Patents by Inventor Benjamin Mead

Benjamin Mead has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20230398130
    Abstract: The subject matter disclosed herein is generally directed to modulation of genes and pathways that drive differentiation of LGR5+ stem cells. The methods and compositions can be used to treat diseases associated with aberrant epithelial barrier function. Using novel screening methods Applicants have identified compounds that increase Paneth cell differentiation. The compounds can be used to treat diseases associated with stem cell differentiation.
    Type: Application
    Filed: October 25, 2021
    Publication date: December 14, 2023
    Inventors: Benjamin Mead, Alexander K. Shalek, Jeffrey Karp, Kazuki Hattori
  • Publication number: 20220404340
    Abstract: Described in certain example embodiments herein are systems, methods, and uses thereof for high-throughput in vitro evaluating multiple test compounds in parallel for biological or pharmacological functions. In certain embodiments, the system allows the selection of a subset of test compounds from a group of test compounds to form an optimized pool, and methods are provided to use such optimized pool of test compounds to identify and validate therapeutic agents for treating diseases and driving guided differentiation of stem cells into desired types of cells. The systems described herein can provide, for example, a cost-effective and high-quality high-throughput approach for drug screening.
    Type: Application
    Filed: October 23, 2020
    Publication date: December 22, 2022
    Inventors: Benjamin Mead, Conner Samuel Kummerlowe, Alexander K. Shalek
  • Publication number: 20220323406
    Abstract: The subject matter disclosed herein is generally directed to modulation of genes and pathways that drive differentiation of LGR5+ stem cells. The methods and compositions can be used to treat diseases associated with aberrant epithelial barrier function.
    Type: Application
    Filed: June 5, 2020
    Publication date: October 13, 2022
    Inventors: Benjamin Mead, Alexander K. Shalek, Jeffrey Karp, Kazuki Hattori
  • Patent number: 8782364
    Abstract: Data elements are stored at a plurality of nodes. Each data element is a member data element of one of a plurality of layouts. Each layout indicates a unique subset of nodes. All member data elements of the layout are stored on each node in the unique subset of nodes. A stored dependency list includes every layout that has member data elements. The dependency list is used to determine availability of data elements based on ability to access data from nodes from the plurality of nodes.
    Type: Grant
    Filed: December 13, 2011
    Date of Patent: July 15, 2014
    Assignee: Hewlett-Packard Development Company, L.P.
    Inventors: Benjamin Mead Vandiver, Lyric Pankaj Doshi
  • Publication number: 20130151773
    Abstract: Data elements are stored at a plurality of nodes. Each data element is a member data element of one of a plurality of layouts. Each layout indicates a unique subset of nodes. All member data elements of the layout are stored on each node in the unique subset of nodes. A stored dependency list includes every layout that has member data elements. The dependency list is used to determine availability of data elements based on ability to access data from nodes from the plurality of nodes.
    Type: Application
    Filed: December 13, 2011
    Publication date: June 13, 2013
    Inventors: Benjamin Mead Vandiver, Lyric Pankaj Doshi