Patents by Inventor Benjamin Moritz GRAF

Benjamin Moritz GRAF has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Fatty acid synthase, inhibitors and modifications thereof and its use
    Patent number: 12509682
    Abstract: In a first aspect, the present invention relates to new recombinant polypeptides derived from the newly identified gamma subunit of the fatty acid synthase protein complex. In addition, a fatty acid synthase protein complex comprising these new recombinant polypeptides are disclosed as well as nucleic acid molecules encoding these polypeptides. Further, a host cells containing the nucleic acid molecule encoding the polypeptides according to the present invention or expressing the polypeptide according to the present invention are described. In addition, an isolated fatty acid synthase protein complex is disclosed containing the newly identified gamma subunit thereof. Moreover, methods for determining the suitability of candidate compounds capable of inhibiting either the ketoreductase, enoylreductase or malonyl/palmitoyl transferase present in the FAS protein complex and methods for designing inhibitors of said enzymes are disclosed.
    Type: Grant
    Filed: March 20, 2020
    Date of Patent: December 30, 2025
    Assignee: MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUND DER WISSENSCHAFTEN E.V.
    Inventors: Ashwin Chari, Holger Stark, Kashish Singh, Benjamin Moritz Graf
  • FATTY ACID SYNTHASE, INHIBITORS AND MODIFICATIONS THEREOF AND ITS USE
    Publication number: 20220154181
    Abstract: In a first aspect, the present invention relates to new recombinant polypeptides derived from the newly identified gamma subunit of the fatty acid synthase protein complex. In addition, a fatty acid synthase protein complex comprising these new recombinant polypeptides are disclosed as well as nucleic acid molecules encoding these polypeptides. Further, a host cells containing the nucleic acid molecule encoding the polypeptides according to the present invention or expressing the polypeptide according to the present invention are described. In addition, an isolated fatty acid synthase protein complex is disclosed containing the newly identified gamma subunit thereof. Moreover, methods for determining the suitability of candidate compounds capable of inhibiting either the ketoreductase, enoylreductase or malonyl/palmitoyl transferase present in the FAS protein complex and methods for designing inhibitors of said enzymes are disclosed.
    Type: Application
    Filed: March 20, 2020
    Publication date: May 19, 2022
    Inventors: Ashwin CHARI, Holger STARK, Kashish SINGH, Benjamin Moritz GRAF