Abstract: The present invention relates to elafibranor for use for the treatment of Primary Biliary Cholangitis (PBC) in a subject having PBC with a baseline plasma alkaline phosphatase (ALP) level of more than 1×ULN (Upper Limit Normal) and strictly less than t 1.67×ULN, before receiving elafibranor.

Abstract: Carbon fiber reinforced polymers (CFRPs) are increasingly replacing traditional materials in the automobile, aerospace, and energy sectors. Developing end-of-life processes that retain the value of both carbon fibers and the polymer matrix is essential. This study presents a strategy to upcycle pre- and post-consumer polystyrene-containing CFRPs, crosslinked with unsaturated polyesters or vinyl esters, into benzoic acid. The thermoset matrix is upgraded via biocatalysis using an engineered strain of Aspergillus nidulans, producing valuable secondary metabolites, such as (2Z,4Z,6E)-octa-2,4,6-trienoic acid. The process preserves much of the carbon fiber sizing, enabling the fibers to be remanufactured into new composite coupons with mechanical properties comparable to virgin substrates. This represents the first system to reclaim significant value from both the fiber and polymer matrix of CFRPs.

Abstract: A photonic device including a filter comprising an electrically switchable array, wherein the electrically switchable array includes alternating layers of polymer and polymer-dispersed liquid crystal, wherein the electrically switchable array is tunable under an applied electric field.

Abstract: The invention provides methods for assessing one or more predetermined characteristics or properties of a microfluidic droplet within a microfluidic channel, and regulating one or more fluid flow rates within that channel to selectively alter the predetermined microdroplet characteristic or property using a feedback control.

Abstract: A lighting system uses an existing track receiver for holding standard panel trim to hold an elongate linear light. The elongate linear light provides illumination and conceals the gap between panels. The light includes a snap track with arcuate portions that contact the panels. Between the arcuate portions is a trough portion that receives and retains an elongate luminaire strip. The trough portion has a narrow opening formed from the opposite ends of the arcuate portions which is complementary to side profile surfaces on the luminaire. The luminaire is retained only by the narrow opening engaging with the side profile surfaces. A snap-in cover conceals the terminal end of the snap track.

Abstract: In an example method, a computer system accesses first data representing a plurality of characteristics of test subjects, and second data representing a plurality of candidate propensity score models that can be used for estimating an effectiveness of a treatment. The system selects a set of propensity score models by sequentially evaluating at least some of the candidate propensity score models until one or more stop criteria are satisfied. The effectiveness of the treatment can be estimated by utilizing the selected set of propensity score models. Further, the system stores a data structure representing the set of propensity score models, and outputs the data structure.

Abstract: The invention provides methods for assessing one or more predetermined characteristics or properties of a microfluidic droplet within a microfluidic channel, and regulating one or more fluid flow rates within that channel to selectively alter the predetermined microdroplet characteristic or property using a feedback control.

Abstract: The present disclosure describes photonic materials that reversibly change color in response to the material being stretched or otherwise mechanically deformed.

Abstract: The present invention concerns elafibranor for use for the treatment of Primary Biliary Cholangitis (PBC) in a subject with PBC and with liver cirrhosis, and preferably a subject having Child-Pugh score A or having Child-Pugh score B.

Abstract: A photonic device including a filter comprising an electrically switchable array, wherein the electrically switchable array includes alternating layers of polymer and polymer-dispersed liquid crystal, wherein the electrically switchable array is tunable under an applied electric field.

Abstract: The present disclosure describes photonic materials that reversibly change color in response to the material being stretched or otherwise mechanically deformed.

Abstract: The present disclosure describes photonic materials that reversibly change color in response to the material being stretched or otherwise mechanically deformed.

Abstract: A tool bit including a drive portion, a tip, and a body. The drive portion is disposed at a first end of the tool bit and is configured to be coupled to a tool. The tip is disposed at a second end of the tool bit opposite from the drive portion. The tip includes a target region treated by laser peening. The target region is spaced from an end of the tip. The body extends between the drive portion and the tip.

Abstract: An apparatus, methods, and a system for a photonic biosensor are disclosed. The photonic biosensor includes a substrate having a sample addition zone in fluid communication with a wicking zone and a sample detection zone. The substrate also includes an optical input port configured to optically couple to a light source and an optical output port configured to optically couple to a light detector. The photonic biosensor also includes a photonic integrated circuit (“PIC”) connected to the substrate. The PIC includes a first grating coupler aligned with the optical input port, a second grating coupler aligned with the optical output port, at least one waveguide between the first grating coupler and the second grating coupler, and at least one detection element disposed within the at least one waveguide.

Abstract: An exemplary bolt assembly includes a housing, a bolt, and a magnetic sensor. The housing includes a tubular sleeve configured for mounting in a latch bore of a door. The bolt is movably mounted to the housing for movement between an extended position and a retracted position. The magnetic sensor includes wires that extend through the tubular sleeve, and is operable to transmit information relating to an open/closed position of the door.

Abstract: A tool bit including a drive portion having a first maximum outer dimension, a tip having a second maximum outer dimension, a shank extending between the drive portion and the tip, and a sleeve. The shank has a third maximum outer dimension that is less than first and second maximum outer dimensions. The sleeve extends from the drive portion to the tip and surrounds the shank. The sleeve engages a portion of the shank such that the sleeve is inhibited from moving relative to the shank.

Abstract: A handle assembly to receive a collet of a tap assembly or a die includes a body defining a non-circular aperture and an axis of rotation that extends through the non-circular aperture. The non-circular aperture is configured to receive the collet of the tap assembly or the die. The handle assembly also includes a grip extending radially from the body and a retainer disposed in the body. The retainer includes an engagement member and a biasing member that biases the engagement member toward the axis of rotation. The retainer is configured to releasably secure the collet of the tap assembly or the die within the non-circular aperture.

Abstract: An exemplary bolt assembly includes a housing, a bolt, and a magnetic sensor. The housing includes a tubular sleeve configured for mounting in a latch bore of a door. The bolt is movably mounted to the housing for movement between an extended position and a retracted position. The magnetic sensor includes wires that extend through the tubular sleeve, and is operable to transmit information relating to an open/closed position of the door.

Abstract: Safety guards for use with a bed rail are disclosed. A safety guard may be coupled to a mattress without being coupled to a bed rail, or a safety guard may be coupled to a mattress and to a bed rail. The safety guards may reduce a risk of entrapment between the mattress and the bed rail by distributing weight on the mattress across a wide surface area. A safety guard may be disposed underneath a sheet on the mattress. The safety guard may remain coupled to the mattress without inhibiting changing of sheets on the mattress.