Abstract: The present disclosure provides laminates, which include adhesive materials and methods that allow for the removal of contaminants, e.g. particulate contaminants, from a substrate surface. In one embodiment, the laminates include (i) a substrate with contaminant disposed on its surface, (ii) a liquid, adhesive precursor and (iii) a film layer. The liquid, adhesive precursor is disposed between the substrate and the film layer. In another embodiment, the laminates include (i) a substrate with contaminant disposed on its surface, (ii) a cured adhesive layer and (iii) a film layer. The cured adhesive layer is disposed between the substrate and the film layer. The laminates may be used to remove contaminant from the substrate surface by removal of the film layer and the cured adhesive layer, which entraps the contaminant therein.

Abstract: Disclosed are methods of treating a subject, such as those having or at risk of cardiomyopathies, with an effective amount of a recombinant adeno-associated virus (rAAV) virion, the rAAV virion comprising an AAV capsid and an expression cassette comprising a polynucleotide encoding a DWORF polypeptide operatively linked to a promoter. Compositions and kits relating to the same are also disclosed.

Abstract: The present disclosure describes a new native peptide designated herein as Dwarf Open Reading Frame, or DWORF. This peptide enhances the apparent activity of the SERCA pump, is positively inotropic and lusitropic, and therefore is provided as a therapeutic agent for disorders characterized by cytosolic calcium overload.

Abstract: The present disclosure describes a new native peptide designated herein as Dwarf Open Reading Frame, or DWORF. This peptide enhances the apparent activity of the SERCA pump, is positively inotropic and lusitropic, and therefore is provided as a therapeutic agent for disorders characterized by cytosolic calcium overload.

Abstract: The present disclosure describes a new native peptide designated herein as Dwarf Open Reading Frame, or DWORF. This peptide enhances the apparent activity of the SERCA pump, is positively inotropic and lusitropic, and therefore is provided as a therapeutic agent for disorders characterized by cytosolic calcium overload.

Abstract: The present disclosure describes a new native peptide designated herein as Dwarf Open Reading Frame, or DWORF. This peptide enhances the apparent activity of the SERCA pump, is positively inotropic and lusitropic, and therefore is provided as a therapeutic agent for disorders characterized by cytosolic calcium overload.

Abstract: The present disclosure describes a new native peptide designated herein as Dwarf Open Reading Frame, or DWORF. This peptide enhances the apparent activity of the SERCA pump, is positively inotropic and lusitropic, and therefore is provided as a therapeutic agent for disorders characterized by cytosolic calcium overload.

Abstract: For the hydraulic brake system of a vehicle such as a farm or industrial tractor having brakes on the right and left rear wheels for both braking and steering, flow control means operatively interconnecting a source of hydraulic pressure available when the vehicle is operating, a hydraulic fluid reservoir and a manually actuated brake applicator means such as a brake pedal, so as to provide power braking. The flow control means also provides for manual braking when hydraulic pressure is not available. A separate relatively large fill piston and small pressurizing piston used in manual braking are in combination with the power brake valve. An unloading valve is provided for cooperation with the fill piston during both the power and manual modes.