Patents by Inventor Benjamin Richards Umiker

Benjamin Richards Umiker has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS FOR THE TREATMENT OF CANCER
    Publication number: 20220289847
    Abstract: The invention provides methods of treating cancer and methods for selecting approaches for treatment of cancer.
    Type: Application
    Filed: March 9, 2022
    Publication date: September 15, 2022
    Inventors: Lara Lewis MCGRATH, Amy Jiayue MUELLER, Karen Suzanne BROWN, Benjamin Richards UMIKER, Yasmin Lucy RAMSAY
  • IN VITRO GASTROINTESTINAL MODEL COMPRISING LAMINA PROPRIA-DERIVED CELLS
    Publication number: 20220081663
    Abstract: An in vitro microfluidic gut-on-chip is described herein that mimics the structure and at least one function of specific areas of the gastrointestinal system in vivo. In particular, a multicellular, layered, microfluidic culture is described, allowing for interactions between lamina propria-derived cells and gastrointestinal epithelial cells and endothelial cells. This in vitro microfluidic system can be used for modeling inflammatory gastrointestinal tissue, e.g., Crohn's disease, colitis and other inflammatory gastrointestinal disorders. These multicellular, layered microfluidic gut-on-chip further allow for comparisons between types of gastrointestinal tissues, e.g., small intestinal deuodejeum, small intestinal ileium, large intestinal colon, etc., and between disease states of gastrointestinal tissue, i.e. healthy, pre-disease and diseased areas.
    Type: Application
    Filed: November 16, 2021
    Publication date: March 17, 2022
    Inventors: S. Jordan Kerns, Jenifer Obrigewitch, Micheal Salmon, Benjamin Richards Umiker
  • In vitro gastrointestinal model comprising lamina propria-derived cells
    Patent number: 11230688
    Abstract: An in vitro microfluidic gut-on-chip is described herein that mimics the structure and at least one function of specific areas of the gastrointestinal system in vivo. In particular, a multicellular, layered, microfluidic culture is described, allowing for interactions between lamina propria-derived cells and gastrointestinal epithelial cells and endothelial cells. This in vitro microfluidic system can be used for modeling inflammatory gastrointestinal tissue, e.g., Crohn's disease, colitis and other inflammatory gastrointestinal disorders. These multicellular, layered microfluidic gut-on-chip further allow for comparisons between types of gastrointestinal tissues, e.g., small intestinal deuodejeum, small intestinal ileium, large intestinal colon, etc., and between disease states of gastrointestinal tissue, i.e. healthy, pre-disease and diseased areas.
    Type: Grant
    Filed: November 21, 2017
    Date of Patent: January 25, 2022
    Assignee: EMULATE, INC.
    Inventors: S. Jordan Kerns, Jenifer Obrigewitch, Michael Salmon, Benjamin Richards Umiker
  • In vitro gastrointestinal model comprising lamina propria-derived cells
    Patent number: 11001795
    Abstract: An in vitro microfluidic gut-on-chip is described herein that mimics the structure and at least one function of specific areas of the gastrointestinal system in vivo. In particular, a multicellular, layered, microfluidic culture is described, allowing for interactions between lamina propria-derived cells and gastrointestinal epithelial cells and endothelial cells. This in vitro microfluidic system can be used for modeling inflammatory gastrointestinal tissue, e.g., Crohn's disease, colitis and other inflammatory gastrointestinal disorders. These multicellular, layered microfluidic gut-on-chip further allow for comparisons between types of gastrointestinal tissues, e.g., small intestinal deuodejeum, small intestinal ileium, large intestinal colon, etc., and between disease states of gastrointestinal tissue, i.e. healthy, pre-disease and diseased areas.
    Type: Grant
    Filed: November 21, 2017
    Date of Patent: May 11, 2021
    Assignee: Emulate, Inc.
    Inventors: S. Jordan Kerns, Jenifer Obrigewitch, Michael Salmon, Magdalena Kasendra, Benjamin Richards Umiker
  • IN VITRO GASTROINTESTINAL MODEL COMPRISING LAMINA PROPRIA-DERIVED CELLS
    Publication number: 20180230417
    Abstract: An in vitro microfluidic gut-on-chip is described herein that mimics the structure and at least one function of specific areas of the gastrointestinal system in vivo. In particular, a multicellular, layered, microfluidic culture is described, allowing for interactions between lamina propria-derived cells and gastrointestinal epithelial cells and endothelial cells. This in vitro microfluidic system can be used for modeling inflammatory gastrointestinal tissue, e.g., Crohn's disease, colitis and other inflammatory gastrointestinal disorders. These multicellular, layered microfluidic gut-on-chip further allow for comparisons between types of gastrointestinal tissues, e.g., small intestinal deuodejeum, small intestinal ileium, large intestinal colon, etc., and between disease states of gastrointestinal tissue, i.e. healthy, pre-disease and diseased areas.
    Type: Application
    Filed: November 21, 2017
    Publication date: August 16, 2018
    Inventors: S. Jordan Kerns, Jenifer Obrigewitch, Michael Salmon, Benjamin Richards Umiker
  • IN VITRO GASTROINTESTINAL MODEL COMPRISING LAMINA PROPRIA-DERIVED CELLS
    Publication number: 20180224432
    Abstract: An in vitro microfluidic gut-on-chip is described herein that mimics the structure and at least one function of specific areas of the gastrointestinal system in vivo. In particular, a multicellular, layered, microfluidic culture is described, allowing for interactions between lamina propria-derived cells and gastrointestinal epithelial cells and endothelial cells. This in vitro microfluidic system can be used for modeling inflammatory gastrointestinal tissue, e.g., Crohn's disease, colitis and other inflammatory gastrointestinal disorders. These multicellular, layered microfluidic gut-on-chip further allow for comparisons between types of gastrointestinal tissues, e.g., small intestinal deuodejeum, small intestinal ileium, large intestinal colon, etc., and between disease states of gastrointestinal tissue, i.e. healthy, pre-disease and diseased areas.
    Type: Application
    Filed: November 21, 2017
    Publication date: August 9, 2018
    Inventors: S. Jordan Kerns, Jenifer Obrigewitch, Michael Salmon, Magdalena Kasendra, Benjamin Richards Umiker