Abstract: The present invention provides a method of diagnosing a CNS disorder comprising administering a fluorescent marker of retinal integrity to a subject and generating an image of the subject's eye, wherein the fluorescent marker is delivered by intranasal administration is also provided and fluorescent markers of retinal integrity for use in such methods. Also provided is a pharmaceutical composition comprising an annex in or a functional fragment or derivative thereof conjugated to a compound of 2 kDa or less, wherein the composition comprises annex in or a functional fragment or derivative thereof conjugated at a concentration of at least mg/ml.

Abstract: A resealable closure for a container in which package integrity is indicated by a structure which connects the closure to a remaining portion of the container which must be broken in order to gain access to the contents of the container for a first time. The package integrity feature, in one form, includes a structure associated with the closure, wherein upon opening the closure for a first time, the structure stretches, increasing a length of the structure until the structure eventually breaks, leaving one or both residual ends of the broken structure rippled or curved upward from the remainder of the container. In one alternative form, the structure is associated with a pull tab of the sealing panel, which comprises the closure, whereby either the structure must be broken first, prior to pulling back the sealing panel, or while pulling back the sealing panel for a first time, the structure breaks, prior to gaining access to the contents therein.

Abstract: A resealable closure for a container in which package integrity is indicated by a structure which connects the closure to a remaining portion of the container which must be broken in order to gain access to the contents of the container for a first time. The package integrity feature, in one form, includes a structure associated with the closure, wherein upon opening the closure for a first time, the structure stretches, increasing a length of the structure until the structure eventually breaks, leaving one or both residual ends of the broken structure rippled or curved upward from the remainder of the container. In one alternative form, the structure is associated with a pull tab of the sealing panel, which comprises the closure, whereby either the structure must be broken first, prior to pulling back the sealing panel, or while pulling back the sealing panel for a first time, the structure breaks, prior to gaining access to the contents therein.

Abstract: A resealable closure for a container in which package integrity is indicated by a structure which connects the closure to a remaining portion of the container which must be broken in order to gain access to the contents of the container for a first time. The package integrity feature, in one form, includes a structure associated with the closure, wherein upon opening the closure for a first time, the structure stretches, increasing a length of the structure until the structure eventually breaks, leaving one or both residual ends of the broken structure rippled or curved upward from the remainder of the container. In one alternative form, the structure is associated with a pull tab of the sealing panel, which comprises the closure, whereby either the structure must be broken first, prior to pulling back the sealing panel, or while pulling back the sealing panel for a first time, the structure breaks, prior to gaining access to the contents therein.

Abstract: A resealable closure for a container in which package integrity is indicated by a structure which connects the closure to a remaining portion of the container which must be broken in order to gain access to the contents of the container for a first time. The package integrity feature, in one form, includes a structure associated with the closure, wherein upon opening the closure for a first time, the structure stretches, increasing a length of the structure until the structure eventually breaks, leaving one or both residual ends of the broken structure rippled or curved upward from the remainder of the container. In one alternative form, the structure is associated with a pull tab of the sealing panel, which comprises the closure, whereby either the structure must be broken first, prior to pulling back the sealing panel, or while pulling back the sealing panel for a first time, the structure breaks, prior to gaining access to the contents therein.

Abstract: A resealable closure for a container in which package integrity is indicated by a structure which connects the closure to a remaining portion of the container which must be broken in order to gain access to the contents of the container for a first time. The package integrity feature, in one form, includes a structure associated with the closure, wherein upon opening the closure for a first time, the structure stretches, increasing a length of the structure until the structure eventually breaks, leaving one or both residual ends of the broken structure rippled or curved upward from the remainder of the container. In one alternative form, the structure is associated with a pull tab of the sealing panel, which comprises the closure, whereby either the structure must be broken first, prior to pulling back the sealing panel, or while pulling back the sealing panel for a first time, the structure breaks, prior to gaining access to the contents therein.

Abstract: Automatic control of transmitted power of a transmitted signal at a local transmitter in response to intermittent signal quality reports from a remote receiver about a received communication signal originating as the transmitted communication signal is provided by distinguishing between improving link conditions and degrading link conditions and at least derating a scheduled signal power change if there are changes in the signal quality reports, such as if the power change is scheduled to occur too soon after a previous signal power change. A fast attack power increase and slow decay power decrease may also be employed. The method is designed to maintain signal quality (e.g. distant Es/No) in the presence of these variations and uncertainties, for time-varying link conditions that have a fade rate range from less than 0.01 dB/s to more than 1 dB/s.