Patents by Inventor Benjamin Nicholson
Benjamin Nicholson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Publication number: 20230365641Abstract: The present invention relates to targeted, masked cytokines, comprising a cytokine or functional fragment thereof, a masking moiety, a targeting moiety and a proteolytically cleavable linker. The targeting moiety comprises an antigen-binding moiety that specifically binds to an antigen expressed on the surface of a target cell The masking moiety masks the cytokine or functional fragment thereof thereby reducing or preventing binding of the cytokine or functional fragment thereof to its cognate receptor, but upon proteolytic cleavage of the cleavable linker at a target site, the cytokine or functional fragment thereof becomes activated, which renders it capable or more capable of binding to its cognate receptor.Type: ApplicationFiled: February 28, 2023Publication date: November 16, 2023Inventors: Parker Johnson, Ertan Eryilmaz, Dheeraj Tomar, Benjamin Nicholson, Kurt Jenkins, Carl Uli Bialucha
-
Publication number: 20230062119Abstract: The present invention includes methods of identifying a patient who will likely be responsive to treatment with a protein arginine N-methyltransferase 5 inhibitor, or a pharmaceutically acceptable salt thereof, and methods of treating the same.Type: ApplicationFiled: December 16, 2020Publication date: March 2, 2023Applicant: Merck Sharp & Dohme LLCInventors: Benjamin Nicholson, Rachel Allison Altura, Razvan Cristescu, David John Curtis, Ian Philip Street
-
Patent number: 8680139Abstract: Disclosed are novel compounds which are useful as therapeutics, especially in anti-neoplastic therapy and in other therapeutic regimes where cysteine protease inhibition is implicated.Type: GrantFiled: March 31, 2010Date of Patent: March 25, 2014Assignee: ProgenraInventors: Ping Cao, Joseph Weinstock, William D. Kingsbury, Craig A. Leach, Suresh Kumar Kizhakkethil-George, Benjamin Nicholson
-
Publication number: 20130273027Abstract: Mutant enzymes and methods of use thereof are provided.Type: ApplicationFiled: March 13, 2013Publication date: October 17, 2013Inventors: Craig Leach, Michael Eddins, David Stemer, Benjamin Nicholson
-
Publication number: 20120114765Abstract: Disclosed are novel compounds which are useful as therapeutics, especially in anti-neoplastic therapy and in other therapeutic regimes where cysteine protease inhibition is implicated.Type: ApplicationFiled: March 31, 2010Publication date: May 10, 2012Inventors: Ping Cao, Joseph Weinstock, William D. Kingsbury, Craig A. Leach, Suresh Kumar Kizhakkethil-George, Benjamin Nicholson
-
Publication number: 20110143958Abstract: Methods for identifying ubiquitin ligases and ubiquitin ligase modulators are disclosed. The methods comprise combining the components of a ubiquitylation reaction and using proteins that contain motifs that recognize ubiquitylated sites in the detection of ubiquitylation.Type: ApplicationFiled: July 23, 2009Publication date: June 16, 2011Inventors: Jeffrey Gordon Marblestone, Benjamin Nicholson, Suresh Kumar Kizhakkethil-George
-
Patent number: 7935704Abstract: Compounds represented by the following structure (I) are disclosed: as are methods for making such compounds, wherein said methods comprise reacting a diacyldiketopiperazine with a first aldehyde to produce an intermediate compound; and reacting the intermediate compound with a second aldehyde to produce the class of compounds with the generic structure, where the first aldehyde and the second aldehydes are selected from the group consisting of an oxazolecarboxaldeyhyde, imidazolecarboxaldehyde, a benzaldehyde, imidazolecarboxaldehyde derivatives, and benzaldehyde derivatives, thereby forming the above compound wherein R1, R1?, R1?, R2, R3, R4, R5, and R6, X1 and X2, Y, Z, Z1, Z2, Z3, and Z4 may each be separately defined in a manner consistent with the accompanying description. Compositions and methods for treating vascular proliferation are also disclosed.Type: GrantFiled: February 4, 2005Date of Patent: May 3, 2011Assignee: Nereus Pharmaceuticals, Inc.Inventors: Michael A. Palladino, George Kenneth Lloyd, Yoshio Hayashi, Benjamin Nicholson
-
Patent number: 7879892Abstract: Disclosed herein are various novel oxazolidinone, imidazolidinone, and thiazolidinone analogs and methods of treating cancer and/or microbial infection using these analogs. Particular 4-oxazolidinone compounds are shown to have anti-cancer and anti-microbial activity.Type: GrantFiled: May 21, 2008Date of Patent: February 1, 2011Assignee: Nereus Pharmaceuticals, Inc.Inventors: Venkata Rami Reddy Macherla, Benjamin Nicholson, Kin Sing Lam
-
Publication number: 20100021941Abstract: Methods for identifying ubiquitin ligases and ubiquitin ligase modulators are disclosed. The methods comprise combining the components of a ubiquitylation reaction and using proteins that contain motifs that recognize ubiquitylated sites in the detection of ubiquitylation.Type: ApplicationFiled: July 23, 2009Publication date: January 28, 2010Applicant: PROGENRA, INCORPORATEDInventors: Jeffrey Gordon Marblestone, Suresh Kumar Kizhakkethil-George, Benjamin Nicholson
-
Patent number: 7544814Abstract: Compounds of Formulae I-VI and derivatives thereof having anti-cancer, anti-inflammatory, and anti-microbial properties and to compositions that include one or more of compounds and their derivatives or analogs having anti-cancer, anti-inflammatory and anti-microbial properties are disclosed. Pharmaceutical compositions comprising such compounds and methods of treating cancer, inflammatory conditions, and microbial infections with the disclosed compounds or the disclosed pharmaceutical compositions are also disclosed.Type: GrantFiled: October 1, 2007Date of Patent: June 9, 2009Assignee: Nereus Pharmaceuticals, Inc.Inventors: Barbara Christine Potts, Venkat Macherla, Scott Sherman Mitchell, Ram Rao Manam, Katherine A. McArthur, Kin Sing Lam, Saskia Neuteboom, Ta-Hsiang Chao, Benjamin Nicholson, Cheryl L. Billstrom
-
Publication number: 20080221183Abstract: Disclosed herein are various novel oxazolidinone, imidazolidinone, and thiazolidinone analogs and methods of treating cancer and/or microbial infection using these analogs. Particular 4-oxazolidinone compounds are shown to have anti-cancer and anti-microbial activity.Type: ApplicationFiled: May 21, 2008Publication date: September 11, 2008Applicant: NEREUS PHARMACEUTICALS, INC.Inventors: Venkata Rami Reddy Macherla, Benjamin Nicholson, King Sing Lam
-
Publication number: 20080221182Abstract: Disclosed herein are various novel oxazolidinone, imidazolidinone, and thiazolidinone analogs and methods of treating cancer and/or microbial infection using these analogs. Particular 4-oxazolidinone compounds are shown to have anti-cancer and anti-microbial activity.Type: ApplicationFiled: May 21, 2008Publication date: September 11, 2008Applicant: NEREUS PHARMACEUTICALS, INC.Inventors: Venkata Rami Reddy Macherla, Benjamin Nicholson, Kin Sing Lam
-
Patent number: 7378530Abstract: Disclosed herein are various novel oxazolidinone, imidazolidinone, and thiazolidinone analogs and methods of treating cancer and/or microbial infection using these analogs. Particular 4-oxazolidinone compounds are shown to have anti-cancer and anti-microbial activity.Type: GrantFiled: February 21, 2006Date of Patent: May 27, 2008Assignee: Nereus Pharmaceuticals, Inc.Inventors: Venkata Rami Reddy Macherla, Benjamin Nicholson, Kin Sing Lam
-
Publication number: 20080070969Abstract: Compounds of Formulae I-VI and derivatives thereof having anti-cancer, anti-inflammatory, and anti-microbial properties and to compositions that include one or more of compounds and their derivatives or analogs having anti-cancer, anti-inflammatory and anti-microbial properties are disclosed. Pharmaceutical compositions comprising such compounds and methods of treating cancer, inflammatory conditions, and microbial infections with the disclosed compounds or the disclosed pharmaceutical compositions are also disclosed.Type: ApplicationFiled: October 1, 2007Publication date: March 20, 2008Applicant: Nereus Pharmaceuticals, Inc.Inventors: Barbara Potts, Venkat Macherla, Scott Mitchell, Ram Manam, Katherine Reed, Kin Lam, Saskia Neuteboom, Ta-Hsiang Chao, Benjamin Nicholson, Cheryl Billstrom
-
Patent number: 7276530Abstract: Compounds of Formulae I-VI and derivatives thereof having anti-cancer, anti-inflammatory, and anti-microbial properties and to compositions that include one or more of compounds and their derivatives or analogs having anti-cancer, anti-inflammatory and anti-microbial properties are disclosed. Pharmaceutical compositions comprising such compounds and methods of treating cancer, inflammatory conditions, and microbial infections with the disclosed compounds or the disclosed pharmaceutical compositions are also disclosed.Type: GrantFiled: April 29, 2005Date of Patent: October 2, 2007Assignee: Nereus Pharmaceuticals, Inc.Inventors: Barbara Christine Potts, Venkat Macherla, Scott Sherman Mitchell, Ram Rao Manam, Katherine Reed, Kin Sing Lam, Saskia Neuteboom, Ta-Hsiang Chao, Benjamin Nicholson, Cheryl Billstrom
-
Patent number: 7112581Abstract: Compounds represented by the following structure (I), acid-addition salts and pro-drugs are disclosed: wherein the ring structure includes no substitutions, one substitution, or more than one substitution; and wherein n is equal to an integer grater than 1, preferably 2, 3, or 4; m is equal to a positive integer, preferably 1, 2 or 3, and each separate Xn and X are each separately selected from a nucleophilic residue, preferably —H, —OH, —O—CO-alkyl, —O-alkyl, —NH2, a halogen and the like; and wherein the dashed line represents a C—C bond or a C—H bond, and the dashed and solid line represents either a carbon-carbon single bond or a carbon-carbon double bond.Type: GrantFiled: September 25, 2003Date of Patent: September 26, 2006Assignee: Nereus Pharmaceuticals, Inc.Inventors: Scott C. Mitchell, Benjamin Nicholson
-
Publication number: 20060205799Abstract: Disclosed herein are various novel oxazolidinone, imidazolidinone, and thiazolidinone analogs and methods of treating cancer and/or microbial infection using these analogs. Particular 4-oxazolidinone compounds are shown to have anti-cancer and anti-microbial activity.Type: ApplicationFiled: February 21, 2006Publication date: September 14, 2006Inventors: Venkata Macherla, Benjamin Nicholson, Kin Lam
-
Publication number: 20050288352Abstract: Compounds of Formulae I-VI and derivatives thereof having anti-cancer, anti-inflammatory, and anti-microbial properties and to compositions that include one or more of compounds and their derivatives or analogs having anti-cancer, anti-inflammatory and anti-microbial properties are disclosed. Pharmaceutical compositions comprising such compounds and methods of treating cancer, inflammatory conditions, and microbial infections with the disclosed compounds or the disclosed pharmaceutical compositions are also disclosed.Type: ApplicationFiled: April 29, 2005Publication date: December 29, 2005Inventors: Barbara Potts, Venkat Macherla, Scott Mitchell, Ram Manam, Katherine Reed, Kin Lam, Saskia Neuteboom, Ta-Hsiang Chao, Benjamin Nicholson, Cheryl Billstrom
-
Publication number: 20050197344Abstract: Compounds represented by the following structure (I) are disclosed: as are methods for making such compounds, wherein said methods comprise reacting a diacyldiketopiperazine with a first aldehyde to produce an intermediate compound; and reacting the intermediate compound with a second aldehyde to produce the class of compounds with the generic structure, where the first aldehyde and the second aldehydes are selected from the group consisting of an oxazolecarboxaldeyhyde, imidazolecarboxaldehyde, a benzaldehyde, imidazolecarboxaldehyde derivatives, and benzaldehyde derivatives, thereby forming the above compound wherein R1, R1?, R1?, R2, R3, R4, R5, and R6, X1 and X2, Y, Z, Z1, Z2, Z3, and Z4 may each be separately defined in a manner consistent with the accompanying description. Compositions and methods for treating vascular proliferation are also disclosed.Type: ApplicationFiled: February 4, 2005Publication date: September 8, 2005Inventors: Michael Palladino, George Lloyd, Yoshio Hayashi, Benjamin Nicholson
-
Publication number: 20040132997Abstract: Compounds represented by the following structure (I), acid-addition salts and prodrugs are disclosed: 1Type: ApplicationFiled: September 25, 2003Publication date: July 8, 2004Inventors: Scott C. Mitchell, Benjamin Nicholson