Abstract: An exemplary method may comprise receiving a matrix for a set of documents, each cell of the matrix including a frequency value indicating a number of instances of a corresponding text segment in a corresponding document, receiving an indication of a relationship between two text segments, each of the two text segments associated with a first column and a second column, respectively, of the matrix, adjusting, for each document, a frequency value of the second column based on the frequency value of the first column, projecting each frequency value into a reference space to generate a set of projection values, identifying a plurality of subsets of the reference space, clustering, for each subset of the plurality of subsets, at least some documents that correspond to projection values, and generating a graph of nodes, each of the nodes identifying one or more of the documents corresponding to each cluster.

Abstract: An exemplary method may comprise receiving a matrix for a set of documents, each cell of the matrix including a frequency value indicating a number of instances of a corresponding text segment in a corresponding document, receiving an indication of a relationship between two text segments, each of the two text segments associated with a first column and a second column, respectively, of the matrix, adjusting, for each document, a frequency value of the second column based on the frequency value of the first column, projecting each frequency value into a reference space to generate a set of projection values, identifying a plurality of subsets of the reference space, clustering, for each subset of the plurality of subsets, at least some documents that correspond to projection values, and generating a graph of nodes, each of the nodes identifying one or more of the documents corresponding to each cluster.

Abstract: An exemplary method may comprise receiving a matrix for a set of documents, each cell of the matrix including a frequency value indicating a number of instances of a corresponding text segment in a corresponding document, receiving an indication of a relationship between two text segments, each of the two text segments associated with a first column and a second column, respectively, of the matrix, adjusting, for each document, a frequency value of the second column based on the frequency value of the first column, projecting each frequency value into a reference space to generate a set of projection values, identifying a plurality of subsets of the reference space, clustering, for each subset of the plurality of subsets, at least some documents that correspond to projection values, and generating a graph of nodes, each of the nodes identifying one or more of the documents corresponding to each cluster.

Abstract: An exemplary method may comprise receiving a matrix for a set of documents, each cell of the matrix including a frequency value indicating a number of instances of a corresponding text segment in a corresponding document, receiving an indication of a relationship between two text segments, each of the two text segments associated with a first column and a second column, respectively, of the matrix, adjusting, for each document, a frequency value of the second column based on the frequency value of the first column, projecting each frequency value into a reference space to generate a set of projection values, identifying a plurality of subsets of the reference space, clustering, for each subset of the plurality of subsets, at least some documents that correspond to projection values, and generating a graph of nodes, each of the nodes identifying one or more of the documents corresponding to each cluster.

Abstract: DNA sequences comprising nucleic acids encoding fusion proteins comprising an Fc portion of an antibody attached at the N-terminus of an OB protein moiety, vectors comprising such DNA sequences, host cells comprising such vectors or DNA sequences, and processes for preparing such fusion proteins, and pharmaceutical compositions comprising such fusion proteins, are described.

Abstract: The present invention provides methods and compositions for treating excess weight by administering OB protein in a form for constant supply, at a dosage of less than or equal to about 1 mg protein/kg body weight/day. Compositions and methods used for production of recombinant murine and human OB protein are also provided. Compositions and methods for preparing recombinant murine methionyl OB protein and recombinant human methionyl OB protein, including DNA sequences, vectors, host cells, methods of fermentation, and methods of purification are provided herein.

Abstract: The present invention provides methods and compositions for, for example, effecting weight loss and treating excess weight by administering OB protein, or a derivative thereof, in a form for constant supply, for example, continuous administration, at a dosage of less than or equal to about 1 mg protein/kg body weight/day. Compositions and methods used for production of recombinant murine and human OB protein are also provided. Compositions and methods for preparing recombinant murine methionyl OB protein and recombinant human methionyl OB protein, including DNA sequences, vectors, host cells, methods of fermentation, and methods of purification are provided herein.

Abstract: The present invention provides methods of creating and using OB protein compositions with an antibody constant region or portion thereof fused to an OB protein. The fusion protein is created by attaching the polyamino acids to the OB protein moiety. The fusion proteins can then be used for various therapeutic uses.

Abstract: The present invention teaches compositions and methods relating to leptin fusion proteins comprising an antibody constant regions optionally attached to the N-terminus of the OB proteins. The compositions of the present invention may be used for treating obesity, diabetes, increasing lean muscle mass or for control of body composition.

Abstract: The present invention provides methods and compositions for treating excess weight by administering OB protein in a form for constant supply, at a dosage of less than or equal to about 1 mg protein/kg body weight/day. Compositions and methods used for production of recombinant murine and human OB protein are also provided. Compositions and methods for preparing recombinant murine methionyl OB protein and recombinant human methionyl OB protein, including DNA sequences, vectors, host cells, methods of fermentation, and methods of purification are provided herein.

Abstract: The present invention stems from the observation that administration of OB protein to non-obese as well as obese animals results in an increase of lean tissue mass. Thus, OB protein has the capacity to act, in addition to acting as a weight reducing agent, as an agent affecting lean tissue mass. As such, numerous lean tissue-mass increasing therapies are contemplated, even for patients who would not necessarily benefit from weight reduction. Thus, one aspect of the present invention is the use of OB protein (or analogs or derivatives thereof) for increasing lean tissue mass.

Abstract: The present invention provides methods of creating and using OB protein compositions with an antibody constant region or portion thereof fused to an OB protein. The fusion protein is created by attaching the polyamino acids to the OB protein moiety. The fusion proteins can then be used for various therapeutic uses.

Abstract: The present invention provides methods and compositions for treating excess weight by administering OB protein in a form for constant supply, at a dosage of less than or equal to about 1 mg protein/kg body weight/day. Compositions and methods used for production of recombinant murine and human OB protein are also provided. Compositions and methods for preparing recombinant murine methionyl OB protein and recombinant human methionyl OB protein, including DNA sequences, vectors, host cells, methods of fermentation, and methods of purification are provided herein.

Abstract: A closure for press-on application to, and rotational removal from, a container having a cylindrical neck which includes a plurality of vertically spaced helical threads formed in the outer surface thereof in generally parallel relationship to each other. A flexible cylindrical skirt, preferably composed of a polyolefin such as polypropylene, includes a plurality of radially inwardly projecting spaced lugs that are circumferentially disposed around the inner cylindrical skirt surface and axially spaced therefrom for engagement with the threads on the cylindrical neck of the container. The lugs are composed of a deformable plastic material and are sized so that when the closure is applied to the container, an interference fit is provided between at least some of the lugs and at least some of the threads.