Abstract: Substituted cyclohexyl chemical entities of Formula (I): wherein Ra, G, and Rb have any of the values described herein, and compositions comprising such chemical entities; methods of making them; and their use in a wide range of methods, including metabolic and reaction kinetic studies; detection and imaging techniques; radioactive therapies; modulating and treating disorders mediated by nociceptin activity or dopamine signaling; treating neurological disorders, neurodegenerative diseases, depression, and schizophrenia; enhancing the efficiency of cognitive and motor training; and treating peripheral disorders, including renal, respiratory, gastrointestinal, liver, genitourinary, metabolic, and inflammatory disorders.

Abstract: Systems and methods for treating a plurality of tissue sites include a multi-port therapy unit. The multi-port therapy unit includes a plurality of patient-side ports each fluidly coupled to a plurality of conduits and a fluid reservoir fluidly coupled to the plurality of ports. A plurality of pressure sensors are associated with the plurality of patient-side ports to determining a pressure associated with each conduit. A controller is operatively coupled to the plurality of pressure sensors to receive treatment pressure data, monitor pressure for each pressure sensor of the plurality of pressure sensors, and signal an alarm condition if the pressure is outside of a pre-selected range. The system includes a reduced-pressure source fluidly coupled to a dressing at each tissue site through the multi-port therapy unit.

Abstract: A tubeset module includes one or more elements of a negative pressure wound therapy (“NPWT”) system, such as a valve, a calibrated leak, a pressure sensor, etc. The tubeset module may communicate with a controller of the NPWT system via a communications interface provided by the tubeset module. The communication between the tubeset module and the controller may be used to fully automate one or more processes involving the operation of the components of the NPWT system included in the tubeset module, allowing the NPWT system to, e.g. estimate a wound site volume, estimate a volume of fluid to be instilled, monitor wound healing progression, etc. without requiring any user interaction or involvement. The tubeset module may be defined by one or more housing elements. The tubeset module may be incorporated into any of the tubing, fluid canister, wound dressing and/or therapy device housing components of the NPWT system.

Abstract: A combined instillation fluid delivery pump head and wound fluid collection canister apparatus for use with a negative pressure wound therapy (NPWT) unit includes a body defining a wound fluid collection canister configured to collect wound exudate and defining a pump head formed by a partially cylindrical recess in a wall of the body. The apparatus includes a flexible fluid instillation conduit extending along the pump head to be compressed by a pump rotor from the NPWT unit. The apparatus includes a first conduit fluidly coupled on one end of the first conduit to a negative pressure source on the NPWT unit. The apparatus includes a second conduit having one end of the second conduit communicating with the wound fluid collection canister. The apparatus includes a third conduit fluidly coupled to one end of the flexible fluid instillation conduit.

Abstract: An apparatus for managing fluid from a tissue site may include a first layer and a second layer. The first layer may comprise a first end, a second end, a first surface, a thickness between the first surface and the second surface, a first fluid pathway disposed in the first surface, and a second fluid pathway disposed in the first surface. The first fluid pathway and the second fluid pathway can extend from the first end to the second end. The second layer may have a first end, a second end, a first surface, and a second surface. The second surface of the second layer can be coupled to the first surface of the first layer.

Abstract: A treatment system for applying negative pressure therapy and fluid instillation treatment to a tissue site, particularly an abdominal tissue site, is disclosed. In some embodiments, the treatment system may include a dressing member, a plurality of fluid removal pathways, a fluid instillation matrix, a drape, a negative-pressure source, and a fluid instillation source. Instillation fluid may be delivered from the fluid instillation source to the tissue site through the fluid instillation matrix, and negative pressure may be communicated and fluid withdrawn from the tissue site through the plurality of fluid removal pathways.

Abstract: In some examples, provided is a fluid blockage device for use with a reduced-pressure source for treating a tissue site with reduced pressure. The fluid blockage device may be configured to preclude fluid communication through a port fluidly coupled to the reduced-pressure source when the fluid blockage device contacts a liquid. Other devices, systems, and methods are disclosed.

Abstract: An apparatus for distributing force across a tissue site including a film layer and an embossed layer. The film layer may include a first end and a second end, an aperture near the first end, and a notch extending from the second end to the aperture. The embossed layer may be coupled to the film layer near a periphery of the film layer to define an interior space.

Abstract: A tubeset module includes one or more elements of a negative pressure wound therapy (“NPWT”) system, such as a valve, a calibrated leak, a pressure sensor, etc. The tubeset module may communicate with a controller of the NPWT system via a communications interface provided by the tubeset module. The communication between the tubeset module and the controller may be used to fully automate one or more processes involving the operation of the components of the NPWT system included in the tubeset module, allowing the NPWT system to, e.g. estimate a wound site volume, estimate a volume of fluid to be instilled, monitor wound healing progression, etc. without requiring any user interaction or involvement. The tubeset module may be defined by one or more housing elements. The tubeset module may be incorporated into any of the tubing, fluid canister, wound dressing and/or therapy device housing components of the NPWT system.

Abstract: A process is provided for making a WEE1 inhibitor of the formula (1A) useful in the treatment of conditions characterized by excessive cellular proliferation, such as cancer. In some embodiments, processes are provided for making intermediate compounds of the formulae (3), (5) and (6) as defined herein.

Abstract: Substituted cyclohexyl chemical entities of Formula (I): wherein Ra, G, and Rb have any of the values described herein, and compositions comprising such chemical entities; methods of making them; and their use in a wide range of methods, including metabolic and reaction kinetic studies; detection and imaging techniques; radioactive therapies; modulating and treating disorders mediated by nociceptin activity or dopamine signaling; treating neurological disorders, neurodegenerative diseases, depression, and schizophrenia; enhancing the efficiency of cognitive and motor training; and treating peripheral disorders, including renal, respiratory, gastrointestinal, liver, genitourinary, metabolic, and inflammatory disorders.

Abstract: A wound therapy system includes a therapy unit, a wound dressing and an optional controller. The therapy unit is configured to deliver instillation fluid to a wound site. The wound dressing is formed from a plurality of discrete, individual blocks that are selectively separable from one another along a plurality of separation-lines, allowing the wound dressing to be customized to the shape and size of the wound site. By calculating the remaining blocks that define the wound dressing following customization, the volume of the wound dressing may be determined. The controller may be configured to deliver fluid to the wound site based on this calculated volume. The controller may also optionally be used to gauge the healing of the wound site over time by monitoring the changes in volume of customized wound dressings as wound dressings are replaced during the course of treatment of the wound site.

Abstract: One implementation of the present disclosure is a method for dynamically controlling an alarm of a negative pressure wound therapy (NPWT) device, according to some embodiments. In some embodiments, the method includes initiating NPWT, comparing an initial pump duty to a threshold value to determine a dressing application quality, monitoring a leakage rate of the NPWT, setting a leak threshold value based on the dressing application quality, determining leakage event occurrences in response to the leakage rate exceeding the leak threshold value at multiple times, adjusting the leak threshold value based on at least one of a number of the leakage events over the time period, a time duration between sequentially occurring leakage events of the leakage events, and the dressing application quality, and causing a user interface device to display a leak alert in response to the leakage rate exceeding the adjusted leak threshold value.

Abstract: One implementation of the present disclosure is a method for dynamically controlling an alarm of a negative pressure wound therapy (NPWT) device, according to some embodiments. In some embodiments, the method includes initiating NPWT, comparing an initial pump duty to a threshold value to determine a dressing application quality, monitoring a leakage rate of the NPWT, setting a leak threshold value based on the dressing application quality, determining leakage event occurrences in response to the leakage rate exceeding the leak threshold value at multiple times, adjusting the leak threshold value based on at least one of a number of the leakage events over the time period, a time duration between sequentially occurring leakage events of the leakage events, and the dressing application quality, and causing a user interface device to display a leak alert in response to the leakage rate exceeding the adjusted leak threshold value.

Abstract: A system for providing instillation fluid to a deep abdominal wound includes an instillation module and a connection structure. The instillation module defines a first surface and a second, abdominal contents-facing surface. The instillation module includes a distribution hub configured to receive instillation fluid from an instillation fluid source. The connection structure includes a first surface, a second, abdominal contents-facing surface; and a flow path extending between the first surface and the second surface. The flow path includes an inlet configured to receive an instillation fluid conduit engaged with the instillation fluid source and an outlet in fluid communication with the instillation module. The flow path defines an axis extending between the inlet and the outlet. The flow path is configured to compress in a direction defined by the axis.

Abstract: A negative pressure wound therapy device, kit, and method are provided for improved treatment of wounds on complex three-dimensional anatomies. The device includes a conformable manifold made of a porous and permeable material with a pattern of cuts designed to transform the manifold from a relaxed, planar state to a pliable three-dimensional state when extended along the lateral axis. The kit further may include a wound interface layer, an adhesive, breathable drape, and a pneumatic connection to a negative pressure wound therapy device. Finally, a method for treating wounds using reduced pressure and the presently disclosed kit is provided.

Abstract: A negative pressure wound therapy system includes at least one sensor coupled to a wound dressing for a wound of a patient, and a processing circuit. The at least one sensor is configured to output a measurement of the pressure in the wound dressing. The processing circuit is configured to open a sealable aperture, receive the pressure measurements in the wound dressing, calculate a rate of pressure decay, correlate the rate of pressure decay in the wound dressing to a wound dressing fluid absorbent capacity and other therapy parameters, and output the wound dressing fluid absorbent capacity and other therapy parameters to a remote electronic device.

Abstract: Substituted cyclohexyl chemical entities of Formula (I): wherein Ra, G, and Rb have any of the values described herein, and compositions comprising such chemical entities; methods of making them; and their use in a wide range of methods, including metabolic and reaction kinetic studies; detection and imaging techniques; radioactive therapies; modulating and treating disorders mediated by nociceptin activity or dopamine signaling; treating neurological disorders, neurodegenerative diseases, depression, and schizophrenia; enhancing the efficiency of cognitive and motor training; and treating peripheral disorders, including renal, respiratory, gastrointestinal, liver, genitourinary, metabolic, and inflammatory disorders.

Abstract: A wound incision model includes an outer frame defining and opening and a simulated tissue disposed at least partially within the opening. The simulated tissue includes a body and a simulated wound. The simulated wound is disposed at least partially within the body. The simulated wound includes an aperture extending through the body from a first surface of the body to a second surface of the body. The simulated wound is configured to deform in response to a negative pressure applied across the simulated wound.

Abstract: A negative pressure wound therapy (NPWT) device includes a canister, a pump, a filter, and a control unit. The canister is configured to collect wound exudate from a wound site. The pump is fluidly coupled to the canister and configured to draw a vacuum within the canister by pumping air out of the canister. The filter is positioned between the canister and the pump such that the air pumped out of the canister passes through the filter in a first direction. The control unit is configured to operate the pump and to purge the filter by causing airflow through the filter in a second direction, opposite the first direction.