Patents by Inventor Benjamin Rosenbluth
Benjamin Rosenbluth has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230295706Abstract: Aspects of the disclosure relate to compositions and methods for amplifying and/or detecting one or more target nucleic acid sequences (e.g., a nucleic acid sequence of one or more pathogens) in a biological sample obtained from a subject. In some embodiments, the pathogens are viral, bacterial, fungal, parasitic, or protozoan pathogens, such as SARS-CoV-2 or an influenza virus. In some embodiments, the methods comprise isothermal amplification of a target nucleic acid and subsequent detection of the amplification products.Type: ApplicationFiled: January 12, 2023Publication date: September 21, 2023Applicants: Detect, Inc., Board of Regents, The University of Texas SystemInventors: Spencer Glantz, Jonathan M. Rothberg, Xinghua Shi, Benjamin Rosenbluth, Jaymin Patel, William A. Hansen, Jonathan Naccache, Hope Kronman, Henry Kemble, Caixia Lv, Andrew Ellington, Sanchita Bhadra
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Patent number: 11737665Abstract: Aspects of the present disclosure provide improved techniques for imaging a subject's retina fundus. Some aspects relate to an imaging apparatus that may be substantially binocular shaped and/or may house multiple imaging devices configured to provide multiple corresponding modes of imaging the subject's retina fundus. Some aspects relate to techniques for imaging a subject's eye using white light, fluorescence, infrared (IR), optical coherence tomography (OCT), and/or other imaging modalities that may be employed by a single imaging apparatus. Some aspects relate to improvements in white light, fluorescence, IR, OCT, and/or other imaging technologies that may be employed alone or in combination with other techniques. Some aspects relate to multi-modal imaging techniques that enable determination of a subject's health status.Type: GrantFiled: June 19, 2020Date of Patent: August 29, 2023Assignee: Tesseract Health, Inc.Inventors: Tyler S. Ralston, Maurizio Arienzo, Owen Kaye-Kauderer, Benjamin Rosenbluth, Jonathan M. Rothberg, Lawrence C. West, Paul E. Glenn
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Publication number: 20230220465Abstract: Aspects of the disclosure relate to compositions and methods for amplifying and/or detecting one or more target nucleic acid sequences (e.g., a nucleic acid sequence of one or more pathogens) in a biological sample obtained from a subject. In some embodiments, the pathogens are viral, bacterial, fungal, parasitic, or protozoan pathogens, such as SARS-CoV-2 or an influenza virus. In some embodiments, the methods comprise isothermal amplification of a target nucleic acid and subsequent detection of the amplification products.Type: ApplicationFiled: January 12, 2023Publication date: July 13, 2023Applicant: Detect, Inc.Inventors: Spencer Glantz, Jonathan M. Rothberg, Xinghua Shi, Benjamin Rosenbluth, Jaymin Patel, William A. Hansen, Jonathan Naccache, Hope Kronman, Henry Kemble, Caixia Lv
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Patent number: 11435177Abstract: Aspects of the present disclosure provide improved techniques for imaging a subject's retina fundus. Some aspects relate to an imaging apparatus that may be substantially binocular shaped and/or may house multiple imaging devices configured to provide multiple corresponding modes of imaging the subject's retina fundus. Some aspects relate to techniques for imaging a subject's eye using white light, fluorescence, infrared (IR), optical coherence tomography (OCT), and/or other imaging modalities that may be employed by a single imaging apparatus. Some aspects relate to improvements in white light, fluorescence, IR, OCT, and/or other imaging technologies that may be employed alone or in combination with other techniques. Some aspects relate to multi-modal imaging techniques that enable determination of a subject's health status.Type: GrantFiled: June 19, 2020Date of Patent: September 6, 2022Assignee: Tesseract Health, Inc.Inventors: Tyler S. Ralston, Maurizio Arienzo, Owen Kaye-Kauderer, Benjamin Rosenbluth, Jonathan M. Rothberg, Lawrence C. West, Paul E. Glenn
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Publication number: 20220040699Abstract: Provided herein, in some embodiments, are rapid diagnostic tests to detect one or more target nucleic acid sequences (e.g., a nucleic acid sequence of one or more pathogens). In some embodiments, the pathogens are viral, bacterial, fungal, parasitic, or protozoan pathogens, such as SARS-CoV-2 or an influenza virus. In one embodiment, a diagnostic system is provided comprising a control device configured to control one or more parameters and/or actions of a diagnostic test, and a test kit component comprising a physical encoding of control information for the control device. In one embodiment, the control device is configured to receive the control information of the physical encoding and perform one or more actions based at least in part on the control information. In one embodiment, the control device can control one or more temperatures at which a biological sample is to be processed as part of the diagnostic test.Type: ApplicationFiled: August 9, 2021Publication date: February 10, 2022Applicant: Detect, Inc.Inventors: Jonathan M. Rothberg, Benjamin Rosenbluth, Todd Roswech
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Publication number: 20210378643Abstract: Provided herein, in some embodiments, are breakable swabs for sample collection. In some embodiments, the swabs may be used in rapid diagnostic tests to detect one or more target nucleic acid sequences (e.g., a nucleic acid sequence of one or more pathogens). In some embodiments, the pathogens are viral, bacterial, fungal, parasitic, or protozoan pathogens, such as SARS-CoV-2 or an influenza virus. The swab may include a stem portion for handling and a head portion for collecting and/or holding a sample. After sample collection, the head portion may be inserted into a reaction tube or any other sample-receiving device. The stem portion of the swab may then be separated or detached from the head portion along a breakable portion.Type: ApplicationFiled: June 3, 2021Publication date: December 9, 2021Applicant: Detect, Inc.Inventors: Todd Roswech, Jonathan M. Rothberg, Spencer Glantz, Benjamin Rosenbluth
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Publication number: 20210315456Abstract: Aspects of the present disclosure provide improved techniques for imaging a subject's retina fundus. Some aspects relate to an imaging apparatus that may be substantially binocular shaped and/or may house multiple imaging devices configured to provide multiple corresponding modes of imaging the subject's retina fundus. Some aspects relate to techniques for imaging a subject's eye using white light, fluorescence, infrared (IR), optical coherence tomography (OCT), and/or other imaging modalities that may be employed by a single imaging apparatus. Some aspects relate to improvements in white light, fluorescence, IR, OCT, and/or other imaging technologies that may be employed alone or in combination with other techniques. Some aspects relate to multi-modal imaging techniques that enable determination of a subject's health status.Type: ApplicationFiled: June 19, 2020Publication date: October 14, 2021Applicant: Tesseract Health, Inc.Inventors: Tyler S. Ralston, Maurizio Arienzo, Owen Kaye-Kauderer, Benjamin Rosenbluth, Jonathan M. Rothberg, Lawrence C. West, Paul E. Glenn
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Publication number: 20210292825Abstract: Provided herein are rapid diagnostic tests, systems, and methods for detecting one or more target nucleic acid sequences (e.g., a nucleic acid sequence of one or more pathogens, such as SARS-CoV-2 or an influenza virus) using isothermal nucleic acid amplification. The tests, systems, and methods described herein may be performed in a point-of-care setting or a home setting without specialized equipment.Type: ApplicationFiled: March 16, 2021Publication date: September 23, 2021Applicant: Detect, Inc.Inventors: Jonathan M. Rothberg, Spencer Glantz, Benjamin Rosenbluth, Matthew Dyer, Todd Roswech, Eric Kauderer-Abrams, Jose Camara
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Publication number: 20210293805Abstract: Described herein in one embodiment is a computer-implemented method comprising accessing information representing a detection component of a diagnostic test and determining, based at least in part on the information representing the detection component of the diagnostic test, results of the diagnostic test. Described herein in one embodiment is a method of performing a diagnostic test on a subject. In one embodiment, the method comprises obtaining a sample from the subject, processing the sample, analyzing the sample with a detection component of the diagnostic test, and performing a computer-implemented method comprising accessing information representing the detection component of a diagnostic test, and determining, based at least in part on the information representing the detection component of the diagnostic test, results of the diagnostic test.Type: ApplicationFiled: March 16, 2021Publication date: September 23, 2021Applicant: Detect, Inc.Inventors: Jonathan M. Rothberg, Benjamin Rosenbluth
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Publication number: 20210293815Abstract: Provided herein, in some embodiments, are rapid diagnostic tests comprising a lateral flow strip and an integrated swab head. The tests may be used to detect, for example, one or more pathogens, such as viral, bacterial, fungal, parasitic, or protozoan pathogens. Further embodiments provide methods of detecting genetic abnormalities. Nucleic acid tests using the diagnostic tests are provided.Type: ApplicationFiled: October 9, 2020Publication date: September 23, 2021Applicant: Detect, Inc.Inventors: Jonathan M. Rothberg, Spencer Glantz, Benjamin Rosenbluth, Owen Kaye-Kauderer
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Publication number: 20210291165Abstract: Provided herein, in some embodiments, are rapid diagnostic tests to detect one or more target nucleic acid sequences (e.g., a nucleic acid sequence of one or more pathogens). In some embodiments, the pathogens are viral, bacterial, fungal, parasitic, or protozoan pathogens, such as SARS-CoV-2 or an influenza virus. Further embodiments provide methods of detecting genetic abnormalities. Diagnostic tests comprising a sample-collecting component, one or more reagents (e.g., lysis reagents, nucleic acid amplification reagents), and a detection component (e.g., a component comprising a lateral flow assay strip and/or a colorimetric assay) are provided.Type: ApplicationFiled: March 16, 2021Publication date: September 23, 2021Applicant: Detect, Inc.Inventors: Jonathan M. Rothberg, Spencer Glantz, Benjamin Rosenbluth, Todd Roswech, Matthew Dyer, Jose Camara, Eric Kauderer-Abrams, Jonathan C. Schultz
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Publication number: 20210291181Abstract: Provided herein, in some embodiments, are rapid diagnostic tests to detect one or more target nucleic acid sequences (e.g., a nucleic acid sequence of one or more pathogens) having a seal component. In some embodiments, the pathogens are viral, bacterial, fungal, parasitic, or protozoan pathogens, such as SARS-CoV-2 or an influenza virus. Further embodiments provide methods of detecting genetic abnormalities. Diagnostic tests comprising a sample-collecting component, one or more reagents (e.g., lysis reagents, nucleic acid amplification reagents), a seal component, and a detection component (e.g., a component comprising a lateral flow assay strip and/or a colorimetric assay) are provided.Type: ApplicationFiled: March 16, 2021Publication date: September 23, 2021Applicant: Detect, Inc.Inventors: Jonathan M. Rothberg, Spencer Glantz, Benjamin Rosenbluth
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Publication number: 20210295954Abstract: Described herein in one embodiment is software, which may be downloaded to a device, to guide a user through administration of a test. Test results may be uploaded, manually or automatically, to a device or communicated remotely through a network. In an embodiment, the test is a rapid test. In an embodiment, the rapid test detects presence of COVID-19. In an embodiment, the rapid test detects COVID-19 or influenza. In an embodiment, the rapid test detects influenza A or influenza B. In an embodiment, the rapid test detects a target nucleic acid. In an embodiment, the target nucleic acid represents one of a viral, bacterial, fungal, parasitic or protozoan pathogen. Each of the rapid tests may be self administrable.Type: ApplicationFiled: March 16, 2021Publication date: September 23, 2021Applicant: Detect, Inc.Inventors: Jonathan M. Rothberg, Benjamin Rosenbluth
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Publication number: 20210291177Abstract: A reagent carrier includes: a cap configured to fit on an opening of a reaction vessel; and a reagent confined by the cap. The cap may be configured to release the reagent when a user manipulates the cap while the cap is fitted on the opening of the reaction vessel. For example, the reagent may be released when the user twists the cap from a first position to a second position or when the user pushes on a surface of the cap. The cap may be configured to seal the opening of the reaction vessel when the cap is fitted on the opening of the reaction vessel. In some implementations, the cap may be a blister cap containing the reagent. In some implementations, the cap may include a cage containing the reagent. In some implementations, the cap may include a deformable structure containing the reagent.Type: ApplicationFiled: March 16, 2021Publication date: September 23, 2021Applicant: Detect, Inc.Inventors: Jonathan M. Rothberg, Spencer Glantz, Benjamin Rosenbluth, Todd Roswech, Eric Kauderer-Abrams, Matthew Dyer, Jose Camara, Owen Kaye-Kauderer, John H. Leamon
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Publication number: 20210292855Abstract: Described herein in one embodiment is software, which may be downloaded to a device, to guide a user through administration of a test. Test results may be uploaded, manually or automatically, to a device or communicated remotely through a network. In an embodiment, the test is a rapid test. In an embodiment, the rapid test detects presence of COVID-19. In an embodiment, the rapid test detects COVID-19 or influenza. In an embodiment, the rapid test detects influenza A or influenza B. In an embodiment, the rapid test detects a target nucleic acid. In an embodiment, the target nucleic acid represents one of a viral, bacterial, fungal, parasitic or protozoan pathogen. Each of the rapid tests may be self administrable.Type: ApplicationFiled: March 16, 2021Publication date: September 23, 2021Applicant: Detect, Inc.Inventors: Jonathan M. Rothberg, Spencer Glantz, Benjamin Rosenbluth
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Publication number: 20210174893Abstract: The present disclosure provides, in some aspects, methods for using FRET-based distance measurements to refine and constrain protein structure prediction algorithms.Type: ApplicationFiled: December 10, 2020Publication date: June 10, 2021Applicant: Homodeus, Inc.Inventors: Benjamin Rosenbluth, Brian Reed, Jonathan M. Rothberg
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Patent number: D950732Type: GrantFiled: December 12, 2019Date of Patent: May 3, 2022Assignee: Tesseract Health, Inc.Inventors: Lawrence C. West, Maurizio Arienzo, Owen Kaye-Kauderer, Tyler S. Ralston, Benjamin Rosenbluth, Jonathan M. Rothberg, Jacob Coumans, Christopher Thomas McNulty
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Patent number: D950733Type: GrantFiled: December 12, 2019Date of Patent: May 3, 2022Assignee: Tesseract Health, Inc.Inventors: Lawrence C. West, Maurizio Arienzo, Owen Kaye-Kauderer, Tyler S. Ralston, Benjamin Rosenbluth, Jonathan M. Rothberg, Jacob Coumans, Christopher Thomas McNulty
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Patent number: D953535Type: GrantFiled: December 12, 2019Date of Patent: May 31, 2022Assignee: Tesseract Health, Inc.Inventors: Lawrence C. West, Maurizio Arienzo, Owen Kaye-Kauderer, Tyler S. Ralston, Benjamin Rosenbluth, Jonathan M. Rothberg, Jacob Coumans, Christopher Thomas McNulty
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Patent number: D959669Type: GrantFiled: December 12, 2019Date of Patent: August 2, 2022Assignee: Tesseract Health, Inc.Inventors: Lawrence C. West, Maurizio Arienzo, Owen Kaye-Kauderer, Tyler S. Ralston, Benjamin Rosenbluth, Jonathan M. Rothberg, Jacob Coumans, Christopher Thomas McNulty