Abstract: The simplification of neural network models is described. For example, a method for simplifying a neural network model includes providing the neural network model to be simplified, defining a first temporal filter for the conveyance of input from a neuron to an other spatially-extended neuron along the arborized projection, defining a second temporal filter for the conveyance of input from yet another neuron to the spatially-extended neuron along the arborized projection, replacing, in the neural network model, the first, spatially-extended neuron with a first, spatially-constrained neuron and the arborized projection with a first connection extending between the first, spatially-constrained neuron and the second neuron, wherein the first connection filters input from the second neuron in accordance with the first temporal filter and a second connection extending between the first spatially-constrained neuron and the third neuron.

Abstract: The invention relates to a boom-arm segment fora concrete pump, wherein the boom-arm segment (30) comprises a side part (35, 36)-which extends between a top chord (33) and a bottom chord (34) of the boom-arm segment (30). In the side part (35, 36), a bent portion is formed such that a first portion (42, 43) of the side part (35, 36) has a lateral offset (56) relative to a second portion (44) of the side part (35, 36). A transition portion (45, 46) forms a connection between the first portion (42, 43) and the second portion (44). The boom-arm segment (30) comprises a reinforcement part (40, 50), the material thickness of which spans the lateral offset (56) between the first portion (42, 43) and the second portion (44). The reinforcement part (40, 50) is butt-joined to the transition portion (45, 46). The invention also relates to a method for producing a boom-arm segment (30).

Abstract: The substrates supported in substrate holders are carried on holder carriers in a manner, that their extended surfaces are exposed to the surrounding atmosphere along an extended surface of the holder carriers. The holder carriers include an axis traverse to their extended surface. The substrates on a holder carrier are vacuum treated in a vacuum treatment chamber. This chamber communicates via a gate valve with a transfer vacuum chamber. A holder carrier with substrates in the vacuum treatment chamber is exchanged with a holder carrier carrying untreated substrates from the transfer vacuum chamber 23 by means of an exchange robot. During treatment in the vacuum treatment chamber, holder carriers with treated substrates and holder carriers with untreated substrates are exchanged in the transfer vacuum chamber through a gate valve. The transfer vacuum chamber acts as a load-lock.

Abstract: In an embodiment, the optoelectronic semiconductor component (1) comprises a semiconductor layer sequence (2) with an active zone (22) for generating a radiation. On an bottom side (20) of the semiconductor layer sequence (2) there is an electrically insulating separation layer (3) with several openings (32). An adhesion-promoting layer (4) is located next to the openings (32) on a side of the separation layer (3) facing away from the semiconductor layer sequence (2). A continuous metallization layer (5) is located on a side of the adhesion-promoting layer (4) facing away from the semiconductor layer sequence (2). The semiconductor layer sequence (2) is electrically contacted in the openings (32) directly by the metallization layer (5). The metallization layer (5) and the openings (32) are spaced from the active zone (22) in the direction perpendicular to the separation layer (3).

Abstract: An alignment system for approaching a vehicle to a target object spatially spaced therefrom, including an object detection device attached to the vehicle and a coupling element, which in an end position detachably holds the target object, the object detection device being aligned in the direction of the target object and the data from the object detection device being used to generate an image in which the target object together with a guide marker can be seen during the approach of the vehicle. The guide marker is applied to at least one component of the vehicle arranged in an entry area of the coupling element.

Abstract: This invention generally relates to the field of somatic gene therapy. The invention provides a nucleic acid construct comprising a transgene encoding a therapeutic protein, a tetracycline-responsive aptazyme sequence, and inverted terminal repeats (ITRs). The nucleic acid construct can be transferred to a subject in need thereof in the form of a viral vector, in particular an adeno-associated virus (AAV) vector. The Tet-responsive aptazyme sequence allows for a tightly controlled expression of the transgene in the subject, thereby avoiding toxic side effects. The nucleic acid construct and the viral vectors comprising same are particularly useful in the treatment of proliferative diseases like cancer.

Abstract: The invention provides a set of novel Single domain VHH antibodies against SARS-CoV-2 (SEQ ID N? 1-6) and their use to detect and neutralize the wild type virus.

Abstract: A coupling device for a towing vehicle with an object detection device attached to the coupling device, wherein the coupling device has a coupling body in form of a fifth wheel plate and a locking mechanism, with which a coupling device in form of a kingpin is releasably held on the coupling body in its end position (E), wherein the coupling body includes an available space which is limited by a coupling device guiding contour and extends along a longitudinal axis (x), wherein the coupling device is at least partially immersed during coupling into the available space until reaching an end position (E).

Abstract: A method for producing a fibrous composite material component, in particular for a vehicle. According to the method, at least one dry woven fabric layer is initially provided, wherein the woven fabric layer includes carbon fibers. A binder is then applied to the woven fabric layer. Further, the woven fabric layer is reshaped into a preform layer, wherein the binder is activated during the reshaping and the woven fabric is stabilized in the reshaped shape. The preform layer is then applied to further woven fabric layers in order to strengthen the shape. The connection of the preform layer and the further woven fabric layers thus results in a preform, which is inserted into a molding tool for carrying out an RTM process. Then, the RTM process is carried out in order to obtain a fibrous composite material component.

Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for reconstructing and simulating neocortical microcircuitry. In one aspect, a method includes providing a model of neural tissue, the model including different types of neural cells and dynamic synaptic interconnections between the neural cells, changing a parameter in the model; and identifying a change in a computational state of the model of the neural tissue responsive to the change in the parameter. The change in the parameter can, e.g., change behavior of neural cells of at least one type, change interconnectivity between neural cells, or target a location within a volume in the model that interacts with multiple types of neural cells.

Abstract: A laser scanner and a system with a laser scanner for measuring an environment. The laser scanner includes an optical distance measuring device, a support, a beam steering unit rotatably fixed to the support which rotates around a beam axis of rotation. The beam steering unit includes a mirrored surface which deflects radiation used in the optical distance measurement and an angle encoder for recording angle data. The optical distance measurement is performed by a progressive rotation of the beam steering unit about the beam axis of rotation and the continuous emission of a distance measurement radiation, the emission being made through an outlet area arranged in the direction of the mirrored surface on the support, the receiving optics for receiving radiation are arranged on the support, and wherein the outlet area has a lateral offset with respect to the optical axis of the receiving optics.

Abstract: A laser scanner and a system with a laser scanner for measuring an environment. The laser scanner includes an optical distance measuring device, a support, a beam steering unit rotatably fixed to the support which rotates around a beam axis of rotation. The beam steering unit includes a mirrored surface which deflects radiation used in the optical distance measurement and an angle encoder for recording angle data. The optical distance measurement is performed by a progressive rotation of the beam steering unit about the beam axis of rotation and the continuous emission of a distance measurement radiation, the emission being made through an outlet area arranged in the direction of the mirrored surface on the support, the receiving optics for receiving radiation are arranged on the support, and wherein the outlet area has a lateral offset with respect to the optical axis of the receiving optics.

Abstract: A laser scanner and a system with a laser scanner for measuring an environment. The laser scanner includes an optical distance measuring device, a support, a beam steering unit rotatably fixed to the support which rotates around a beam axis of rotation. The beam steering unit includes a mirrored surface which deflects radiation used in the optical distance measurement and an angle encoder for recording angle data. The optical distance measurement is performed by a progressive rotation of the beam steering unit about the beam axis of rotation and the continuous emission of a distance measurement radiation, the emission being made through an outlet area arranged in the direction of the mirrored surface on the support, the receiving optics for receiving radiation are arranged on the support, and wherein the outlet area has a lateral offset with respect to the optical axis of the receiving optics.

Abstract: A laser scanner and a system with a laser scanner for measuring an environment. The laser scanner includes an optical distance measuring device, a support, a beam steering unit rotatably fixed to the support which rotates around a beam axis of rotation. The beam steering unit includes a mirrored surface which deflects radiation used in the optical distance measurement and an angle encoder for recording angle data. The optical distance measurement is performed by a progressive rotation of the beam steering unit about the beam axis of rotation and the continuous emission of a distance measurement radiation, the emission being made through an outlet area arranged in the direction of the mirrored surface on the support, the receiving optics for receiving radiation are arranged on the support, and wherein the outlet area has a lateral offset with respect to the optical axis of the receiving optics.

Abstract: A laser scanner and a system with a laser scanner for measuring an environment. The laser scanner includes an optical distance measuring device, a support, a beam steering unit rotatably fixed to the support which rotates around a beam axis of rotation. The beam steering unit includes a mirrored surface which deflects radiation used in the optical distance measurement and an angle encoder for recording angle data. The optical distance measurement is performed by a progressive rotation of the beam steering unit about the beam axis of rotation and the continuous emission of a distance measurement radiation, the emission being made through an outlet area arranged in the direction of the mirrored surface on the support, the receiving optics for receiving radiation are arranged on the support, and wherein the outlet area has a lateral offset with respect to the optical axis of the receiving optics.

Abstract: A laser scanner and a system with a laser scanner for measuring an environment. The laser scanner includes an optical distance measuring device, a support, a beam steering unit rotatably fixed to the support which rotates around a beam axis of rotation. The beam steering unit includes a mirrored surface which deflects radiation used in the optical distance measurement and an angle encoder for recording angle data. The optical distance measurement is performed by a progressive rotation of the beam steering unit about the beam axis of rotation and the continuous emission of a distance measurement radiation, the emission being made through an outlet area arranged in the direction of the mirrored surface on the support, the receiving optics for receiving radiation are arranged on the support, and wherein the outlet area has a lateral offset with respect to the optical axis of the receiving optics.

Abstract: A laser scanner and a system with a laser scanner for measuring an environment. The laser scanner includes an optical distance measuring device, a support, a beam steering unit rotatably fixed to the support which rotates around a beam axis of rotation. The beam steering unit includes a mirrored surface which deflects radiation used in the optical distance measurement and an angle encoder for recording angle data. The optical distance measurement is performed by a progressive rotation of the beam steering unit about the beam axis of rotation and the continuous emission of a distance measurement radiation, the emission being made through an outlet area arranged in the direction of the mirrored surface on the support, the receiving optics for receiving radiation are arranged on the support, and wherein the outlet area has a lateral offset with respect to the optical axis of the receiving optics.

Abstract: A method of reducing the pressure of a liquid includes the steps of providing a conduit containing a packing material, such that a large number of small passages are formed in the packing material, and passing the liquid through the conduit and the packing material. The amount of packing material through which the liquid flows can be varied to vary the pressure drop experienced by the liquid passing through the packing material. The reduction in pressure achieved may be stepwise (discrete) or continuous. The method may be used to reduce the pressure of an aqueous polymer solution for use in a polymer flood technique for oil extraction, and allows the pressure to be reduced without damage to the polymer.

Abstract: The invention provides an apparatus for increasing a number concentration of molecules of an analyte of interest in real time from a sample gas flow containing ionised molecules of the analyte, aerosol particles and other molecules, the apparatus comprising: an ion-concentrating chamber having: an inlet for receiving the sample gas flow; an ion outlet; and at least one other outlet; the ion-concentrating chamber being connected or connectable to a gas flow generating and controlling device for establishing a gas flow velocity field within the ion-concentrating chamber to direct the aerosol particles and other molecules of the sample gas flow to the at least one other outlet; and one or more electrodes arranged in an axially spaced apart manner along the ion-concentrating chamber for creating an electric field within the ion-concentrating chamber to direct the ionised analyte molecules in the sample gas flow to the ion outlet, wherein the electrodes are configured such that an absolute value of the stren

Abstract: The simplification of neural network models is described. For example, a method for simplifying a neural network model includes providing the neural network model to be simplified, defining a first temporal filter for the conveyance of input from a neuron to an other spatially-extended neuron along the arborized projection, defining a second temporal filter for the conveyance of input from yet another neuron to the spatially-extended neuron along the arborized projection, replacing, in the neural network model, the first, spatially-extended neuron with a first, spatially-constrained neuron and the arborized projection with a first connection extending between the first, spatially-constrained neuron and the second neuron, wherein the first connection filters input from the second neuron in accordance with the first temporal filter and a second connection extending between the first spatially-constrained neuron and the third neuron.