Patents by Inventor Benjamin Moritz

Benjamin Moritz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHOD FOR THE SELECTION OF A LONG-TERM PRODUCING CELL USING HISTONE ACYLATION AS MARKERS
    Publication number: 20230016623
    Abstract: Herein is reported a method for determining methylation of a promoter nucleic acid operably linked to a nucleic acid encoding a polypeptide and thereby determining the long-term productivity of a cell. Also an aspect is a method for selecting a cell for producing a polypeptide by determining the methylation of the promoter nucleic acid operably linked to the structural gene encoding the polypeptide.
    Type: Application
    Filed: April 15, 2022
    Publication date: January 19, 2023
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Ulrich Goepfert, Peter Becker, Benjamin Moritz
  • Method for the selection of a long-term producing cell using histone acylation as markers
    Patent number: 11332797
    Abstract: Herein is reported a method for determining methylation of a promoter nucleic acid operably linked to a nucleic acid encoding a polypeptide and thereby determining the long-term productivity of a cell. Also an aspect is a method for selecting a cell for producing a polypeptide by determining the methylation of the promoter nucleic acid operably linked to the structural gene encoding the polypeptide.
    Type: Grant
    Filed: May 13, 2015
    Date of Patent: May 17, 2022
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Ulrich Goepfert, Peter Becker, Benjamin Moritz
  • CMV PROMOTER AND METHOD FOR PRODUCTION OF POLYPEPTIDES
    Publication number: 20190360014
    Abstract: The current invention reports a promoter that has the nucleic acid sequence of SEQ ID NO: 02 or SEQ ID NO: 03 which is a human CMV major immediate-early (hCMV-MIE) promoter/enhancer with C to G point mutation at position ?41 and/or ?179 relative to the transcription start site. This new promoter is especially useful for the production of polypeptides at large scale as it shows reduced promoter silencing and improved polypeptide production.
    Type: Application
    Filed: May 3, 2019
    Publication date: November 28, 2019
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Ulrich Goepfert, Benjamin Moritz
  • CMV promoter and method for production of polypeptides
    Patent number: 10329595
    Abstract: The current invention reports a promoter that has the nucleic acid sequence of SEQ ID NO: 02 or SEQ ID NO: 03 which is a human CMV major immediate-early (hCMV-MIE) promoter/enhancer with C to G point mutation at position ?41 and/or ?179 relative to the transcription start site. This new promoter is especially useful for the production of polypeptides at large scale as it shows reduced promoter silencing and improved polypeptide production.
    Type: Grant
    Filed: November 18, 2016
    Date of Patent: June 25, 2019
    Assignee: HOFFMANN-LA ROCHE INC.
    Inventors: Ulrich Goepfert, Benjamin Moritz
  • Method for the Selection of a Long-Term Producing Cell using Histone Acylation as Markers
    Publication number: 20170081732
    Abstract: Herein is reported a method for determining methylation of a promoter nucleic acid operably linked to a nucleic acid encoding a polypeptide and thereby determining the long-term productivity of a cell. Also an aspect is a method for selecting a cell for producing a polypeptide by determining the methylation of the promoter nucleic acid operably linked to the structural gene encoding the polypeptide.
    Type: Application
    Filed: May 13, 2015
    Publication date: March 23, 2017
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Ulrich Goepfert, Peter Becker, Benjamin Moritz
  • METHOD FOR PRODUCTION OF POLYPEPTIDES
    Publication number: 20170067087
    Abstract: The current invention reports a promoter that has the nucleic acid sequence of SEQ ID NO: 02 or SEQ ID NO: 03 which is a human CMV major immediate-early (hCMV-MIE) promoter/enhancer with C to G point mutation at position ?41 and/or ?179 relative to the transcription start site. This new promoter is especially useful for the production of polypeptides at large scale as it shows reduced promoter silencing and improved polypeptide production.
    Type: Application
    Filed: November 18, 2016
    Publication date: March 9, 2017
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Ulrich Goepfert, Benjamin Moritz