Abstract: The present invention relates to a VHH antibody that binds to at least one fungal species and to compositions containing the same. The VHH antibody of the current invention comprises a complementarity determining region 1 (CDR1) region having the amino acid sequence set out in SEQ ID NO: 3; a CDR2 region having the amino acid sequence set out in SEQ ID NO: 4; and a CDR3 region having the amino acid sequence set out in SEQ ID NO: 5. The invention also relates to use of the composition as an anti-fungal agent. The invention further relates to agrochemical compositions and methods of using the same. Additionally, the invention relates to a transgenic plant, plant part, seed, or plant cell. The invention further relates to polynucleotides encoding said VHH antibody. Finally, the invention relates to a method of manufacturing a variant VHH antibody.

Abstract: The present invention relates to modified microbial host cells, the modification modulates protease activity of at least one endogenous protease if compared with a parent microbial host cell which lacks the modification and measured under the same or substantially the same conditions. The present invention further relates to a method of producing a compound of interest. The present invention further provides a method of increasing production of a compound of interest. The present invention further relates to a modified microbial host cell that has both a modification modulating the protease activity of at least one endogenous protease and a further modification in a regulator of transcription that regulates the transcription of one or more protease genes, resulting in a further increase in production of a compound of interest. The present invention also relates to a method of producing the modified microbial host cells of the invention.

Abstract: Compositions and methods are provided for genome modification at a target site in the genome of a filamentous fungal cell. The methods and compositions are drawn to a guide polynucleotide/Cas endonuclease system for modifying or altering the target site. Aspects in which the filamentous fungal cell being modified has a defective non-homologous end joining pathway are also provided.

Abstract: Compositions and methods are provided for genome modification at a target site in the genome of a fungal cell. The methods and compositions are drawn to a guide polynucleotide/Cas endonuclease system for promoting modification of the DNA sequence at a target site in a fungal host cell genome.

Abstract: The present compositions and methods relate to a beta-glucosidase from Glomerella graminicola, polynucleotides encoding the beta-glucosidase, and methods of making and/or use thereof. Formulations containing the beta-glucosidase may be suitable for use in hydrolyzing lignocellulosic biomass substrates.

Abstract: Compositions and methods are provided for genome modification at a target site in the genome of a filamentous fungal cell. The methods and compositions are drawn to a guide polynucleotide/Cas endonuclease system for modifying or altering the target site. Aspects in which the filamentous fungal cell being modified has a defective non-homologous end joining pathway are also provided.

Abstract: The present disclosure relates to filamentous fungal host strains and recombinant DNA constructs for creation and use thereof. The filamentous fungal host strains are particularly useful for efficiently screening DNA libraries encoding recombinant proteins.

Abstract: The present disclosure relates to cellulase variants. In particular the present disclosure relates to cellulase variants having improved expression, activity and/or stability. Also described are nucleic acids encoding the cellulase variants, compositions comprising the cellulase variants, and methods of use thereof.

Abstract: The present compositions and methods relate to a beta-glucosidase from Melanocarpus albomyces, polynucleotides encoding the beta-glucosidase, and methods of making and/or using the same. Formulations containing the beta-glucosidase are suitable for use in numerous applications, including hydrolyzing lignocellulosic biomass substrates.

Abstract: The present invention relates to filamentous fungal host cells and particularly Trichoderma host cells useful for the production of heterologous granular starch hydrolyzing enzymes having glucoamylase activity (GSHE). Further the invention relates to a method for producing a glucose syrup comprising contacting a granular starch slurry obtained from a granular starch substrate simultaneously with an alpha amylase and a GSHE at a temperature equal to or below the gelatinization temperature of the granular starch to obtain a composition of a glucose syrup.

Abstract: The present invention relates to filamentous fungal host cells and particularly Trichoderma host cells useful for the production of heterologous granular starch hydrolyzing enzymes having glucoamylase activity.

Abstract: The present invention relates to filamentous fungal host cells and particularly Trichoderma host cells useful for the production of heterologous granular starch hydrolyzing enzymes having glucoamylase activity (GSHE). Further the invention relates to a method for producing a glucose syrup comprising contacting a granular starch slurry obtained from a granular starch substrate simultaneously with an alpha amylase and a GSHE at a temperature equal to or below the gelatinization temperature of the granular starch to obtain a composition of a glucose syrup.

Abstract: The present compositions and methods relate to a beta-glucosidase from Neurospora crassa, polynucleotides encoding the beta-glucosidase, and methods of make and/or use thereof. Formulations containing the beta-glucosidase are suitable for use in hydrolyzing lignocellulosic biomass substrates.

Abstract: The present compositions and methods relate to a beta-glucosidase from Magnaporthe grisea, polynucleotides encoding the beta-glucosidase, and methods of make and/or use thereof. Formulations containing the beta-glucosidase are suitable for use in hydrolyzing lignocellulosic biomass substrates.

Abstract: The present compositions and methods relate to a beta-glucosidase from Aspergillus terreus, polynucleotides encoding the beta-glucosidase, and methods of make and/or use thereof. Formulations containing the beta-glucosidase are suitable for use in hydrolyzing lignocellulosic biomass substrates.

Abstract: The present invention relates to a polypeptide having alpha-amylase activity obtained from a strain of Aspergillus niger.

Abstract: The present invention relates to a polypeptide having alpha-amylase activity obtained from a strain of Aspergillus niger.

Abstract: The present disclosure relates to cellulase variants. In particular the present disclosure relates to cellulase variants having improved expression, activity and/or stability. Also described are nucleic acids encoding the cellulase variants, compositions comprising the cellulase variants, and methods of use thereof.

Abstract: The present invention relates to filamentous fungal host cells and particularly Trichoderma host cells useful for the production of heterologous granular starch hydrolyzing enzymes having glucoamylase activity.

Abstract: The present invention relates to filamentous fungal host cells and particularly Trichoderma host cells useful for the production of heterologous granular starch hydrolyzing enzymes having glucoamylase activity.