Abstract: Described herein are engineered multilayered vascular tubes comprising at least one layer of differentiated adult fibroblasts, at least one layer of differentiated adult smooth muscle cells, wherein any layer further comprises differentiated adult endothelial cells, wherein said tubes have the following features: (a) a ratio of endothelial cells to smooth muscle cells of about 1:99 to about 45:55; (b) the tube is compliant; (c) the internal diameter of the tube is about 6 mm or smaller; (d) the length of the tube is up to about 30 cm; and (e) the thickness of the tube is substantially uniform along a region of the tube; provided that the engineered multilayered vascular tube is free of any pre-formed scaffold. Also described herein are methods of forming said tubes and uses for said tubes including methods for treating patients, comprising providing such a tube into to a patient in need thereof.

Abstract: Disclosed are living, three-dimensional tissue constructs for in vitro scientific and medical research, arrays thereof, and methods of making said tissues and arrays.

Abstract: Disclosed are engineered tissues and organs comprising one or more layers of muscle, the engineered tissue or organ consisting essentially of cellular material, provided that the engineered tissue or organ is implantable in a vertebrate subject and not a vascular tube.

Abstract: Described herein are engineered multilayered vascular tubes comprising at least one layer of differentiated adult fibroblasts, at least one layer of differentiated adult smooth muscle cells, wherein any layer further comprises differentiated adult endothelial cells, wherein said tubes have the following features: (a) a ratio of endothelial cells to smooth muscle cells of about 1:99 to about 45:55; (b) the tube is compliant; (c) the internal diameter of the tube is about 6 mm or smaller; (d) the length of the tube is up to about 30 cm; and (e) the thickness of the tube is substantially uniform along a region of the tube; provided that the engineered multilayered vascular tube is free of any pre-formed scaffold. Also described herein are methods of forming said tubes and uses for said tubes including methods for treating patients, comprising providing such a tube into to a patient in need thereof.

Abstract: A bleeding device (1, 100) for bleeding air from a hydraulic system, which includes a bleed screw (2, 102) and a bleeding needle (3, 103) for unseating the bleed screw (2, 102) to enable any air trapped within the system to be bled. The bleed screw (2, 102) is receivable within a threaded bleed port (41) in a component of the system, such as a brake caliper (4). The bleed screw (2, 102) includes a socket (28, 128), a conical sealing face (27) and a radial fluid passage (24) between the sealing face (27) and the socket (28, 128). The bleed needle (3, 103) includes a plug (34, 134) for releasable engaging receipt within the socket (28, 128) of the valve member and a fluid passageway (31) which is in fluid communication with the radial fluid passage (24) of the bleed screw (2) when the plug (34, 134) is received within the socket (28, 128).

Abstract: A brake caliper (1) including a caliper body (2) with a pair of spaced limbs (3), a pair of end bridging members (4) each joining together a respective end of each limb (3) and an intermediate bridging portion (5) between the bridging members (4) and joining together a respective intermediate portion of each limb (3). Each limb (3) includes a hydraulic circuit (30) including fluidly connected hydraulic cylinders (31a, 31b, 31c) within which respective pistons (6a, 6b, 6c) are received. The hydraulic circuits (30) are fluidly connected together by a fluid channel (7). Part of the fluid channel (7) is formed in the intermediate bridging portion (5) and extends diagonally across the space between the limbs (3) and between the bridging members (4).

Abstract: A brake caliper (100) with first and second parts (104a, 104b) between which is received a pair of braking members (102a, 102b). The caliper (100) includes a service brake mechanism having at least two piston and cylinder assemblies (108a, 110a and 108b, 110b) forming an opposed piston mechanism for forcing each of the braking members (102a, 102b) towards a brake disc to apply a service braking force thereto. The caliper (100) also includes a park brake mechanism including an actuator mechanism (112) for applying a driving force to a first opposed braking member (102a) towards the brake disc and a force transmitting member (116) for transmitting the driving force to a second opposed braking member (102b).

Abstract: A method comprises receiving, by a provider computing system from a customer computing system, a transaction request for processing a transaction. The transaction includes a transaction information. The provider computing system determines that the transaction information is complete transaction information. The provider computing system determines a transaction history associated with a party to the transaction request. A portion of the transaction history is not accessible by the customer computing system. The provider computing system determines a possible instance of fraud based on the transaction history and the complete transaction information. The provider computing system generates a UAR. Furthermore, the provider computing system populates a blank field of the UAR, based on the analysis of the transaction history with the complete transaction information.

Abstract: A bleeding device (1, 100) for bleeding air from a hydraulic system, which includes a bleed screw (2, 102) and a bleeding needle (3, 103) for unseating the bleed screw (2, 102) to enable any air trapped within the system to be bled. The bleed screw (2, 102) is receivable within a threaded bleed port (41) in a component of the system, such as a brake caliper (4). The bleed screw (2, 102) includes a socket (28, 128), a conical sealing face (27) and a radial fluid passage (24) between the sealing face (27) and the socket (28, 128). The bleed needle (3, 103) includes a plug (34, 134) for releasable engaging receipt within the socket (28, 128) of the valve member and a fluid passageway (31) which is in fluid communication with the radial fluid passage (24) of the bleed screw (2) when the plug (34, 134) is received within the socket (28, 128).

Abstract: A brake caliper (1) including a caliper body (2) with a pair of spaced limbs (3), a pair of end bridging members (4) each joining together a respective end of each limb (3) and an intermediate bridging portion (5) between the bridging members (4) and joining together a respective intermediate portion of each limb (3). Each limb (3) includes a hydraulic circuit (30) including fluidly connected hydraulic cylinders (31a, 31b, 31c) within which respective pistons (6a, 6b, 6c) are received. The hydraulic circuits (30) are fluidly connected together by a fluid channel (7). Part of the fluid channel (7) is formed in the intermediate bridging portion (5) and extends diagonally across the space between the limbs (3) and between the bridging members(4).

Abstract: Disclosed are living, three-dimensional tissue constructs for in vitro scientific and medical research, arrays thereof, and methods of making said tissues and arrays.

Abstract: A brake caliper (100) with first and second parts (104a, 104b) between which is received a pair of braking members (102a, 102b). The caliper (100) includes a service brake mechanism having at least two piston and cylinder assemblies (108a, 110a and 108b, 110b) forming an opposed piston mechanism for forcing each of the braking members (102a, 102b) towards a brake disc to apply a service braking force thereto. The caliper (100) also includes a park brake mechanism including an actuator mechanism (112) for applying a driving force to a first opposed braking member (102a) towards the brake disc and a force transmitting member (116) for transmitting the driving force to a second opposed braking member (102b).

Abstract: Described herein are engineered multilayered vascular tubes comprising at least one layer of differentiated adult fibroblasts, at least one layer of differentiated adult smooth muscle cells, wherein any layer further comprises differentiated adult endothelial cells, wherein said tubes have the following features: (a) a ratio of endothelial cells to smooth muscle cells of about 1:99 to about 45:55; (b) the tube is compliant; (c) the internal diameter of the tube is about 6 mm or smaller; (d) the length of the tube is up to about 30 cm; and (e) the thickness of the tube is substantially uniform along a region of the tube; provided that the engineered multilayered vascular tube is free of any pre-formed scaffold. Also described herein are methods of forming said tubes and uses for said tubes including methods for treating patients, comprising providing such a tube into to a patient in need thereof.

Abstract: Disclosed are living, three-dimensional tissue constructs for in vitro scientific and medical research, arrays thereof, and methods of making said tissues and arrays.

Abstract: Disclosed are engineered tissues and organs comprising one or more muscle cell-containing layers, the engineered tissue or organ consisting essentially of cellular material, provided that the engineered tissue or organ is implantable in a vertebrate subject and not a vascular tube.

Abstract: This application discloses methods and materials for preparing functional microvascular beds in the laboratory. These prevascularized constructs can be used to vascularize engineered tissue constructs or to revascularize damaged or diseased tissues or organs following implantation. The prevascularized constructs may also deliver genetically engineered gene products to the bloodstream.

Abstract: A control system for a cooling fan of a laser printer that enables selection of a multitude of varying fan speeds based on the actual degree of usage of the printer.

Abstract: An improved variable speed fan controller for use in devices such as laser printers. The controller automatically adjusts its output signal to fans such that a fan quickly settles into an appropriate operating speed, even if the fan has been newly installed into the equipment. The controller can store values in non-volatile memory, if desired, to keep track of recent changes in the fan's operating parameters and corresponding control signal values. The controller is able to control relatively inexpensive fans that don't necessarily operate at a predictable fan rotating speed under repeatable conditions and control signals, by controlling the fan to an initial or predetermined rotating speed; if the fan isn't running within a suitable range of rotational speeds, then determining whether a fine or coarse adjustment should be made to the fan's rotational speed. The controller makes appropriate adjustments until the fan's rotational speed is within acceptable operating tolerances.