Abstract: Disclosed herein are new compounds, pharmaceutical composition thereof and to their use for the treatment and/or prophylaxis of disorders or conditions related to Nicotinamide adenine dinucleotide phosphate oxidase (NADPH Oxidase).

Abstract: The present invention is related to compounds, methods, compositions and uses that are able to inhibit mitochondrial pyruvate carrier (MPC) activity and which are useful for immunotherapy, in particular T-cell therapies, immune check point inhibitors or anti-cancer vaccine.

Abstract: Disclosed herein are new compounds, pharmaceutical composition thereof and to their use for the treatment and/or prophylaxis of disorders or conditions related to Nicotinamide adenine dinucleotide phosphate oxidase (NADPH Oxidase).

Abstract: The present invention concerns 2,6-quinolinyl derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals.

Abstract: A system, a user interface and computer-readable media for associating metadata with digital media. Tags are associated with single-action user inputs. Entry of one of the single-action user inputs is detected. The tag associated with the detected input is stored as metadata associated with a selected item of digital media.

Abstract: A method to expose status information is provided. The status information is associated with metadata extracted from multimedia files and stored in a metadata database. The metadata information that is extracted from the multimedia files is stored in a read queue to allow a background thread to process the metadata and populate the metadata database. Additionally, the metadata database may be updated to include user-define metadata, which is written back to the multimedia files. The user-defined metadata is included in a write queue and is written to the multimedia files associated with the user-defined metadata. The status of the read and write queues are exposed to a user through a graphical user interface. The status may include the list of multimedia files included in the read and write queues, the priorities of each multimedia file, and the number of remaining multimedia files.

Abstract: The present invention concerns 2,6-quinolinyl derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals.

Abstract: Methods and systems that permit a user to associate metadata representing one or more workflow-related actions with an image file are provided. Workflow-related actions describe one or more actions which may be undertaken with respect to the associated image file. For instance, workflow-related actions may include, by way of example only, printing, editing, reviewing, sharing, deleting, and the like. Once associated with metadata representing one or more workflow-related actions, the image file may be retrieved based upon a query for at least one of the workflow-related actions. If more than one workflow-related action is represented in the metadata associated with the image file, the image file may be retrieved based upon a query for each workflow-related action individually or multiple workflow-related actions concurrently.

Abstract: A method, system and article of manufacture suitable for rendering a graphical user interface including at least one viewable graphical element, the graphical element having a filename associated therewith, the filename being absent from the user interface.

Abstract: Systems and methods for digital negatives are described. In one aspect, a digital negative is created on a computing device from a digital image. The digital image is linked to the digital negative. In response to a save operation associated with the digital image, a new digital image is generated and bi-directionally connected to the digital negative. In response to a revert operation associated with the new digital image, contents of the new digital image are replaced with contents of the digital negative.