Abstract: A fiber optic laser for use in high stress environments is provided. The fiber optic laser comprises a hollow spool structure housing a fiber in a spiral groove in an interior surface of said hollow spool structure, wherein the fiber is mechanically supported along an entirety of its length within the hollow spool structure. Fluid channels are formed within the hollow spool structure, wherein a quantity of coolant is movable through the fluid channels to provide high-precision thermal management of the fiber.

Abstract: A system and method for passing a fiber cable through a fiber connector is presented. A fiber connector includes an outer body and a series of flutes inside the outer body. The outer body forms an interior chamber that has a first opening and a second opening. The first opening allows a coolant to flow into the first opening and the first and second openings allow the fiber cable to pass through the first opening and the second opening and through the fiber connector. A series of flutes are attached to an inner surface of the outer body and extend into the interior chamber. The flutes are spaced apart from each other and extend from the inner surface toward the fiber cable but do not touch the fiber cable when no liquid is flowing in the fiber connector.

Abstract: A broadband spectral power generator in a multimode optical fiber utilizes a standard multimode fiber that is coiled. A plate is placed on the coiled fiber and a force is applied to compresses the coiled fiber and thereby increase the interactions between the compressed windings and induce modal mixing and birefringence in the fiber. In addition, the compression causes additional non-linear processes to be excited and occur in the compressed fiber coil to generate more broadband light. This allows for better “mixing” of the spatial beam in the multimode fiber coil and allows for the various modes to overlap. The multimode fiber coil is made of silica, silicate, germinate, phosphate, fluoride, chalcogenide, or telluride. The compressed coiled fiber may be driven by a laser providing more than one wavelength output and this greatly increases the amount of nonlinear mixing in the fiber for a greatly enhanced spectral coverage.

Abstract: A system and method for passing a fiber cable through a fiber connector is presented. A fiber connector includes an outer body and a series of flutes inside the outer body. The outer body forms an interior chamber that has a first opening and a second opening. The first opening allows a coolant to flow into the first opening and the first and second openings allow the fiber cable to pass through the first opening and the second opening and through the fiber connector. A series of flutes are attached to an inner surface of the outer body and extend into the interior chamber. The flutes are spaced apart from each other and extend from the inner surface toward the fiber cable but do not touch the fiber cable when no liquid is flowing in the fiber connector.

Abstract: The present invention relates to salts, processes, and process intermediates useful in the preparation of (R)-2-(9-chloro-7-(4-isopropoxy-3-(trifluoromethyl)benzyloxy)-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetic acid of Formula (Ia), salts, and crystalline forms thereof. The compound (R)-2-(9-chloro-7-(4-isopropoxy-3-(trifluoromethyl)benzyloxy)-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetic acid has been identified as an S1P1 receptor modulator that is useful in the treatment of S1P1 receptor-associated disorders, for example, diseases and disorders mediated by lymphocytes, transplant rejection, autoimmune diseases and disorders, inflammatory diseases and disorders (e.g., acute and chronic inflammatory conditions), cancer, and conditions characterized by an underlying defect in vascular integrity or that are associated with angiogenesis such as may be pathologic (e.g., as may occur in inflammation, tumor development, and atherosclerosis).

Abstract: A system provides for a way for cooling an optical fiber. The system includes a coolant and a conduit. The conduit allows the coolant to flow through the conduit. At least part of the fiber passes through the conduit allowing the coolant to flow around the at least part of the fiber. In some configurations, the fiber runs parallel to the conduit. The system can include a pump diode that is part of an optical laser connected to an end of the fiber. The optical laser can further include a high reflector connected to the fiber and a partial reflector connected to the fiber to reflect some light back and forth between the high reflector and the partial reflector.

Abstract: The present invention relates to salts, processes, and process intermediates useful in the preparation of (R)-2-(9-chloro -7-(4-isopropoxy-3-(trifluoromethyl)benzyloxy)-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetic acid of Formula (Ia), salts, and crystalline forms thereof. The compound (R)-2-(9-chloro-7-(4-isopropoxy-3-(trifluoromethyl)benzyloxy)-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetic acid has been identified as an S1P1 receptor modulator that is useful in the treatment of S1P1 receptor-associated disorders, for example, diseases and disorders mediated by lymphocytes, transplant rejection, autoimmune diseases and disorders, inflammatory diseases and disorders (e.g., acute and chronic inflammatory conditions), cancer, and conditions characterized by an underlying defect in vascular integrity or that are associated with angiogenesis such as may be pathologic (e.g., as may occur in inflammation, tumor development, and atherosclerosis).

Abstract: Embodiments of a method and apparatus for controlling the mechanical stabilization of an optical fiber are disclosed. The method may consist of placing an inflatable bladder between an optical fiber and a protective jacket. The bladder may be inflated with air, inert gas, or liquid to a desired pressure. The bladder may be sectioned to extend along part of or the entire length of the fiber. The bladder may isolate the optical fiber in a periodic fashion. The temperature of the material inside the bladder may vary axially along the optical fiber. Embodiments of the invention can stabilize the optical fiber by providing mechanical isolation from vibration and other perturbations. Embodiments of the invention can also alter Stimulated Brillouin Scattering (“SBS”) and Stimulated Raman Scattering (“SRS”) thresholds using either thermal or vibrational perturbations.

Abstract: A system and method for producing Stimulated Raman Scattering (SRS) is disclosed. A single optical fiber or Raman oscillator is optically pumped by a pump laser of sufficient power to generate SRS to generate several Stokes shifts of energy. This generates a multi-wavelength output or a single wavelength with several stokes energy shifts from the pump wavelength. A selective, monolithic-coated Raman fiber oscillator laser is utilized to increase the efficiency of frequency shifting by providing frequency-specific feedback at both facets of a free space coupled optical fiber oscillator. Frequencies that lie several bands away from the primary pump frequency may be efficiently achieved in a fiber oscillator by re-circulating the required stokes-shifted frequencies via selective high-reflection coatings. By re-circulating the intra-band stokes frequencies, the required intensities in each respective frequency will be increased, thereby dropping the respective Raman threshold in the optical fiber.

Abstract: A broadband spectral power generator in a multimode optical fiber utilizes a standard multimode fiber that is coiled. A plate is placed on the coiled fiber and a force is applied to compresses the coiled fiber and thereby increase the interactions between the compressed windings and induce modal mixing and birefringence in the fiber. In addition, the compression causes additional non-linear processes to be excited and occur in the compressed fiber coil to generate more broadband light. This allows for better “mixing” of the spatial beam in the multimode fiber coil and allows for the various modes to overlap. The multimode fiber coil is made of silica, silicate, germinate, phosphate, fluoride, chalcogenide, or telluride. The compressed coiled fiber may be driven by a laser providing more than one wavelength output and this greatly increases the amount of nonlinear mixing in the fiber for a greatly enhanced spectral coverage.

Abstract: The present invention is directed to certain 3H-imidazo[4,5-b]pyridin-5-ol derivatives of Formula (Ia) and pharmaceutically acceptable salts thereof, which exhibit useful pharmacological properties, for example, as agonists of the GPR81 receptor. Also provided by the present invention are pharmaceutical compositions containing compounds of the invention, and methods of using the compounds and compositions of the invention in the treatment of GPR81 associated disorders, for example, dyslipidemia, atherosclerosis, atheromatous disease, hypertension, coronary heart disease, stroke, insulin resistance, impaired glucose tolerance, type 2 diabetes, syndrome X, obesity, psoriasis, rheumatoid arthritis, Crohn's disease, transplant rejection, multiple sclerosis, systemic lupus erythematosus, ulcerative colitis, type 1 diabetes and acne.

Abstract: The present invention relates to salts, processes, and process intermediates useful in the preparation of (R)-2-(9-chloro-7-(4-isopropoxy-3-(trifluoromethyl)benzyloxy)-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetic acid of Formula (Ia), salts, and crystalline forms thereof. The compound (R)-2-(9-chloro-7-(4-isopropoxy-3-(trifluoromethyl)benzyloxy)-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetic acid has been identified as an S1P1 receptor modulator that is useful in the treatment of S1P1 receptor-associated disorders, for example, diseases and disorders mediated by lymphocytes, transplant rejection, autoimmune diseases and disorders, inflammatory diseases and disorders (e.g., acute and chronic inflammatory conditions), cancer, and conditions eases characterized by an underlying defect in vascular integrity or that are associated with angiogenesis such as may be pathologic (e.g., as may occur in inflammation, tumor development, and atherosclerosis).

Abstract: The present invention is directed to certain 3H-imidazo[4,5-b]pyridin-5-ol derivatives of Formula (Ia) and pharmaceutically acceptable salts thereof, which exhibit useful pharmacological properties, for example, as agonists of the GPR81 receptor. Also provided by the present invention are pharmaceutical compositions containing compounds of the invention, and methods of using the compounds and compositions of the invention in the treatment of GPR81 associated disorders, for example, dyslipidemia, atherosclerosis, atheromatous disease, hypertension, coronary heart disease, stroke, insulin resistance, impaired glucose tolerance, type 2 diabetes, syndrome X, obesity, psoriasis, rheumatoid arthritis, Crohn's disease, transplant rejection, multiple sclerosis, systemic lupus erythematosus, ulcerative colitis, type 1 diabetes and acne.

Abstract: System for selecting a color shade comprising a very small number of color display cards with mixed shades of two or more colors. The system comprises means for selecting one shade among mixed shades, means for presenting the selected mixed shade as well as means for specifying the selected mixed shade for making paint in the desired color tone.

Abstract: A transducer assembly for receiving a stimulating signal and producing ultrasound therefrom at one or more frequencies, over an ultrabroad bandwidth at each frequency, includes a front mass disposed about a central axis, and a back mass disposed about the central axis, laterally offset from the front mass. The transducer assembly also includes one or more resonators disposed about the central axis and between the front mass and the back mass, including at least one electrical contact for receiving the stimulating signal. The back mass consists of a low-density material, such as aluminum, aluminum alloy, magnesium, or magnesium alloy, or any of various low-density materials known in the art. In general, the back mass is characterized by a density of less than 6.0 g/cc. In one embodiment, the front mass and the back mass are made from different materials, and the front mass includes a deviation from symmetrical symmetry.

Abstract: A transducer assembly for receiving a stimulating signal and producing ultrasound therefrom at one or more frequencies, over an ultrabroad bandwidth at each frequency, includes a front mass disposed about a central axis, and a back mass disposed about the central axis, laterally offset from the front mass. The transducer assembly also includes one or more resonators disposed about the central axis and between the front mass and the back mass, including at least one electrical contact for receiving the stimulating signal. The back mass consists of a low-density material, such as aluminum, aluminum alloy, magnesium, or magnesium alloy, or any of various low-density materials known in the art. In general, the back mass is characterized by a density of less than 6.0 g/cc. In one embodiment, the front mass and the back mass are made from different materials, and the front mass includes a deviation from symmetrical symmetry.