Patents by Inventor Benjamin P. Warner

Benjamin P. Warner has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 12214564
    Abstract: An optical assembly (200) including an encapsulated multilayer optical film (250). Methods of making and using such optical assemblies also are disclosed.
    Type: Grant
    Filed: December 1, 2020
    Date of Patent: February 4, 2025
    Assignee: 3M Innovative Properties Company
    Inventors: Gregg A. Ambur, Douglas S. Dunn, Henry A. Kostalik, IV, Christopher S. DeGraw, Thomas P. Klun, Benjamin R. Coonce, Richard J. Pokorny, Chunjie Zhang, Laurent Froissard, Joseph S. Warner
  • Patent number: 11639941
    Abstract: The present invention includes a method and apparatus for measuring the transport of analytes from living, biological cells through a cell barrier, which includes, but is not limited to, steps of providing the living, biological cells loaded with analytes, unloading at least a portion of said analytes from the cells through ion channels, removing unloaded analyte remaining in the cells, and measuring the analytes using x-ray fluorescence, specifically wherein the measurement uses an energy dispersive x-ray fluorescence spectrometer equipped with a microfocus x-ray tube. These steps may be repeated so that multiple measurements can be obtained over a period of time.
    Type: Grant
    Filed: August 22, 2018
    Date of Patent: May 2, 2023
    Assignee: Icagen, LLC
    Inventors: Benjamin P. Warner, Lori J. Peterson, Jennifer A. Berger, Eva R. Birnbaum, Rebecca L. E. Miller
  • Patent number: 11598759
    Abstract: Methods, apparatus and compositions are described for the measurement of metal and/or metalloid elements, including selenium in samples. More specifically, the present disclosure provides a sensor and/or array of sensors to measure metal and/or metalloid analytes, e.g., sensor and/or array of sensors having a chelator molecule, the chelator molecule including a peptide.
    Type: Grant
    Filed: November 26, 2019
    Date of Patent: March 7, 2023
    Assignee: Icagen, LLC
    Inventors: Benjamin P. Warner, Chang-Tai Hsieh, Emilia Solomon, Lori Peterson, Douglas Krafte, Nathan Zahler
  • Patent number: 11561188
    Abstract: The present invention includes a method for analyzing reactions. The method includes the steps of providing a solution of at least one acceptor chemical and at least one donor chemical. The donor chemical is capable of donating a chemical moiety to the acceptor chemical. The solution further includes at least one controller chemical that affects the reaction between the donor chemical and the acceptor chemical. The solution is then incubated so that a portion of the acceptor chemical reacts with the donor chemical to form an acceptor product. Unreacted donor chemical is separated from the acceptor product. The acceptor product or the donor chemical is then measured using X-ray fluorescence. Another aspect of the present invention includes a method for analyzing protein function. The method includes the steps of providing a solution of at least one acceptor chemical and at least one donor chemical. The donor chemical is capable of donating a chemical moiety to the acceptor chemical.
    Type: Grant
    Filed: January 23, 2020
    Date of Patent: January 24, 2023
    Assignee: Icagen, LLC
    Inventors: Eva R. Birnbaum, Benjamin P. Warner, Sharon M. Baldwin, Jennifer A. Berger, Lori J. Peterson-Court, Michael N. Harris, Rebecca L. E. Miller
  • Patent number: 10948437
    Abstract: The present invention is a method to quantify biomarkers. The method uses an X-ray florescence spectrometer to perform an X-ray fluorescence analysis on the sample to obtain spectral features derived from the biomarker; and quantifying the X-ray fluorescence signal of the biomarker.
    Type: Grant
    Filed: September 18, 2019
    Date of Patent: March 16, 2021
    Assignee: ICAGEN, LLC
    Inventors: Lori J. Peterson, Camaron A. Mortillaro, Benjamin P. Warner, Nathan H. Zahler, Pratima Bharti, Chang-Tai Hsieh, Emilia A. Solomon
  • Patent number: 10877035
    Abstract: X-ray fluorescence (XRF) spectrometry has been used for detecting binding events and measuring binding selectivities between chemicals and receptors. XRF may also be used for estimating the therapeutic index of a chemical. For estimating the binding selectivities of a chemical versus chemical analogs, for measuring post translational modification of proteins, and for drug manufacturing.
    Type: Grant
    Filed: April 22, 2015
    Date of Patent: December 29, 2020
    Assignee: ICAGEN, LLC
    Inventors: Eva R. Birnbaum, Andrew T. Koppisch, Sharon M. Baldwin, Benjamin P. Warner, T. Mark McCleskey, Jennifer A. Berger, Jeffrey J. Stewart, Michael N. Harris, Anthony K. Burrell
  • Patent number: 10782253
    Abstract: The present invention includes an apparatus for preparing samples for measurement by x-ray fluorescence spectrometry. The apparatus comprises a plate having one or more holes passing through the plate. The holes are covered by a film on one side of the plate. The holes are less than 500 micrometers across in one dimension where the film covers the holes. The film is translucent to x-rays. The present invention also includes an apparatus for preparing samples for measurement by x-ray fluorescence spectrometry. The apparatus comprises a plate having one or more holes passing through the plate. The holes are covered on one side of the plate by a detachable cover forming a water-tight seal against the plate. The cover is substantially free of the elements osmium, yttrium, iridium, phosphorus, zirconium, platinum, gold, niobium, mercury, thallium, molybdenum, sulfur, lead, bismuth, technetium, ruthenium, chlorine, rhodium, palladium, argon, silver, and thorium.
    Type: Grant
    Filed: September 23, 2016
    Date of Patent: September 22, 2020
    Assignee: Icagen, LLC
    Inventors: Eva R. Birnbaum, Benjamin P. Warner, Sharon M. Baldwin, Jennifer A. Berger, Rebecca L. E. Miller
  • Publication number: 20200157598
    Abstract: The present invention includes a method for analyzing reactions. The method includes the steps of providing a solution of at least one acceptor chemical and at least one donor chemical. The donor chemical is capable of donating a chemical moiety to the acceptor chemical. The solution further includes at least one controller chemical that affects the reaction between the donor chemical and the acceptor chemical. The solution is then incubated so that a portion of the acceptor chemical reacts with the donor chemical to form an acceptor product. Unreacted donor chemical is separated from the acceptor product. The acceptor product or the donor chemical is then measured using X-ray fluorescence. Another aspect of the present invention includes a method for analyzing protein function. The method includes the steps of providing a solution of at least one acceptor chemical and at least one donor chemical. The donor chemical is capable of donating a chemical moiety to the acceptor chemical.
    Type: Application
    Filed: January 23, 2020
    Publication date: May 21, 2020
    Inventors: Eva R. BIRNBAUM, Benjamin P. WARNER, Sharon M. BALDWIN, Jennifer A. BERGER, Lori J. PETERSON-COURT, Michael N. HARRIS, Rebecca L.E. MILLER
  • Publication number: 20200088707
    Abstract: Methods, apparatus and compositions are described for the measurement of metal and/or metalloid elements, including selenium in samples.
    Type: Application
    Filed: November 26, 2019
    Publication date: March 19, 2020
    Inventors: Benjamin P. WARNER, Chang-Tai HSIEH, Emilia SOLOMON, Lori PETERSON, Douglas KRAFTE, Nathan ZAHLER
  • Patent number: 10577642
    Abstract: The present invention includes a method for analyzing reactions. The method includes the steps of providing a solution of at least one acceptor chemical and at least one donor chemical. The donor chemical is capable of donating a chemical moiety to the acceptor chemical. The solution further includes at least one controller chemical that affects the reaction between the donor chemical and the acceptor chemical. The solution is then incubated so that a portion of the acceptor chemical reacts with the donor chemical to form an acceptor product. Unreacted donor chemical is separated from the acceptor product. The acceptor product or the donor chemical is then measured using X-ray fluorescence. Another aspect of the present invention includes a method for analyzing protein function. The method includes the steps of providing a solution of at least one acceptor chemical and at least one donor chemical. The donor chemical is capable of donating a chemical moiety to the acceptor chemical.
    Type: Grant
    Filed: April 24, 2018
    Date of Patent: March 3, 2020
    Assignee: Icagen, Inc.
    Inventors: Eva R. Birnbaum, Benjamin P. Warner, Sharon M. Baldwin, Jennifer A. Berger, Lori J. Peterson-Court, Michael N. Harris, Rebecca L. E. Miller
  • Publication number: 20200011815
    Abstract: The present invention is a method to quantify biomarkers. The method uses an X-ray florescence spectrometer to perform an X-ray fluorescence analysis on the sample to obtain spectral features derived from the biomarker; and quantifying the X-ray fluorescence signal of the biomarker.
    Type: Application
    Filed: September 18, 2019
    Publication date: January 9, 2020
    Inventors: Lori J. PETERSON, Camaron A. MORTILLARO, Benjamin P. WARNER, Nathan H. ZAHLER, Pratima BHARTI, Chang-Tai HSIEH, Emilia A. SOLOMON
  • Patent number: 10527600
    Abstract: Methods, apparatus and compositions are described for the measurement of metal and/or metalloid elements, including selenium in samples. More specifically, the invention provides a sensor and/or array of sensors to measure metal and/or metalloid analytes, e.g. sensor and/or array of sensors having a chelator molecule, the chelator molecule including a peptide which has a phenylalanine derivative.
    Type: Grant
    Filed: April 18, 2017
    Date of Patent: January 7, 2020
    Assignee: Icagen, Inc.
    Inventors: Benjamin P. Warner, Chang-Tai Hsieh, Emilia Solomon, Lori Peterson, Douglas Krafte, Nathan Zahler
  • Patent number: 10458933
    Abstract: The present invention is a method to quantify biomarkers. The method uses an X-ray fluorescence spectrometer to perform an X-ray fluorescence analysis on the sample to obtain spectral features derived from the biomarker; and quantifying the X-ray fluorescence signal of the biomarker.
    Type: Grant
    Filed: August 22, 2018
    Date of Patent: October 29, 2019
    Assignee: Icagen, Inc.
    Inventors: Lori J. Peterson, Cameron A. Mortillaro, Benjamin P. Warner, Nathan H. Zahler, Pratima Bharti, Chang-Tai Hsieh, Emilia A. Solomon
  • Publication number: 20190120807
    Abstract: Methods, apparatus and compositions are described for the measurement of metal and/or metalloid elements, including selenium in samples.
    Type: Application
    Filed: April 18, 2017
    Publication date: April 25, 2019
    Inventors: Benjamin P. WARNER, Chang-Tai HSIEH, Emilia SOLOMON, Lori PETERSON, Douglas KRAFTE, Nathan ZAHLER
  • Publication number: 20190064182
    Abstract: The present invention includes a method and apparatus for measuring the transport of analytes through a cell barrier.
    Type: Application
    Filed: August 22, 2018
    Publication date: February 28, 2019
    Applicant: ICAGEN, INC.
    Inventors: Benjamin P. Warner, Lori J. Peterson, Jennifer A. Berger, Eva R. Birnbaum, Rebecca L.E. Miller
  • Publication number: 20190011382
    Abstract: The present invention is a method to quantify biomarkers. The method uses an X-ray fluorescence spectrometer to perform an X-ray fluorescence analysis on the sample to obtain spectral features derived from the biomarker; and quantifying the X-ray fluorescence signal of the biomarker.
    Type: Application
    Filed: August 22, 2018
    Publication date: January 10, 2019
    Applicant: ICAGEN, INC.
    Inventors: Lori J. Peterson, Cameron A. Mortillaro, Benjamin P. Warner, Nathan H. Zahler, Pratima Bharti, Chang-Tai Hsieh, Emilia A. Solomon
  • Patent number: 10082511
    Abstract: The present invention includes a method and apparatus for measuring the transport of analytes from living, biological cells through a cell barrier, which includes, but is not limited to, steps of providing the living, biological cells loaded with analytes, unloading at least a portion of said analytes from the cells through ion channels, removing unloaded analyte remaining in the cells, and measuring the analytes using x-ray fluorescence, specifically wherein the measurement uses an energy dispersive x-ray fluorescence spectrometer equipped with a microfocus x-ray tube. These steps may be repeated so that multiple measurements can be obtained over a period of time.
    Type: Grant
    Filed: October 26, 2016
    Date of Patent: September 25, 2018
    Assignee: ICAGEN, INC.
    Inventors: Benjamin P. Warner, Lori J. Peterson, Jennifer A. Berger, Eva R. Birnbaum, Rebecca L. E. Miller
  • Patent number: 10082474
    Abstract: The present invention is a method to quantify biomarkers. The method uses an X-ray fluorescence spectrometer to perform an X-ray fluorescence analysis on the sample to obtain spectral features derived from the biomarker; and quantifying the X-ray fluorescence signal of the biomarker.
    Type: Grant
    Filed: August 3, 2016
    Date of Patent: September 25, 2018
    Assignee: ICAGEN, INC.
    Inventors: Lori J. Peterson, Cameron A. Mortillaro, Benjamin P. Warner, Nathan H. Zahler, Pratima Bharti, Chang-Tai Hsieh, Emilia A. Solomon
  • Publication number: 20180237823
    Abstract: The present invention includes a method for analyzing reactions. The method includes the steps of providing a solution of at least one acceptor chemical and at least one donor chemical. The donor chemical is capable of donating a chemical moiety to the acceptor chemical. The solution further includes at least one controller chemical that affects the reaction between the donor chemical and the acceptor chemical. The solution is then incubated so that a portion of the acceptor chemical reacts with the donor chemical to form an acceptor product. Unreacted donor chemical is separated from the acceptor product. The acceptor product or the donor chemical is then measured using X-ray fluorescence. Another aspect of the present invention includes a method for analyzing protein function. The method includes the steps of providing a solution of at least one acceptor chemical and at least one donor chemical. The donor chemical is capable of donating a chemical moiety to the acceptor chemical.
    Type: Application
    Filed: April 24, 2018
    Publication date: August 23, 2018
    Inventors: Eva R. Birnbaum, Benjamin P. Warner, Sharon M. Baldwin, Jennifer A. Berger, Lori J. Peterson-Court, Michael N. Harris, Rebecca L.E. Miller
  • Publication number: 20180141277
    Abstract: Methods and apparatus are described for depositing materials at a precise location. The deposition is accomplished by using CNC control and a nozzle guide.
    Type: Application
    Filed: September 17, 2017
    Publication date: May 24, 2018
    Inventors: Benjamin P. Warner, Francesco de Rege Thesauro