Patents by Inventor Benjamin Neil Gray
Benjamin Neil Gray has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230242925Abstract: Compositions and methods for modifying genomic DNA sequences are provided. The methods produce double-stranded breaks (DSBs) at pre-determined target sites in a genomic DNA sequence, resulting in mutation, insertion, and/or deletion of DNA sequences at the target site(s) in a genome. Compositions comprise DNA constructs comprising nucleotide sequences that encode a Cms1 protein operably linked to a promoter that is operable in the cells of interest. The DNA constructs can be used to direct the modification of genomic DNA at pre-determined genomic loci. Methods to use these DNA constructs to modify genomic DNA sequences are described herein. Additionally, compositions and methods for modulating the expression of genes are provided.Type: ApplicationFiled: March 3, 2023Publication date: August 3, 2023Applicant: BENSON HILL, INC.Inventors: Matthew Begemann, Benjamin Neil Gray
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Patent number: 11624070Abstract: Compositions and methods for modifying genomic DNA sequences are provided. The methods produce double-stranded breaks (DSBs) at pre-determined target sites in a genomic DNA sequence, resulting in mutation, insertion, and/or deletion of DNA sequences at the target site(s) in a genome. Compositions comprise DNA constructs comprising nucleotide sequences that encode a Cms1 protein operably linked to a promoter that is operable in the cells of interest. The DNA constructs can be used to direct the modification of genomic DNA at pre-determined genomic loci. Methods to use these DNA constructs to modify genomic DNA sequences are described herein. Additionally, compositions and methods for modulating the expression of genes are provided.Type: GrantFiled: September 29, 2020Date of Patent: April 11, 2023Assignee: BENSON HILL, INC.Inventors: Matthew Begemann, Benjamin Neil Gray
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Publication number: 20230002761Abstract: Compositions and methods for targeting pre-determined DNA sequences in bacterial cells are provided. The methods result in the targeted elimination of bacterial cells that comprise the pre-determined DNA sequence(s). Compositions comprise DNA constructs comprising nucleotide sequences that encode a Cms1 protein operably linked to a promoter that is operable in the cells of interest. Methods to use these DNA constructs to selectively target and eliminate bacterial cells that harbor the targeted DNA sequence(s) are described herein.Type: ApplicationFiled: November 19, 2020Publication date: January 5, 2023Applicant: BENSON HILL, INC.Inventors: Benjamin Neil Gray, Gina Christine Neumann
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Patent number: 11371053Abstract: Compositions and methods for improving plant growth are provided herein. Disclosed herein are polypeptides encompassing m-type thioredoxin proteins, and polynucleotides encoding m-type thioredoxin proteins, wherein the thioredoxin protein-encoding sequence is expressed from mesophyll-preferred promoters. Also provided herein are expression constructs for expressing genes of interest whose expression may improve agronomic properties including but not limited to crop yield, biotic and abiotic stress tolerance, and early vigor, plants comprising the polynucleotides, polypeptides, and expression constructs, and methods of producing transgenic plants.Type: GrantFiled: June 28, 2017Date of Patent: June 28, 2022Assignee: Benson Hill, Inc.Inventors: Benjamin Neil Gray, Henry D. Priest
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Patent number: 11359207Abstract: Compositions and methods for improving plant growth are provided herein. Polynucleotides encoding glutaredoxin proteins, polypeptides encompassing glutaredoxin proteins, and expression constructs for expressing genes of interest whose expression may improve agronomic properties including but not limited to crop yield, biotic and abiotic stress tolerance, and early vigor, plants comprising the polynucleotides, polypeptides, and expression constructs, and methods of producing transgenic plants are also provided.Type: GrantFiled: August 15, 2018Date of Patent: June 14, 2022Assignee: BENSON HILL, INC.Inventor: Benjamin Neil Gray
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Patent number: 11060102Abstract: Compositions and methods for improving plant growth are provided herein. Polynucleotides encoding photosystem I reaction center subunit N (PSAN) proteins, polypeptides encompassing PSAN proteins, and expression constructs for expressing genes of interest whose expression may improve agronomic properties including but not limited to crop yield, biotic and abiotic stress tolerance, and early vigor, plants comprising the polynucleotides, polypeptides, and expression constructs, and methods of producing transgenic plants are also provided.Type: GrantFiled: June 14, 2017Date of Patent: July 13, 2021Assignee: BENSON HILL, INC.Inventors: Benjamin Neil Gray, Henry D. Priest
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Patent number: 11008583Abstract: Compositions and methods for improving plant growth are provided herein. Polynucleotides encoding ADP-glucose pyrophosphorylase small subunit (AGPaseSS) proteins, polypeptides encompassing AGPaseSS proteins, and expression constructs for expressing genes of interest whose expression may improve agronomic properties including but not limited to crop yield, biotic and abiotic stress tolerance, and early vigor, plants comprising the polynucleotides, polypeptides, and expression constructs, and methods of producing transgenic plants are also provided.Type: GrantFiled: June 14, 2017Date of Patent: May 18, 2021Assignee: Benson Hill, Inc.Inventor: Benjamin Neil Gray
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Patent number: 10982223Abstract: Compositions and methods for improving plant growth are provided herein. Polynucleotides encoding phenylalanine ammonia lyase (PAL) proteins, polypeptides encompassing PAL proteins, and expression constructs for expressing genes of interest whose expression may improve agronomic properties including but not limited to crop yield, biotic and abiotic stress tolerance, and early vigor, plants comprising the polynucleotides, polypeptides, and expression constructs, and methods of producing transgenic plants are also provided.Type: GrantFiled: June 12, 2017Date of Patent: April 20, 2021Assignee: Benson Hill, Inc.Inventors: Benjamin Neil Gray, Henry D. Priest
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Publication number: 20210024943Abstract: Compositions and methods for modifying genomic DNA sequences are provided. The methods produce double-stranded breaks (DSBs) at pre-determined target sites in a genomic DNA sequence, resulting in mutation, insertion, and/or deletion of DNA sequences at the target site(s) in a genome. Compositions comprise DNA constructs comprising nucleotide sequences that encode a Cms1 protein operably linked to a promoter that is operable in the cells of interest. The DNA constructs can be used to direct the modification of genomic DNA at pre-determined genomic loci. Methods to use these DNA constructs to modify genomic DNA sequences are described herein. Additionally, compositions and methods for modulating the expression of genes are provided.Type: ApplicationFiled: September 29, 2020Publication date: January 28, 2021Applicant: BENSON HILL, INC.Inventors: Matthew Begemann, Benjamin Neil Gray
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Patent number: 10837023Abstract: Compositions and methods for modifying genomic DNA sequences are provided. The methods produce double-stranded breaks (DSBs) at pre-determined target sites in a genomic DNA sequence, resulting in mutation, insertion, and/or deletion of DNA sequences at the target site(s) in a genome. Compositions comprise DNA constructs comprising nucleotide sequences that encode a Cms1 protein operably linked to a promoter that is operable in the cells of interest. The DNA constructs can be used to direct the modification of genomic DNA at pre-determined genomic loci. Methods to use these DNA constructs to modify genomic DNA sequences are described herein. Additionally, compositions and methods for modulating the expression of genes are provided.Type: GrantFiled: April 24, 2019Date of Patent: November 17, 2020Assignee: BENSON HILL, INC.Inventors: Matthew Begemann, Benjamin Neil Gray
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Publication number: 20200308597Abstract: Compositions and methods for improving plant growth are provided herein. Polynucleotides encoding ADP-glucose pyrophosphorylase small subunit (AGPaseSS) proteins, polypeptides encompassing AGPaseSS proteins, and expression constructs for expressing genes of interest whose expression may improve agronomic properties including but not limited to crop yield, biotic and abiotic stress tolerance, and early vigor, plants comprising the polynucleotides, polypeptides, and expression constructs, and methods of producing transgenic plants are also provided.Type: ApplicationFiled: June 14, 2017Publication date: October 1, 2020Applicant: Benson Hill Biosystems, Inc.Inventor: Benjamin Neil Gray
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Publication number: 20200291416Abstract: Compositions and methods for improving plant growth are provided herein. Polynucleotides encoding quinone oxidoreductase proteins, polypeptides encompassing quinone oxidoreductase proteins, and expression constructs for expressing genes of interest whose expression may improve agronomic properties including but not limited to crop yield, biotic and abiotic stress tolerance, and early vigor, plants comprising the polynucleotides, polypeptides, and expression constructs, and methods of producing transgenic plants are also provided.Type: ApplicationFiled: November 20, 2018Publication date: September 17, 2020Applicant: BENSON HILL, INC.Inventor: Benjamin Neil Gray
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Publication number: 20200255850Abstract: Compositions and methods for improving plant growth are provided herein. Polynucleotides encoding glutaredoxin proteins, polypeptides encompassing glutaredoxin proteins, and expression constructs for expressing genes of interest whose expression may improve agronomic properties including but not limited to crop yield, biotic and abiotic stress tolerance, and early vigor, plants comprising the polynucleotides, polypeptides, and expression constructs, and methods of producing transgenic plants are also provided.Type: ApplicationFiled: August 15, 2018Publication date: August 13, 2020Applicant: BENSON HILL, INC.Inventor: Benjamin Neil Gray
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Publication number: 20200165622Abstract: Compositions and methods for improving plant growth are provided herein. Polynucleotides encoding thioredoxin proteins, polypeptides encompassing thioredoxin proteins, and expression constructs for expressing genes of interest whose expression may improve agronomic properties including but not limited to crop yield, biotic and abiotic stress tolerance, and early vigor, plants comprising the polynucleotides, polypeptides, and expression constructs, and methods of producing transgenic plants are also provided.Type: ApplicationFiled: June 28, 2017Publication date: May 28, 2020Applicant: Benson Hill Biosystems, Inc.Inventors: Benjamin Neil Gray, Henry D. Priest
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Publication number: 20200149058Abstract: Compositions and methods for improving plant growth are provided herein. Polynucleotides encoding phenylalanine ammonia lyase (PAL) proteins, polypeptides encompassing PAL proteins, and expression constructs for expressing genes of interest whose expression may improve agronomic properties including but not limited to crop yield, biotic and abiotic stress tolerance, and early vigor, plants comprising the polynucleotides, polypeptides, and expression constructs, and methods of producing transgenic plants are also provided.Type: ApplicationFiled: June 12, 2017Publication date: May 14, 2020Applicant: BENSON HILL BIOSYSTEMS, INC.Inventors: Benjamin Neil Gray, Henry D. Priest
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Patent number: 10590430Abstract: Compositions and methods for increasing plant growth for higher crop yield are provided. The methods involve the expression of at least one ictB coding sequence in a C4 plant of interest. Further provided are methods for expressing at least one ictB coding sequence and increasing the expression of at least one additional coding sequence of interest selected from CO2 assimilating sequences, such as those sequences involved in the Calvin Benson cycle, starch synthesis pathway, and C4 carbon shuttle in the plant. C4 plants expressing an ictB sequence are encompassed by the invention. Additionally, plants expressing an ictB sequence and those plants showing increased expression of a sequence of interest are encompassed by the invention. The expression of ictB in the C4 plant and the co-expression of ictB with this additional gene or genes results in yield gains.Type: GrantFiled: June 7, 2018Date of Patent: March 17, 2020Assignee: Benson Hill, Inc.Inventors: Benjamin Neil Gray, Matthew Begemann
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Publication number: 20200032286Abstract: Compositions and methods for increasing plant growth for higher crop yield are provided. The methods involve the expression of at least one ictB coding sequence in a C4 plant of interest. Further provided are methods for expressing at least one ictB coding sequence and increasing the expression of at least one additional coding sequence of interest selected from CO2 assimilating sequences, such as those sequences involved in the Calvin Benson cycle, starch synthesis pathway, and C4 carbon shuttle in the plant. C4 plants expressing an ictB sequence are encompassed by the invention. Additionally, plants expressing an ictB sequence and those plants showing increased expression of a sequence of interest are encompassed by the invention. The expression of ictB in the C4 plant and the co-expression of ictB with this additional gene or genes results in yield gains.Type: ApplicationFiled: October 1, 2019Publication date: January 30, 2020Applicant: BENSON HILL BIOSYSTEMS, INC.Inventors: Benjamin Neil Gray, Matthew Begemann
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Publication number: 20190338296Abstract: Compositions and methods for modifying genomic DNA sequences are provided. The methods produce double-stranded breaks (DSBs) at pre-determined target sites in a genomic DNA sequence, resulting in mutation, insertion, and/or deletion of DNA sequences at the target site(s) in a genome. Compositions comprise DNA constructs comprising nucleotide sequences that encode a Cms1 protein operably linked to a promoter that is operable in the cells of interest. The DNA constructs can be used to direct the modification of genomic DNA at pre-determined genomic loci. Methods to use these DNA constructs to modify genomic DNA sequences are described herein. Additionally, compositions and methods for modulating the expression of genes are provided.Type: ApplicationFiled: April 24, 2019Publication date: November 7, 2019Applicant: BENSON HILL BIOSYSTEMS, INC.Inventors: Matthew Begemann, Benjamin Neil Gray
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Publication number: 20190233839Abstract: Compositions and methods for improving plant growth are provided herein. Polynucleotides encoding photosystem I reaction center subunit N (PSAN) proteins, polypeptides encompassing PSAN proteins, and expression constructs for expressing genes of interest whose expression may improve agronomic properties including but not limited to crop yield, biotic and abiotic stress tolerance, and early vigor, plants comprising the polynucleotides, polypeptides, and expression constructs, and methods of producing transgenic plants are also provided.Type: ApplicationFiled: June 14, 2017Publication date: August 1, 2019Applicant: Benson Hill Biosystems, Inc.Inventors: Benjamin Neil Gray, Henry D. Priest
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Patent number: 10316324Abstract: Compositions and methods for modifying genomic DNA sequences are provided. The methods produce double-stranded breaks (DSBs) at pre-determined target sites in a genomic DNA sequence, resulting in mutation, insertion, and/or deletion of DNA sequences at the target site(s) in a genome. Compositions comprise DNA constructs comprising nucleotide sequences that encode a Cms1 protein operably linked to a promoter that is operable in the cells of interest. The DNA constructs can be used to direct the modification of genomic DNA at pre-determined genomic loci. Methods to use these DNA constructs to modify genomic DNA sequences are described herein. Additionally, compositions and methods for modulating the expression of genes are provided.Type: GrantFiled: August 8, 2018Date of Patent: June 11, 2019Assignee: Benson Hill Biosystems, Inc.Inventors: Matthew Begemann, Benjamin Neil Gray