Patents by Inventor Benjamin P. Bowen

Benjamin P. Bowen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11948662
    Abstract: Disclosed herein are systems and methods for associating metabolites with genes. In some embodiments, after potential metabolites are identified based on spectroscopy data of the content of an organism, possible reactions capable of producing the potential metabolites are determined. The possible reactions are compared to gene sequences in a database, and an association score for the likelihood that a gene sequence is related to the potential metabolites is calculated.
    Type: Grant
    Filed: February 16, 2018
    Date of Patent: April 2, 2024
    Assignee: The Regents of the University of California
    Inventors: Onur Erbilgin, Benjamin P. Bowen, Trent R. Northen, Markus de Raad, Oliver Ruebel
  • Patent number: 11353467
    Abstract: Disclosed herein are methods for identifying one or more diseased cells in a subject. Some embodiments include providing a biological sample derived from a subject, analyzing the biological sample by mass spectrometry, and determining the abundance of one or more lipids in the biological sample, wherein an altered abundance of the one or more lipids in the biological sample, as compared to a reference level, indicates a presence of one or more diseased cells in the subject from which the biological sample is derived.
    Type: Grant
    Filed: January 23, 2014
    Date of Patent: June 7, 2022
    Assignee: The Regents of the University of California
    Inventors: Katherine B. Louie, Benjamin P. Bowen, Trent R. Northen
  • Patent number: 10860526
    Abstract: Disclosed are systems and software that provide a high-performance, extensible file format and web API for remote data access and a visual interface for data viewing, query, and analysis. The described system can support storage of raw spectroscopic data such as neural recording data, MSI data, metadata, and derived analyses in a single, self-describing format that may be compatible by a large range of analysis software.
    Type: Grant
    Filed: November 27, 2013
    Date of Patent: December 8, 2020
    Assignee: The Regents of the University of California
    Inventors: Benjamin P. Bowen, Oliver Ruebel
  • Patent number: 10386371
    Abstract: Provided herein are methods for measuring molecular flux rates of molecules of interest in a tissue sample in spatially-organized manner and generating output (e.g., an image, a heat map, a contour map, a table or a database) representing the molecular flux rates of each spatially-defined location of the sample. Provided herein are also the output, as well as systems and computer-readable medium with computer-executable instructions for determining molecular flux rates of molecules of interest in the sample.
    Type: Grant
    Filed: September 7, 2012
    Date of Patent: August 20, 2019
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Benjamin P. Bowen, Katherine B. Louie, Trent R. Northen, Marc K. Hellerstein
  • Publication number: 20180239863
    Abstract: Disclosed herein are systems and methods for associating metabolites with genes. In some embodiments, after potential metabolites are identified based on spectroscopy data of the content of an organism, possible reactions capable of producing the potential metabolites are determined. The possible reactions are compared to gene sequences in a database, and an association score for the likelihood that a gene sequence is related to the potential metabolites is calculated.
    Type: Application
    Filed: February 16, 2018
    Publication date: August 23, 2018
    Inventors: Onur Erbilgin, Benjamin P. Bowen, Trent R. Northen, Markus de Raad, Oliver Ruebel
  • Publication number: 20170030935
    Abstract: Disclosed herein are methods for identifying one or more diseased cells in a subject, methods for cancer diagnosis, methods for determining cancer progression in a subject and methods for assessing health status in a subject.
    Type: Application
    Filed: January 23, 2014
    Publication date: February 2, 2017
    Inventors: Katherine B. LOUIE, Benjamin P. BOWEN, Trent R. NORTHEN
  • Publication number: 20160003855
    Abstract: Disclosed herein are methods for identifying one or more diseased cells in a subject, methods for cancer diagnosis, methods for determining cancer progression in a subject and methods for assessing health status in a subject.
    Type: Application
    Filed: January 23, 2013
    Publication date: January 7, 2016
    Inventors: Katherine B. LOUIE, Benjamin P. BOWEN, Trent R. NORTHEN
  • Publication number: 20140329274
    Abstract: Provided herein are methods for measuring molecular flux rates of molecules of interest in a tissue sample in spatially-organized manner and generating output (e.g., an image, a heat map, a contour map, a table or a database) representing the molecular flux rates of each spatially-defined location of the sample. Provided herein are also the output, as well as systems and computer-readable medium with computer-executable instructions for determining molecular flux rates of molecules of interest in the sample.
    Type: Application
    Filed: September 7, 2012
    Publication date: November 6, 2014
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Benjamin P. Bowen, Katherine B. Louie, Trent R. Northen, Marc K. Hellerstein
  • Publication number: 20140164444
    Abstract: Disclosed are systems and software that provide a high-performance, extensible file format and web API for remote data access and a visual interface for data viewing, query, and analysis. The described system supports can support storage of raw spectroscopic data such as neural recording data, MSI data, metadata, and derived analyses in a single, self-describing format that may be compatible by a large range of analysis software.
    Type: Application
    Filed: November 27, 2013
    Publication date: June 12, 2014
    Applicant: The Regents of the University of California
    Inventors: Benjamin P. Bowen, Oliver Ruebel
  • Patent number: 7193706
    Abstract: This invention provides a method for screening large numbers of individual cells or colonies of cells using scanning microscopy coupled with fluorescence lifetime measurement and analysis, using time-correlated single photon counting. This invention further provides an automated method for selecting cells that exhibit desired characteristics. The method uses the scanning microscope system to focus a laser beam onto a surface upon which cells are immobilized on the timescale of the procedure. The cells that are illuminated in this way are killed or their growth is inhibited. The focused laser beam is scanned across the surface and turned on and off during the scanning process such that only non-irradiated cells survive, resulting in a patterned cell growth This invention further provides a computer-controlled projection device, such as a micro-mirror array or a liquid crystal display system, which is sued to project an image onto the cells.
    Type: Grant
    Filed: August 2, 2001
    Date of Patent: March 20, 2007
    Assignee: Arizona Board of Regents, Acting on Behalf of Arizona State University
    Inventors: Neal W. T. Woodbury, Benjamin P. Bowen, Allan Scruggs
  • Patent number: 7169272
    Abstract: Construction and characterization of microfabricated recessed disk microelectrodes (RDMs) of 14 and 55 ?m diameter are reported. The work reported here makes several new contributions to the current literature on microfabricated RDMs. Hybrid blamers were constructed by fusion of vesicles of dimyristoylphosphatidyl choline (DMPC), which forms the top layer, with ethanol-rinsed SAMs of hexadecanethiol on gold, which form the bottom layer. Gramicidin A was included in the modifying solutions to incorporate it into hybrid blamers.
    Type: Grant
    Filed: March 22, 2002
    Date of Patent: January 30, 2007
    Assignee: Board of Trustees of the University of Arkansas
    Inventors: Ingrid Fritsch, Charles Sherman Henry, Benjamin P. Bowen, Walter Vandaveer, Nicole Bratcher
  • Patent number: 7144486
    Abstract: Microcavities and micropores that are microscopic (<1 mm) in width and depth and contain any number of individually-addressable electrodes, separated by insulators, along the walls of each cavity. The conducting materials, and the insulator materials can be deposited alternately onto a starting substrate, which is typically an oxidized silicon wafer or polyimide film, but may be any substrate that shows good adhesion to the materials layered on it. The cavities are etched through these layers, perpendicular to the plane of the substrate, exposing the layers at their edges. Pores may be carved entirely through the device.
    Type: Grant
    Filed: December 12, 2001
    Date of Patent: December 5, 2006
    Assignee: Board of Trustees of the University of Arkansas
    Inventors: Ingrid Fritsch, Charles Sherman Henry, Benjamin P. Bowen, Walter R. Vandaveer, Nicole Bratcher
  • Publication number: 20030148393
    Abstract: This invention provides a method for screening large numbers of individual cells or colonies of cells using scanning microscopy coupled with fluorescence lifetime measurement and analysis, using time-correlated single photon counting. This invention further provides an automated method for selecting cells that exhibit desired characteristics. The method uses the scanning microscope system to focus a laser beam onto a surface upon which cells are immobilized on the timescale of the procedure. The cells that are illuminated in this way are killed or their growth is inhibited. The focused laser beam is scanned across the surface and turned on and off during the scanning process such that only non-irradiated cells survive, resulting in a patterned cell growth This invention further provides a computer-controlled projection device, such as a micro-mirror array or a liquid crystal display system, which is sued to project an image onto the cells.
    Type: Application
    Filed: January 28, 2003
    Publication date: August 7, 2003
    Inventors: Neal W.T. Woodbury, Benjamin P Bowen, Allan Scruggs
  • Publication number: 20030015422
    Abstract: Construction and characterization of microfabricated recessed disk microelectrodes (RDMs) of 14 and 55 &mgr;m diameter are reported. The work reported here makes several new contributions to the current literature on microfabricated RDMs. Hybrid blamers were constructed by fusion of vesicles of dimyristoylphosphatidyl choline (DMPC), which forms the top layer, with ethanol-rinsed SAMs of hexadecanethiol on gold, which form the bottom layer. Gramicidin A was included in the modifying solutions to incorporate it into hybrid blamers.
    Type: Application
    Filed: March 22, 2002
    Publication date: January 23, 2003
    Inventors: Ingrid Fritsch, Charles Sherman Henry, Benjamin P. Bowen, Walter Vandaveer, Nicole Bratcher