Abstract: The present disclosure relates to methods and intermediates useful for preparing a compound of formula I: or a co-crystal, solvate, salt or combination thereof.

Abstract: A tank comprising a rounded bottom section with an inlet located at the lowest point of the rounded bottom section having openings to direct fluid against the curved side walls to form a circulation cell. An outlet is provided inside the tank located above and in close proximity to the inlet. The design of the tank, inlet and outlet provide a circulation pattern that can mix, maintain and resuspend fluids and slurries.

Abstract: A tank comprising a rounded bottom section with an inlet located at the lowest point of the rounded bottom section having openings to direct fluid against the curved side walls to form a circulation cell. An outlet is provided inside the tank located above and in close proximity to the inlet. The design of the tank, inlet and outlet provide a circulation pattern that can mix, maintain and resuspend fluids and slurries.

Abstract: A method and apparatus for producing a liquid mixture in which mixture components are mixed to produce a product stream having a predetermined connection of a specified component. This mixing occurs within a fluidic network designed such that the components mix in inlet branches to form a first intermediate mixture having a lower concentration than that desired in the product stream. The specified component is metered into the intermediate product stream to produce a second intermediate product stream that is blended to produce a third intermediate product stream. The concentration of the specified component within the third intermediate product stream is measured and the metering pump is appropriately adjusted. The third intermediate product stream then passes through a recycle loop in which recycled product is mixed with an intermediate product stream to produce a liquid mixture stream that is divided into the recycle stream and a product stream.

Abstract: A method and apparatus for producing a liquid mixture in which mixture components are mixed to produce a product stream having a predetermined concentration of a specified component. This mixing occurs within a fluidic network designed such that the components mix in inlet branches to form a first intermediate mixture having a lower concentration than that desired in the product stream. The specified component is metered into the intermediate product stream to produce a second intermediate product stream that is blended to produce a third intermediate product stream. The concentration of the specified component within the third intermediate product stream is measured and the metering pump is appropriately adjusted. The third intermediate product stream then passes through a recycle loop in which recycled product is mixed with an intermediate product stream to produce a liquid mixture stream that is divided into the recycle stream and a product stream.

Abstract: A system and method for dispensing an aqueous solution to one or more points of use is provided with one or more pressure vessels that are adapted to be charged with pressurized gas to drive the aqueous solution on to the point or points of use. A humidifier is also employed to humidify the pressurized gas to at least inhibit the pressurized gas from evaporating the moisture from the aqueous solution. In such manner, changes to the make up of the aqueous solution are avoided. Such changes can produce caking and/or changes in chemical properties found in pressure vessels used in dispensing slurries.

Abstract: A valve manifold box system and method in which one or more dispense units dispense chemical to a plurality points of use. A fluid circuit is provided with valve manifolds connected in series by double walled conduits known as containment pipes. The fluid circuit is either in the form of a loop of a series of valve manifolds alternating with double walled piping so that each valve manifold is fed with chemical at opposite ends. Alternately, two dispense units could be connected to the end of an in-line type of fluid circuit. The valve manifolds are contained within valve boxes and the ends of the containment pipes are connected to the valve boxes. In this manner a leak in either the valve manifolds or the containment pipes collects within the valve boxes. Leak detectors are provided in the valve boxes and upon the sensing of a leak, the potentially leaking valve manifold as well as the associated, adjacent containment pipes feeding such valve manifold are isolated by isolation valves.

Abstract: A liquid dispensing method and apparatus in which liquid is dispensed from chambers, that can be pressure vessels, to a flow circuit. A valve network is designed such that when one chamber functions in a dispense mode of operation another chamber functions in a return mode of operation in which unused liquid is sent back to such chamber so that liquid is continually circulated. The chamber or vessel undergoing the return mode of operation is vented through a valve that is either a pressure regulation valve having a set point of pressure or a remotely activated control valve response to liquid pressure at the point of use. In such manner internal pressure within the chamber or pressure vessel undergoing the return mode of operation is regulated to in turn regulate liquid pressure at the point of use.

Abstract: An apparatus and method for producing a slurry from a slurry concentrate in which streams of slurry concentrate, de-ionized water and oxidizer are pumped to form three pumped streams that are brought together to form a mixture. Homogeneity is promoted within the mixture by such devices as a static mixer and an in-line mixer of special design. The resultant homogenous stream is then pumped to dispense pressure by a dispense pump to produce a dispense stream. Part of the dispense stream, preferably about fifty percent, is recycled back to a junction at which the pumped streams join to further promote homogeneity of the slurry. For such purpose a flow network is connected to an outlet pump and such flow network is branched so as to have a dispense leg from which the dispense stream issues and a recycle leg connected to the junction for recirculating the recycle stream.

Abstract: A modular, enclosed, interchangeable hazardous material treatment plant is disclosed. The treatment plant can utilize any one of a variety of abatement technologies for treating an unauthorized discharge of hazardous material, including spray aeration, vacuum extraction, biological, carbon, ozone, ultra-violet, or other. Regardless of the type of plant, connection to the site is made between the enclosed plant and the standard underground connection port which contains connection to all underground piping. No on-site assembly or disassembly of the plant is required. If a succession of treatment plants is required, one can be disconnected and the next connected within an hour. During treatment, all that is visible above ground is the enclosure. After treatment of the site is complete, the only visible remainder of the plant is the cover of the underground connection port.

Abstract: A pump driven by air only is disclosed for providing simultaneous aeration and flow at right angles to the rising air. The pump produces in a shallow tank particle-suspending turbulence which is particularly useful for growth of marine organisms in a sun-exposed tank confined shallow brine solution. The pump is preferably installed in a rectangular tank divided by a baffle between the two tank side walls. The baffle extends parallel to the major axes of the rectangle and stops short of both tank end walls. The fluid is pumped around this baffle in an oval flow pattern. On the shallow bottom of the tank on both sides of the baffle, there is a repeating foil shaped bottom with a manifold for discharging air. The foils of the bottom are generated at right angles to the baffle and oriented from leading edge to trailing edge in the direction of intended fluid rotation around the baffle in the tank. Air is pumped and discharged from the manifold in a rising curtain.