Patents by Inventor Benjamin Pomerantz

Benjamin Pomerantz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Nucleic acids, polypeptides, and methods for modulating apoptosis
    Patent number: 7217517
    Abstract: The present invention provides methods of identifying an incidence of ischemia in mammalian tissue, particularly mammalian heart tissue. Further, a method of reducing apoptosis in mammalian tissue, preferably heart tissue, is provided. These methods involve measuring and comparing the gene expression levels of both apoptosis-specific eIF-5A and proliferating eIF-5A and correlating an incidence of ischemia when the expression level of apoptosis-specific eIF-5a is higher than proliferating eIF-5A. In the method of reducing apoptosis in mammalian tissue, there is provided an agent that inhibits expression of apoptosis-specific eIF-5A. Preferred agents are antisense oligonucleotides to human apoptosis-specific eIF-5A.
    Type: Grant
    Filed: October 23, 2002
    Date of Patent: May 15, 2007
    Assignee: Senesco Technologies, Inc.
    Inventors: John E. Thompson, Catherine Taylor, Dominic Cliche, Charles Dinarello, Leonid Reznikov, Benjamin Pomerantz
  • Use of IL-18 inhibitors for the treatment and/or prevention of heart disease
    Publication number: 20040234523
    Abstract: The invention relates to the use of an inhibitor of IL-18 in the preparation of a medicament for treatment and/or prevention of a heart disease, in particular ischemic heart disease. Combinations of an IL-18 inhibitor and/or a TNF antagonist are also considered for the treatment and/or prevention of a heart disease.
    Type: Application
    Filed: February 6, 2004
    Publication date: November 25, 2004
    Inventors: Charles Dinarello, Benjamin Pomerantz, Leonid Reznikov, Alden Harken, Yolande Chvatchko
  • Nucleic acids, polypeptides, and methods for modulating apoptosis
    Publication number: 20030144238
    Abstract: The present invention provides methods of identifying an incidence of ischemia in mammalian tissue, particularly mammalian heart tissue. Further, a method of reducing apoptosis in mammalian tissue, preferably heat tissue, is provided. These methods involve measuring and comparing the gene expression levels of both apoptosis-specific eIF-5A and proliferating eIF-5A and correlating an incidence of ischemia when the expression level of apoptosis-specific eIF-5a is higher than proliferating eIF-5A. In the method of reducing apoptosis in mammalian tissue, there is provided an agent that inhibits expression of apoptosis-specific eIF-5A. Preferred agents are antisense oligonucleotides to human apoptosis-specific eIF-5A.
    Type: Application
    Filed: October 23, 2002
    Publication date: July 31, 2003
    Inventors: John E. Thompson, Catherine Taylor, Dominic Cliche, Charles Dinarello, Leonid Reznikov, Benjamin Pomerantz