Abstract: A refractory unit for lining a high temperature vessel includes a refractory body formed from a refractory material. The refractory body has an upper main surface, a lower main surface, an inner surface configurable to face a high temperature chamber, an outer surface configurable to face away from the high temperature chamber, a first side surface and a second side surface. An elastic member is attached to the outer surface.

Abstract: A refractory unit for lining a high temperature vessel includes a refractory body formed from a refractory material. The refractory body has an upper main surface, a lower main surface, an inner surface configurable to face a high temperature chamber, an outer surface configurable to face away from the high temperature chamber, a first side surface and a second side surface. An elastic member is attached to the outer surface.

Abstract: A method of identifying a plurality of regions in a genome that bind to PAX3-FOXO1 is described. The method includes the steps of obtaining chromatin from a cell; sonicating the chromatin; isolating the chromatin by immunoprecipitation using an antibody that binds to FOXO1, purifying the DNA from the immunoprecipitated chromatin; amplifying and sequencing the DNA; and analyzing the sequenced DNA to identify the regions in the genome of the cell that bind to PAX3-FOXO1. A method of treating a subject having rhabdomyosarcoma by modulating the expression of a genomic region of a cancer cell identified by the method is also described.

Abstract: The present invention relates to macrocyclic small molecule inhibitors of the Sonic Hedgehog signaling pathway, syntheses thereof, and intermediates thereto. Such small molecule modulators of the Sonic Hedgehog signaling pathway are useful in the treatment of proliferative diseases (e.g., basal cell carcinoma, Gorlin syndrome, medulloblastoma, or pancreatic cancer), pulmonary diseases (e.g., interstitial pnuemonitis or interstitial pulmonary fibrosis), and developmental disorders (e.g., phocomelia or cyclopia). Novel non-natural macrocycles are provided that inhibit Sonic Hedgehog induced-protein transcription.

Abstract: The present invention relates to relates to macrocyclic small molecule inhibitors of the Sonic Hedgehog signaling pathway, syntheses thereof, and intermediates thereto. Such small molecule modulators of the Sonic Hedgehog signaling pathway are useful in the treatment of proliferative diseases (e.g., basal cell carcinoma, Gorlin syndrome, medulloblastoma, or pancreatic cancer), pulmonary diseases (e.g., interstitial pnuemonitis or interstitial pulmonary fibrosis), and developmental disorders (e.g., phocomelia or cyclopia). Novel non-natural macrocycles are provided that inhibit Sonic Hedgehog induced-protein transcription.