Abstract: Provided herein is an apparatus having a first tubular body, a second tubular body disposable within the first tubular body, a first plurality of fenestrations in fluid communication with a gallbladder lumen, and an expandable body disposed around the first plurality of fenestrations. The first plurality of fenestrations is configured to deliver a phase changing ablation medium by spraying the phase changing ablation medium in a spatially diffuse pattern into the space defined by the expandable body between the first plurality of fenestrations and the wall of the gallbladder. The first tubular body and the second tubular body define an annular flow path. A pressure sensor measures intraluminal pressure of the gallbladder. A control unit is coupled to the pressure sensor.

Abstract: A molding subsystem includes a reconfigurable mold and a control subsystem. The reconfigurable mold includes one or more plates, with each plate including: a plurality of pins defining a molding surface of the reconfigurable mold; a frame which defines a plurality of channels for receiving the plurality of pins; and a plurality of actuators for moving the plurality of pins in a first axial direction. The control subsystem includes a controller operably connected to the plurality of actuators of each plate, such that the controller can communicate instructions to and/or obtain readings therefrom. The molding surface of each plate can be manipulated in response to pin movement to facilitate the manufacture of articles of different shape and dimension. Output data corresponding to a digital model of an article placed in the reconfigurable mold can be generated based on readings obtained by the plurality of actuators of each plate.

Abstract: Provided herein are catheter devices, systems, and methods to ablate a tissue location. The devises, systems, and methods disclosed herein comprise catheters comprising a fenestrated nozzle, ablation balloons, and an ablation medium that is directed at a tissue location.