Abstract: A conduit coupling device is provided for enabling a conduit coupling system and method. The conduit coupling device has two portions, a coupler and a cap, that adhere, respectively, to two separate conduits being coupled together. The coupler has a first tubular end and a second end that provides an arcuate cutout. The coupler provides an adhesive channel along the arcuate cutout. The inner surfaces of two ends engage outer surfaces of the two separate conduits, respectively. The cap is dimensioned and adapted to adhere to a portion of the outer surface of the second arcuate cutout conduit so as to provide an adhesive ridge there along. The adhesive ridge is dimensioned to be slidably received in the adhesive channel, thereby forming a locked engagement between the first and second conduits.

Abstract: A conduit coupling device is provided for enabling a conduit coupling system and method. The conduit coupling device has two portions, a coupler and a cap, that adhere, respectively, to two separate conduits being coupled together. The coupler has a first tubular end and a second end that provides an arcuate cutout. The coupler provides a glue channel along the arcuate cutout. The inner surfaces of two ends engage outer surfaces of the two separate conduits, respectively. The cap is dimensioned and adapted to adhere to a portion of the outer surface of the second arcuate cutout conduit so as to provide a glue ridge there along. The glue ridge is dimensioned to be slidably received in the glue channel, thereby forming a locked engagement between the first and second conduits.

Abstract: A tissue sample that has been removed from a subject can be evaluated. A change in speed of the energy traveling through the sample is evaluated to monitor changes in the biological sample during processing. The monitoring can detect movement of fluid with the sample and cross-linking. A system for performing the method can include a transmitter that outputs the energy and a receiver configured to detect the transmitted energy.

Abstract: A conduit coupling device is provided for enabling a conduit coupling system and method. The conduit coupling device has two portions, a coupler and a cap, that adhere, respectively, to two separate conduits being coupled together. The coupler has a first tubular end and a second end that provides an arcuate cutout. The coupler provides a glue channel along the arcuate cutout. The inner surfaces of two ends engage outer surfaces of the two separate conduits, respectively. The cap is dimensioned and adapted to adhere to a portion of the outer surface of the second arcuate cutout conduit so as to provide a glue ridge there along. The glue ridge is dimensioned to be slidably received in the glue channel, thereby forming a locked engagement between the first and second conduits.

Abstract: The subject disclosure presents systems and computer-implemented methods for determining an acoustic time-of-flight (TOF) of sound waves through a sample material with greater accuracy and in a more repeatable fashion, by invoking one or more of an envelope generation for an error function, fitting a non-linear curve to an ultrasound frequency sweep, or performing a clustered piece-wise linear regression on individual linear parts of the ultrasonic frequency sweep. The systems and methods are useful for, among other things, monitoring diffusion of fluids through porous materials, such as tissue samples.

Abstract: A tissue sample that has been removed from a subject can be evaluated. A change in speed of the energy traveling through the sample is evaluated to monitor changes in the biological sample during processing. The monitoring can detect movement of fluid with the sample and cross-linking. A system for performing the method can include a transmitter that outputs the energy and a receiver configured to detect the transmitted energy.

Abstract: An electrochemical-cell stack assembly is provided. The assembly has an electrochemical-cell stack and a compression system that holds the electrochemical-cell stack in a state of compression. The compression system has a first endplate and a second endplate positioned at opposite ends of the electrochemical-cell stack. The compression system has a set of tension members coupled to the first endplate and the second endplate that maintain a fixed distance between the first endplate and the second endplate. The compression system has a compression plate disposed between the second endplate and the electrochemical-cell stack. The compression system has a compression member in contact with the compression plate, wherein the compression member is configured to transfer a force to the compression plate. The compression system has a locking nut fastened to the second plate. The locking nut secures the position of the compression member and compression plate relative to the second endplate.

Abstract: An electrochemical-cell stack assembly is provided. The assembly has an electrochemical-cell stack and a compression system that holds the electrochemical-cell stack in a state of compression. The compression system has a first endplate and a second endplate positioned at opposite ends of the electrochemical-cell stack. The compression system has a set of tension members coupled to the first endplate and the second endplate that maintain a fixed distance between the first endplate and the second endplate. The compression system has a compression plate disposed between the second endplate and the electrochemical-cell stack. The compression system has a compression member in contact with the compression plate, wherein the compression member is configured to transfer a force to the compression plate. The compression system has a locking nut fastened to the second plate. The locking nut secures the position of the compression member and compression plate relative to the second endplate.

Abstract: Methods, systems, and apparatuses for detecting and describing heterogeneity in a cell sample are disclosed herein. A plurality of fields of view (FOV) are generated for one or more areas of interest (AOI) within an image of the cell sample are generated. Hyperspectral or multispectral data from each FOV is organized into an image stack containing one or more z-layers, with each z-layer containing intensity data for a single marker at each pixel in the FOV. A cluster analysis is applied to the image stacks, wherein the clustering algorithm groups pixels having a similar ratio of detectable marker intensity across layers of the z-axis, thereby generating a plurality of clusters having similar expression patterns.

Abstract: Systems and methods for presenting CRM data. Users may configure what to display on a custom report and how to arrange and display the content (e.g., size, color, theme), so that they can visualize the CRM data the way they want. A data visualization interface may be used to generate the custom report, and may use HTML to specify the CRM data to be displayed and their location on the custom report according to user configuration. The data visualization interface may use JavaScript for specifying the objects and fields users want to query to obtain the CRM data to fill up the custom report. An API may communicate with the JavaScript in the data visualization interface and then query data and objects in the CRM to get a result set. The API may be a unified API which may work across multiple platforms and query various types of database, e.g., iOS, Windows, and the browser for Salesforce online. Users may edit the CRM data displayed in the custom report.

Abstract: Methods, systems, and apparatuses for detecting and describing heterogeneity in a cell sample are disclosed herein. A plurality of fields of view (FOV) are generated for one or more areas of interest (AOI) within an image of the cell sample are generated. Hyperspectral or multispectral data from each FOV is organized into an image stack containing one or more z-layers, with each z-layer containing intensity data for a single marker at each pixel in the FOV. A cluster analysis is applied to the image stacks, wherein the clustering algorithm groups pixels having a similar ratio of detectable marker intensity across layers of the z-axis, thereby generating a plurality of clusters having similar expression patterns.

Abstract: In some embodiments, an apparatus includes providing a representation of a set of digital medical images to a first machine learning model to define a feature vector associated with a presence of an intracranial hemorrhage. A representation of the set of digital medical images is provided to a second machine learning model to define a second feature vector associated with a volume of the intracranial hemorrhage. Using a third machine learning model, a set of EMRs associated with risk factors for a predefined indication is analyzed to define a third feature vector. The first, second and third feature vectors are provided as inputs to a fourth machine learning model to determine a metric associated with an applicability of a specific treatment associated with a predefined indication. An alert is sent to relevant healthcare providers and relevant tests, procedures or bloodwork are ordered for the predefined indication.

Abstract: A tissue sample that has been removed from a subject can be properly fixed for evaluation using the disclosed transporter assembly for carrying a tissue sample and method for fixing an unfixed tissue sample. In one embodiment, the disclosed assembly includes a transport container, a fixative in the transport container, and a cooling device that reduces and/or maintains the temperature of the fixative to perform a pre-soaking process at a temperature of less than about 7° C. The pre-soaking process can, for example, be performed during sample transport or during extended periods of storage, such as over a weekend.

Abstract: Methods, systems, and apparatuses for detecting and describing heterogeneity in a cell sample are disclosed herein. A plurality of fields of view (FOV) are generated for one or more areas of interest (AOI) within an image of the cell sample are generated. Hyperspectral or multispectral data from each FOV is organized into an image stack containing one or more z-layers, with each z-layer containing intensity data for a single marker at each pixel in the FOV. A cluster analysis is applied to the image stacks, wherein the clustering algorithm groups pixels having a similar ratio of detectable marker intensity across layers of the z-axis, thereby generating a plurality of clusters having similar expression patterns.

Abstract: The subject disclosure presents systems and computer-implemented methods for determining an acoustic time-of-flight (TOF) of sound waves through a sample material with greater accuracy and in a more repeatable fashion, by invoking one or more of an envelope generation for an error function, fitting a non-linear curve to an ultrasound frequency sweep, or performing a clustered piece-wise linear regression on individual linear parts of the ultrasonic frequency sweep. The systems and methods are useful for, among other things, monitoring diffusion of fluids through porous materials, such as tissue samples.

Abstract: A tissue sample that has been removed from a subject can be properly fixed for evaluation using the disclosed transporter assembly for carrying a tissue sample and method for fixing an unfixed tissue sample. In one embodiment, the disclosed assembly includes a transport container, a fixative in the transport container, and a cooling device that reduces and/or maintains the temperature of the fixative to perform a pre-soaking process at a temperature of less than about 7° C. The pre-soaking process can, for example, be performed during sample transport or during extended periods of storage, such as over a weekend.

Abstract: Methods, systems, and apparatuses for detecting and describing heterogeneity in a cell sample are disclosed herein. A plurality of fields of view (FOV) are generated for one or more areas of interest (AOI) within an image of the cell sample are generated. Hyperspectral or multispectral data from each FOV is organized into an image stack containing one or more z-layers, with each z-layer containing intensity data for a single marker at each pixel in the FOV. A cluster analysis is applied to the image stacks, wherein the clustering algorithm groups pixels having a similar ratio of detectable marker intensity across layers of the z-axis, thereby generating a plurality of clusters having similar expression patterns.

Abstract: The subject disclosure presents systems and computer-implemented methods for determining an acoustic time-of-flight (TOF) of sound waves through a sample material with greater accuracy and in a more repeatable fashion, by invoking one or more of an envelope generation for an error function, fitting a non-linear curve to an ultrasound frequency sweep, or performing a clustered piece-wise linear regression on individual linear parts of the ultrasonic frequency sweep. The systems and methods are useful for, among other things, monitoring diffusion of fluids through porous materials, such as tissue samples.

Abstract: The subject disclosure presents systems and computer-implemented methods for calculating the diffusivity constant of a sample using acoustic time-of-flight (TOF) based information correlated with a diffusion model to reconstruct a sample's diffusivity coefficient. Operations disclosed herein such as acoustically determining the phase differential accumulated through passive fluid exchange (i.e. diffusion) based on the geometry of the tissue sample, modeling the impact of the diffusion on the TOF, and using a post-processing algorithm to correlate the results to determine the diffusivity constant, are enabled by monitoring the changes in the speed of sound caused by penetration of fixative such as formalin into several tissue samples. A tissue preparation system may be adapted to monitor said diffusion of a tissue sample and determine an optimal processing workflow.