred to an alarm system for output to an operator, triggered process data alarms are archived as a history, such that by selecting a process data item and specify a display period by the operator the alarm system simultaneously requests the history of the selected process data item process alarms assigned to a process object for the display period, where the alarm system outputs a time sequence of the process data item as a graphic and presents process data points in the graphic in an encoding that specifies for each process data point the highest priority with which process alarms have occurred during the acquisition period.

Abstract: A method for initially allocating and/or renewing certificates for devices and/or applications in a control system for a technical installation on the basis of certificates, wherein the devices and/or applications, within a framework of the initial allocation and/or renewal of the certificates, use a certificate management protocol to post a certificate request at at least one certification authority of the technical installation, where the devices and/or applications, in addition to the certificate management protocol, implement a certification service that generates a stateless alarm message and provides this generated stateless alarm message in the control system, when a certificate request previously posted by the device and/or the application is unanswered by the certification authority after expiration of a previously determined period of time.

Abstract: A computer-implemented method for representing operator control information in the context of a technical installation which includes at least one operator station server and one operator station client, wherein the method includes receiving measurement values of at least one technical object of the technical installation via the operator station server, continuously generating an actual trend progression of the measurement value, in the event that no measurement value can be received from the at least one technical object, an interpolation of the measurement value being undertaken to generate an interpolated trend progression, until a measurement value can be received once again, transferring the actual and the interpolated trend progression from the operator station server to the operator station client, and visually presenting the actual and the interpolated trend progression to an operator of the technical installation, preferably in a common trend progression diagram.