Abstract: Medical devices with a plastic albumin body with a defined three dimensional shape that are particularly suitable for pressure equalization tubes. The plastic albumin body can be a unitary substantially monolithic body of albumin. The plastic albumin body has an antibacterial property such that it is resistant to bacterial adhesions and/or bacterial biofilm formation thereon. Methods and processes are described for forming a consolidated protein-based coating on an implant, and coated implants produced therefrom, with improved biocompatibility, nonthrombogenity and antimicrobiality that are suitable for various medical implants and drug delivery devices, such as bone implants, catheters, cannuale, guide wires, stents, shunts, vascular grafts, heart valves, heart and ventricular assist devices, oxygenators, dialyzers, medical devices, and other substrates, such as furniture, keyboards, etc.