Abstract: Hemostasis valve devices and methods of use are disclosed. The hemostasis valve devices include a body member, a slide member, an introducer member, a valve cap, and a valve member. The body member and slide member can be gripped by a user's finger and thumb, respectively. The slide member can be distally displaced by the user's thumb to distally displace the introducer member through the valve member to open the valve member to allow passage of a medical appliance through the valve member. The introducer member can be selectively locked in a distal position to keep the valve open.

Abstract: A system for compressing neural signal data using spatiotemporal data compression techniques. The system includes an implantable neural that receives electrophysiologic signal data from the electrode array, maps the electrophysiologic signal data to locations of each of the plurality of the electrodes, and compresses the mapped electrophysiologic signal data based on the locations of the plurality of electrodes utilizing a spatiotemporal data compression algorithm to define compressed electrophysiologic signal data. The implantable neural device can be connectable to a computer system that decompressed the electrophysiologic data for various downstream applications.

Abstract: A method and system for decoding speech based on recorded brain signals is provided. The method can include receiving recorded brain signals via a microelectrode array. The method can include extracting one or more features from the recorded brain signals. The method can include converting the one or more extracted features into one or more feature embeddings. The method can include transforming, by one or more encoders, the one or more feature embeddings. The method can include predicting, by one or more decoders, phonemes based on the one or more transformed feature embeddings. The method can include predicting speech based on the predicted phonemes.

Abstract: A non-invasive intranasal neuromodulation system is configured to stimulate the sphenopalatine ganglion (SPG) to increase the collateral blood flow and mitigate brain perfusion to treat the symptoms and improve outcomes of acute stroke care, the non-invasive intranasal neuromodulation system comprising a catheter having a first balloon coupled to and surrounding the catheter,? the first balloon including at least one electrode; and a second balloon coupled to and surrounding the catheter; wherein the first balloon and the second balloon are configured and are spaced apart from one another such that in inflated states of the first balloon and the second balloon, the first balloon is configured to contact or be proximate to the sphenopalatine ganglion to permit stimulation thereof by actuation of the at least one electrode, while the second balloon is configured to hold the non-invasive neuromodulation device in place within the nasopharynx.

Abstract: Systems and methods for hermetic sealing a neural interface. The neural interface can include a substrate, an electronics subassembly disposed on the substrate, an electrode array coupled to the substrate defining a first interface, wherein the electrode array comprises a plurality of electrodes disposed at a distal end thereof, a lead wire coupled to the substrate, and an encapsulation layer covering the electronics, the first interface, and the second interface. The encapsulation layer comprises a low vapor permeability material and is configured to hermetically seal the electronics, the first interface, and the second interface from a biological environment.

Abstract: A system for performing spinal cord stimulation on a subject is disclosed. The system comprises one or more recording arrays, at least one stimulation array, and a processor. The recording arrays, which may be minimally invasively inserted to a target recording site of the brain, include recording electrodes having a diameter of less than about 1 mm and having a spacing of less than about 1 mm therebetween. The stimulation array, which may be minimally invasively inserted to a target stimulation site within the nervous tissue, includes stimulation electrodes. The processor is configured to receive more recorded signals from the recording arrays at the target recording site, determine an electrophysiological state of the brain based on the recorded signals, and deliver electrical stimulation to the target stimulation site through the stimulation array based on the determined electrophysiological state in order to affect the electrophysiological state.

Abstract: A system for compressing neural signal data using spatiotemporal data compression techniques. The system includes an implantable neural that receives electrophysiologic signal data from the electrode array, maps the electrophysiologic signal data to locations of each of the plurality of the electrodes, and compresses the mapped electrophysiologic signal data based on the locations of the plurality of electrodes utilizing a spatiotemporal data compression algorithm to define compressed electrophysiologic signal data. The implantable neural device can be connectable to a computer system that decompressed the electrophysiologic data for various downstream applications.