Patents by Inventor Benjamin ROSCOE

Benjamin ROSCOE has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • A FILM-FORMING COMPOSITION COMPRISING PECTIN
    Publication number: 20240408025
    Abstract: The present specification relates to a film-forming composition comprising high ester (HE) pectin as a film-forming polymer, water and optionally a plasticizer. This specification further relates to capsules comprising soft or hard capsule shells made from said film-forming composition.
    Type: Application
    Filed: August 18, 2022
    Publication date: December 12, 2024
    Inventors: Rebecca Putans, Benjamin Roscoe, Michael Baumann
  • Targeting BCL11A distal regulatory elements with a CAS9-CAS9 fusion for fetal hemoglobin reinduction
    Patent number: 12098363
    Abstract: Provided herein are methods and compositions for increasing fetal hemoglobin levels in a cell by disrupting BCL11A expression at the genomic level. Also provided herein are methods and compositions relating to the treatment of hemoglobinopathies by reinduction of fetal hemoglobin levels.
    Type: Grant
    Filed: July 20, 2018
    Date of Patent: September 24, 2024
    Assignees: THE CHILDREN'S MEDICAL CENTER CORPORATION, UNIVERSITY OF MASSACHUSETTS
    Inventors: Daniel E. Bauer, Scot Wolfe, Mehmet Fatih Bolukbasi, Benjamin Roscoe, Pengpeng Liu, Kevin Luk, Yuxuan Wu, Jing Zeng
  • BARCODABLE EXCHANGEABLE PEPTIDE-MHC MULTIMER LIBRARIES
    Publication number: 20230287394
    Abstract: MHC multimers are provided in which peptide-loaded MHC monomers are covalently linked to a multimerization domain through conjugation moieties on the monomers and the multimerization domain. The multimers can further comprise oligonucleotide barcodes. Peptide exchange can be performed with a plurality of pMHC multimers to create pMHC multimer libraries. Methods of making and using the pMHC multimers and libraries are also provided. Peptide-loaded MHC Class I and MHC Class II multimers, and libraries thereof, are provided.
    Type: Application
    Filed: March 31, 2021
    Publication date: September 14, 2023
    Inventors: Ohad Yosefson, Thomas Malia, Andrew Hamel, Joanna Swain, Benjamin Roscoe, Mohammad Rashidian
  • TARGETING BCL11A DISTAL REGULATORY ELEMENTS WITH A CAS9-CAS9 FUSION FOR FETAL HEMOGLOBIN REINDUCTION
    Publication number: 20210047632
    Abstract: Provided herein are methods and compositions for increasing fetal hemoglobin levels in a cell by disrupting BCL11A expression at the genomic level. Also provided herein are methods and compositions relating to the treatment of hemoglobinopathies by reinduction of fetal hemoglobin levels.
    Type: Application
    Filed: July 20, 2018
    Publication date: February 18, 2021
    Applicants: THE CHILDREN'S MEDICAL CENTER CORPORATION, UNIVERSITY OF MASSACHUSETTS
    Inventors: Daniel E. BAUER, Scot WOLFE, Mehmet Fatih BOLUKBASI, Benjamin ROSCOE, Pengpeng LIU, Kevin LUK, Yuxuan WU, Jing ZENG