Abstract: The present invention concerns elafibranor for use for the treatment of Primary Biliary Cholangitis (PBC) in a subject with PBC and with liver cirrhosis, and preferably a subject having Child-Pugh score A or having Child-Pugh score B.

Abstract: A winch utility includes a main body, the main body including a shell, the shell defining an enclosure; an electric motor mounted to and contained within at least a portion of the shell; a controller attached to an inner part of the shell and in electronic communication with the electric motor; and a bobbin coupled to the electric motor; and a cable coupled to the bobbin at a bobbin end, the cable defining a terminal end distal to the bobbin end, the cable arranged to be coiled around the bobbin by rotation of the electric motor, wherein the terminal end of the cable is arranged outside of the shell, wherein the controller is configured to instruct the electric motor.

Abstract: An under-counter water filtration assembly, including methods for performing the same, may include a filter housing, a filter element, and a powered water valve. The filter housing may define an inlet port, a filtered outlet port, and an unfiltered outlet port. The filtered outlet port and the unfiltered outlet port may be defined downstream from the inlet port. The filter element may be mounted within the filter housing upstream from the filtered outlet port. The filter element may be bypassed by the unfiltered outlet port. The powered water valve may be mounted within the filter housing in fluid communication between the inlet port and the unfiltered outlet port to selectively restrict a water flow therethrough.

Abstract: A winch utility for hoisting a payload up a track section includes a main body comprising: a shell, the shell defining an enclosure; a powertrain assembly comprising an electric motor contained within at least a portion of the shell; a controller attached to an inner part of the shell and in electronic communication with the electric motor; and a bobbin coupled to the electric motor; a shelf portion comprising a shelf and a rim, the shelf configured to support the payload, the rim configured to protect the payload on the shelf from falling; and an arm assembly coupling the shelf to the main body, the arm assembly comprising an arm oriented at an acute angle relative to the shelf.

Abstract: An ice making assembly for a refrigerator appliance includes a support frame and a tray. A mold cavity is defined in the tray. The tray is rotatably mounted inside of the support frame. The tray is rotatable between a fill position and a release position. The mold cavity is configured to receive a fill of liquid water and form an ice piece therein when the tray is in the fill position.

Abstract: A photonic device including a filter comprising an electrically switchable array, wherein the electrically switchable array includes alternating layers of polymer and polymer-dispersed liquid crystal, wherein the electrically switchable array is tunable under an applied electric field.

Abstract: An icemaker appliance includes a container defining a liquid reservoir, an ice mold selectively received within a portion of the liquid reservoir, a temperature sensor provided within the liquid reservoir and configured to monitor a temperature of the liquid, a water level sensor provided within the liquid reservoir and configured to determine a level of the liquid within the container, and a controller attached to the container, the controller being operably connected with the temperature sensor and the water level sensor, the controller including a wireless communication module configured to wirelessly communicate with a remote terminal.

Abstract: The present disclosure describes photonic materials that reversibly change color in response to the material being stretched or otherwise mechanically deformed.

Abstract: The present disclosure describes photonic materials that reversibly change color in response to the material being stretched or otherwise mechanically deformed.

Abstract: Organizing and publishing content in a content management system wherein content, including text, images and video, is received and segmented into content atoms. One or more tags are associated with the content atoms to allow device specific presentation of the content atoms.

Abstract: A tool bit including a drive portion, a tip, and a body. The drive portion is disposed at a first end of the tool bit and is configured to be coupled to a tool. The tip is disposed at a second end of the tool bit opposite from the drive portion. The tip includes a target region treated by laser peening. The target region is spaced from an end of the tip. The body extends between the drive portion and the tip.

Abstract: An apparatus, methods, and a system for a photonic biosensor are disclosed. The photonic biosensor includes a substrate having a sample addition zone in fluid communication with a wicking zone and a sample detection zone. The substrate also includes an optical input port configured to optically couple to a light source and an optical output port configured to optically couple to a light detector. The photonic biosensor also includes a photonic integrated circuit (“PIC”) connected to the substrate. The PIC includes a first grating coupler aligned with the optical input port, a second grating coupler aligned with the optical output port, at least one waveguide between the first grating coupler and the second grating coupler, and at least one detection element disposed within the at least one waveguide.

Abstract: An exemplary bolt assembly includes a housing, a bolt, and a magnetic sensor. The housing includes a tubular sleeve configured for mounting in a latch bore of a door. The bolt is movably mounted to the housing for movement between an extended position and a retracted position. The magnetic sensor includes wires that extend through the tubular sleeve, and is operable to transmit information relating to an open/closed position of the door.

Abstract: Systems and techniques for goal optimized process scheduler are described herein. A set of processes may be obtained from a plurality of process engines. Process data may be identified for each member of the set of processes. Goal data may be obtained for a goal. The goal data may indicate elements for attainment of the goal by completion of one or more processes of the set of processes. A process schedule may be generated for the set of processes based on the goal data. The process schedule may be optimized through removal of processes from the process schedule by comparison of the process data to the goal data. The optimized process schedule may include a linear organization of processes for attainment of the goal. An optimized process schedule workflow may be created for display on a user interface of a computing device.

Abstract: A tool bit including a drive portion having a first maximum outer dimension, a tip having a second maximum outer dimension, a shank extending between the drive portion and the tip, and a sleeve. The shank has a third maximum outer dimension that is less than first and second maximum outer dimensions. The sleeve extends from the drive portion to the tip and surrounds the shank. The sleeve engages a portion of the shank such that the sleeve is inhibited from moving relative to the shank.

Abstract: A handle assembly to receive a collet of a tap assembly or a die includes a body defining a non-circular aperture and an axis of rotation that extends through the non-circular aperture. The non-circular aperture is configured to receive the collet of the tap assembly or the die. The handle assembly also includes a grip extending radially from the body and a retainer disposed in the body. The retainer includes an engagement member and a biasing member that biases the engagement member toward the axis of rotation. The retainer is configured to releasably secure the collet of the tap assembly or the die within the non-circular aperture.

Abstract: An icemaker appliance includes a container defining a liquid reservoir, an ice mold selectively received within a portion of the liquid reservoir, a temperature sensor provided within the liquid reservoir and configured to monitor a temperature of the liquid, a water level sensor provided within the liquid reservoir and configured to determine a level of the liquid within the container, and a controller attached to the container, the controller being operably connected with the temperature sensor and the water level sensor, the controller including a wireless communication module configured to wirelessly communicate with a remote terminal.

Abstract: An apparatus comprises: a clamshell configured for holding an electrochemical cell having first and second terminals, the clamshell comprising at least first and second portions hinged to each other; first and second contacts positioned for contacting the first and second terminals, respectively; and a thermoelectric device mounted to the clamshell for controlling a temperature of the electrochemical cell.

Abstract: A refrigerator appliance, as disclosed herein, may include a cabinet, a door, a dispensing assembly, an ice-making assembly, and an ice storage bin. The door may define a dispenser recess having a transverse opening extending vertically from a top recess end to a bottom recess end and laterally from a first recess side to a second recess side. The dispensing assembly may be positioned within the dispenser recess and define an ice delivery passage. The ice-making assembly may be attached to the cabinet. The ice storage bin may include a bin body defining a storage cavity. The bin body may be selectively mounted to the door within the dispenser recess to receive ice from the dispensing assembly. The bin body may extend vertically from the top recess end to the bottom recess end and laterally from the first recess side to the second recess side.

Abstract: An exemplary bolt assembly includes a housing, a bolt, and a magnetic sensor. The housing includes a tubular sleeve configured for mounting in a latch bore of a door. The bolt is movably mounted to the housing for movement between an extended position and a retracted position. The magnetic sensor includes wires that extend through the tubular sleeve, and is operable to transmit information relating to an open/closed position of the door.