Abstract: Apparatuses, systems, and methods for optimizing fluid storage canisters for use in negative pressure therapy systems are described. A fluid storage canister includes a first wall and a second wall coupled to the first wall. The canister has a chamber disposed between the first wall and the second wall. The chamber is configured to be sealed from an ambient environment and to store fluid. A pathway is disposed between the first wall and the second wall. The pathway is configured to be open to the ambient environment. There is a barrier separating the pathway from the chamber. The barrier is configured to permit evaporated fluid in the chamber to transmit through the barrier into the pathway.

Abstract: A wound debridement system includes a wound dressing having an active layer and a wound interface layer. The active layer is formed from one or more drive elements arranged about a film layer, by which the drive elements are attached to the wound interface layer. Activation of the drive elements is configured to cause the movement of the wound interface layer relative to a tissue site to which the wound dressing is applied. The drive elements may include one or more drive members formed of a material having a shape memory effect configured to transition the drive members between expanded and collapsed configurations and/or one or more motors configured to translate or oscillate the active layer. The wound interface layer may be formed having an abrasive wound-facing surface, such that the movement of the wound interface layer causes a mechanical disruption and debridement of debris at the tissue site.

Abstract: A test model may include a chamber, a tissue simulation material, and a visual indicator. The chamber may include a base, a lid, and an interior volume defined between the base and the lid. The tissue simulation material may be disposed within the interior volume of the chamber. The tissue simulation material may include a first surface and a second surface. The tissue simulation material may be configured to deform when the second surface is exposed to a lower pressure than the first surface in the interior volume of the chamber. The visual indicator may be configured to provide a visual state change in response to deformation of the tissue simulation material.

Abstract: An evaporative bridge dressing that may be used with negative-pressure treatment of tissue. The evaporative bridge dressing may have one or more fluid transfer layers comprised of high-density wicking material enclosed between layers of film having high moisture-vapor transfer rates to reduce liquid storage and minimize pressure drop.

Abstract: In some embodiments, a dressing assembly may include a dressing bolster, an interface seal, and a base layer. The dressing bolster may include a first side, a second side, and a periphery. The interface seal may be coupled at the periphery of the dressing bolster. The base layer may include a base layer flange configured to be coupled to the dressing and to extend beyond the periphery of the dressing bolster. The dressing assembly may be suitable for treating a tissue site with reduced pressure and for creating an apposition force between a first portion of the tissue site and a second portion of the tissue site. Other systems, apparatus, and methods are disclosed.

Abstract: A negative pressure wound therapy (NPWT) system includes a therapy unit (102), a first pump (112), a piezo-electric pump (116), and a controller (202). The first pump (112) is configured to draw a negative pressure at a wound site (105) through a first tubular member (122). The piezo-electric pump (116) is fluidly coupled with the first tubular member (122) through a bypass tubular member (124) and is configured to detect a fluid indication. The controller (202) includes processing circuitry configured to obtain feedback signals from the piezo-electric pump (116) and determine if fluid is present at the piezo-electric pump (116) based on the feedback signals.

Abstract: A wound debridement system includes a wound dressing having an active layer and a wound interface layer. The active layer is formed from one or more drive elements arranged about a film layer, by which the drive elements are attached to the wound interface layer. Activation of the drive elements is configured to cause the movement of the wound interface layer relative to a tissue site to which the wound dressing is applied. The drive elements may include one or more drive members formed of a material having a shape memory effect configured to transition the drive members between expanded and collapsed configurations and/or one or more motors configured to translate or oscillate the active layer. The wound interface layer may be formed having an abrasive wound-facing surface, such that the movement of the wound interface layer causes a mechanical disruption and debridement of debris at the tissue site.

Abstract: A canister for use with a wound therapy system includes first and second compartments configured to receive and contain wound exudate, and an airflow pathway. The airflow pathway includes a planar region positioned between the first compartment and the second compartment, an inlet extending from a first end of the planar region at an obtuse angle relative to the planar region, an outlet at a second end of the planar region.

Abstract: In some examples, provided is a fluid blockage device for use with a reduced-pressure source for treating a tissue site with reduced pressure. The fluid blockage device may be configured to preclude fluid communication through a port fluidly coupled to the reduced-pressure source when the fluid blockage device contacts a liquid. Other devices, systems, and methods are disclosed.

Abstract: A wound dressing includes an inelastic absorbent layer, an elastic film, and a plurality of welds. The inelastic absorbent layer is configured to absorb wound fluid and has a first side and a second, wound-facing side. The elastic film is configured to elastically stretch when a stretching force is applied to the wound dressing and elastically recover when the stretching force is removed. The plurality of welds fix the elastic film to the first side of the inelastic absorbent layer such that the elastic film and the inelastic absorbent layer elastically stretch and elastically recover as a unit.

Abstract: Substituted cyclohexyl chemical entities of Formula (I): wherein Ra, G, and Rb have any of the values described herein, and compositions comprising such chemical entities; methods of making them; and their use in a wide range of methods, including metabolic and reaction kinetic studies; detection and imaging techniques; radioactive therapies; modulating and treating disorders mediated by nociceptin activity or dopamine signaling; treating neurological disorders, neurodegenerative diseases, depression, and schizophrenia; enhancing the efficiency of cognitive and motor training; and treating peripheral disorders, including renal, respiratory, gastrointestinal, liver, genitourinary, metabolic, and inflammatory disorders.

Abstract: Systems and methods for treating a plurality of tissue sites include a multi-port therapy unit. The multi-port therapy unit includes a plurality of patient-side ports each fluidly coupled to a plurality of conduits and a fluid reservoir fluidly coupled to the plurality of ports. A plurality of pressure sensors are associated with the plurality of patient-side ports to determining a pressure associated with each conduit. A controller is operatively coupled to the plurality of pressure sensors to receive treatment pressure data, monitor pressure for each pressure sensor of the plurality of pressure sensors, and signal an alarm condition if the pressure is outside of a pre-selected range. The system includes a reduced-pressure source fluidly coupled to a dressing at each tissue site through the multi-port therapy unit.

Abstract: A tubeset module includes one or more elements of a negative pressure wound therapy (“NPWT”) system, such as a valve, a calibrated leak, a pressure sensor, etc. The tubeset module may communicate with a controller of the NPWT system via a communications interface provided by the tubeset module. The communication between the tubeset module and the controller may be used to fully automate one or more processes involving the operation of the components of the NPWT system included in the tubeset module, allowing the NPWT system to, e.g. estimate a wound site volume, estimate a volume of fluid to be instilled, monitor wound healing progression, etc. without requiring any user interaction or involvement. The tubeset module may be defined by one or more housing elements. The tubeset module may be incorporated into any of the tubing, fluid canister, wound dressing and/or therapy device housing components of the NPWT system.

Abstract: A combined instillation fluid delivery pump head and wound fluid collection canister apparatus for use with a negative pressure wound therapy (NPWT) unit includes a body defining a wound fluid collection canister configured to collect wound exudate and defining a pump head formed by a partially cylindrical recess in a wall of the body. The apparatus includes a flexible fluid instillation conduit extending along the pump head to be compressed by a pump rotor from the NPWT unit. The apparatus includes a first conduit fluidly coupled on one end of the first conduit to a negative pressure source on the NPWT unit. The apparatus includes a second conduit having one end of the second conduit communicating with the wound fluid collection canister. The apparatus includes a third conduit fluidly coupled to one end of the flexible fluid instillation conduit.

Abstract: An apparatus for managing fluid from a tissue site may include a first layer and a second layer. The first layer may comprise a first end, a second end, a first surface, a thickness between the first surface and the second surface, a first fluid pathway disposed in the first surface, and a second fluid pathway disposed in the first surface. The first fluid pathway and the second fluid pathway can extend from the first end to the second end. The second layer may have a first end, a second end, a first surface, and a second surface. The second surface of the second layer can be coupled to the first surface of the first layer.

Abstract: A treatment system for applying negative pressure therapy and fluid instillation treatment to a tissue site, particularly an abdominal tissue site, is disclosed. In some embodiments, the treatment system may include a dressing member, a plurality of fluid removal pathways, a fluid instillation matrix, a drape, a negative-pressure source, and a fluid instillation source. Instillation fluid may be delivered from the fluid instillation source to the tissue site through the fluid instillation matrix, and negative pressure may be communicated and fluid withdrawn from the tissue site through the plurality of fluid removal pathways.

Abstract: In some examples, provided is a fluid blockage device for use with a reduced-pressure source for treating a tissue site with reduced pressure. The fluid blockage device may be configured to preclude fluid communication through a port fluidly coupled to the reduced-pressure source when the fluid blockage device contacts a liquid. Other devices, systems, and methods are disclosed.

Abstract: An apparatus for distributing force across a tissue site including a film layer and an embossed layer. The film layer may include a first end and a second end, an aperture near the first end, and a notch extending from the second end to the aperture. The embossed layer may be coupled to the film layer near a periphery of the film layer to define an interior space.

Abstract: A tubeset module includes one or more elements of a negative pressure wound therapy (“NPWT”) system, such as a valve, a calibrated leak, a pressure sensor, etc. The tubeset module may communicate with a controller of the NPWT system via a communications interface provided by the tubeset module. The communication between the tubeset module and the controller may be used to fully automate one or more processes involving the operation of the components of the NPWT system included in the tubeset module, allowing the NPWT system to, e.g. estimate a wound site volume, estimate a volume of fluid to be instilled, monitor wound healing progression, etc. without requiring any user interaction or involvement. The tubeset module may be defined by one or more housing elements. The tubeset module may be incorporated into any of the tubing, fluid canister, wound dressing and/or therapy device housing components of the NPWT system.

Abstract: A process is provided for making a WEE1 inhibitor of the formula (1A) useful in the treatment of conditions characterized by excessive cellular proliferation, such as cancer. In some embodiments, processes are provided for making intermediate compounds of the formulae (3), (5) and (6) as defined herein.