Abstract: Diagnosis, treatment and prophylaxis of diseases and conditions associated with smooth muscle cell (SMC) dysfunction are provided through the inhibition of IL-11-mediated signalling.

Abstract: A retention member (1) for securing a catheter (2) on a patient (P) comprises a base element (10) having a bottom side (103) and a top side (104), the bottom side being placeable on the patient (P) and the top side (104) being adapted for receiving the catheter (2). The retention member (1) furthermore comprises a ribbon (14) having a first end (140) connected to the top side (104) of the base element (10) and having a second end (141) opposite the first end (140), wherein the base element (10) comprises at least one opening (150, 151) through which the second end (141) of the ribbon (14) is insertable for fixing the catheter (2) on the retention member (1) in between the base element (10) and the ribbon (14). In this way a retention member is provided which is easy and safe to use, may suit to secure catheters of different sizes on a patient and at the same time may be manufactured in a cost-effective manner.

Abstract: An operator control apparatus, in particular for a motor vehicle, having an operating surface for manual action by an element, particularly the finger of a human hand. A sensor interacts with the operating surface such that the sensor generates a signal when the element approaches the operating surface and/or when the operating surface is touched by the element and/or when pressure is applied to the operating surface by the element. The signal is used for switching and/or triggering a function in the style of a switching signal. The actuator is operatively connected to the operating surface, such that a haptic event is producible for the operating surface by means of actuation of the actuator. The actuator is driven electrically and operable by a PWM (pulse width modulation) actuation signal, such that the operating surface is movable in a preselectable manner within a preselectable displacement and/or time.

Abstract: Provided herein is an emulsifiable concentrate comprising a triazole fungicide, an aromatic hydrocarbon, and an amide of the formula (I) as defined herein. Further provided herein is a process for the preparation of said concentrate; an emulsion obtainable by mixing water, a triazole fungicide, an aromatic hydrocarbon, and an amide of the formula (I); and a method for controlling phytopathogenic fungi, wherein the concentrate or the emulsion is allowed to act on the phytopathogenic fungi, their environment, on the crop plants to be protected from the phytopathogenic fungi or on the soil.

Abstract: A conductor transportation device for cables has a pivoting conductor conveyor. A first drive moves the conductor conveyor about a pivotal axis. The conductor conveyor has a conveyance (30a) such as, a conveyor belt running around a drive roller and a roller, together with a pressure application. A second drive is present for the. The axes of rotation of rollers (30b, c, e, f) for the conveyance and pressure application are parallel to one another and also to the pivotal axis of the conductor conveyor. A drive axis of the drive is coincident with one of the axes of rotation of the rollers. One of the axes of rotation of the rollers is coincident with the pivotal axis for the conductor conveyor. The actuation paths of the pivotal axis and the conveyor roller or the driven roller are spaced apart.

Abstract: The present invention relates to a cartridge for a drug delivery device comprising of a body of substantially cylindrical shape, a piston slidably disposed in the body along two opposite axial directions, along a distal and along a proximal direction, and at least one friction means operably engaged with the piston to generate a pre-defined friction force between the piston and an inside wall of the body, when the piston is displaced relative to the body, wherein in response to an axial displacement of the piston relative to the body in distal direction and in proximal direction, the at least one friction means is adapted to generate respective proximal and distal friction forces that are different in magnitude.

Abstract: The present invention relates to a cartridge for a drug delivery device comprising of a body of substantially cylindrical shape, a piston slidably disposed in the body along two opposite axial directions, along a distal and along a proximal direction, and at least one friction means operably engaged with the piston to generate a pre-defined friction force between the piston and an inside wall of the body, when the piston is displaced relative to the body, wherein in response to an axial displacement of the piston relative to the body in distal direction and in proximal direction, the at least one friction means is adapted to generate respective proximal and distal friction forces that are different in magnitude.

Abstract: The present invention relates to a drive mechanism for a drug delivery device for dispensing of a dose of a medicinal product, comprising: a holder for a product-containing cartridge, the cartridge having a piston slidably arranged therein in an axial direction, a piston rod to be operably engaged with the cartridge's piston for dispensing of a dose of the medicinal product, an adjusting assembly adapted to eliminate axial clearance between the piston and the piston rod, wherein the adjusting assembly comprises at least one radially extending spike element for mutually locking in position the piston and the piston rod irrespective of the relative distance between piston and piston rod.

Abstract: The present invention relates to a drug delivery device for dispensing of a predefined dose of a medicinal product, comprising: a housing, a cartridge holder adapted to receive a cartridge containing the medicinal product to be dispensed, the cartridge holder being connectable to the housing, a drive mechanism to be operably engaged with the cartridge for setting and/or dispensing of a predefined dose of the medicinal product, wherein the drive mechanism is axially slidingly supported in the housing for compensating axial clearance between the drive mechanism and the cartridge and wherein the drive mechanism is axially fixable relative to the housing.

Abstract: A method and system for generating a test bench for testing a requirement is described. According to an embodiment, a test bench generator subsystem automatically chooses a test template based on a user specification of a requirement to be tested. The requirement is automatically associated with information such as parameters, context identifiers, and success criteria. The subsystem automatically generates a test bench data construct for a simulation that will test the requirement and evaluate success or failure. In an embodiment, generating the test bench includes automatically choosing a system model for the test bench.

Abstract: Melamine derivatives and mixtures thereof with aqueous systems, a process for inhibiting corrosion of metals and metal alloys with melamine derivatives and mixtures thereof and the use of melamine derivatives and mixtures thereof as corrosion inhibitors for aqueous systems, for example water/oil mixtures, especially in the field of cleaning compositions, cooling fluids, oilfield chemicals or lubricants.

Abstract: A drug delivery device for dispensing of a dose of a medicinal product is presented comprising a first housing component having a receptacle being oval- or elliptically shaped in radial cross section and being adapted to at least partially receive an insert portion of a second housing component being at least partially insertable into said first housing component along an axial direction, wherein the insert portion is oval- or elliptically shaped in radial cross section. The outside dimension or an at least one outside diameter of the insert portion is at least in sections larger than a corresponding inner dimension or an at least one inner diameter of the receptacle and wherein the insert portion and the receptacle are adapted to generate a radially acting mutual clamping of first and second housing components in a pre-fixing assembly configuration.

Abstract: The present invention relates to a drive mechanism for a drug delivery device for dispensing of a dose of a medicinal product, comprising: a holder for a product-containing cartridge, the cartridge having a piston slidably arranged therein in an axial direction, a piston rod to be operably engaged with the cartridge's piston for dispensing of a dose of the medicinal product, an adjusting assembly adapted to eliminate axial clearance between the piston and the piston rod, wherein the adjusting assembly comprises at least one radially extending spike element for mutually locking in position the piston and the piston rod irrespective of the relative distance between piston and piston rod.

Abstract: The present invention relates to a drug delivery device for dispensing of a predefined dose of a medicinal product, comprising: a housing, a cartridge holder adapted to receive a cartridge containing the medicinal product to be dispensed, the cartridge holder being connectable to the housing, a drive mechanism to be operably engaged with the cartridge for setting and/or dispensing of a predefined dose of the medicinal product, wherein the drive mechanism is axially slidingly supported in the housing for compensating axial clearance between the drive mechanism and the cartridge and wherein the drive mechanism is axially fixable relative to the housing.

Abstract: The present invention relates to a drive mechanism for a drug delivery device as well as to a drug delivery device for dispensing of a dose of a medicinal product, wherein the drive mechanism comprises: a holder for a product-containing cartridge, the cartridge having a piston slidably arranged therein in an axial direction, a piston rod to be operably engaged with the cartridge's piston for dispensing of a dose of the medicinal product, at least one adjusting member slidably arranged in axial direction relative to the piston and/or relative to the piston rod for eliminating axial clearance between the piston and the piston rod, an interlock means adapted to interact with the adjusting member for mutually locking in position the piston and the piston rod irrespective of the relative distance between piston and piston rod.

Abstract: A method and system for publishing an online post from a device that includes obtaining information for a post and receiving user input from a single-interaction interface on the device. The received user input initiates selecting a context descriptor for the post based on the user input; creating the post from the obtained information and selected context descriptor, and sending the post to a post database.

Abstract: A method and system for informing a user by utilizing time based reviews that include collecting a plurality of user reviews. A user review includes business information, a user opinion that includes at least a rating, and time information that relates to the time of user interaction with the business. The method further includes extracting information from the plurality of user reviews based on the interaction time and presenting the extracted information to a user.