Abstract: A method for the construction of a habitable structure. The method including the receiving of a module consisting of four walls, a ceiling, and a floor. Next the method requires the reviewing of a set of shop drawings to determine the required modifications to the module to fabricate at least one bathroom and a kitchen within the interior of the module. The method requires installing framing, plumbing and electrical consistent with the shop drawings and then transferring the module to a job site where it is attached to a pad or a foundation. Next the method requires the constructing of additional living space around the footprint of the module and within the perimeter of the at least one of the pad or the foundation.

Abstract: The disclosed embodiments include a calorie optimization respiratory exchange fat macro utilization metabolic system, comprising a computer-readable storage media having stored thereon computer-executable instructions; a processor for executing the computer-executable instructions, wherein the computer-executable instructions include instructions for receiving user profile data from a user, wherein the user profile data includes age, sex, height, weight, diet, fitness information; and if available, five specific metabolic data points from individual respiratory exchange testing; otherwise, calculating five specific metabolic points versus heart rate; generating an individualized metabolic profile for the user based on the five metabolic points; determining for the user an individualized target exercise heart rate zone as a percentage of maximum heart rate from the metabolic profile, and determining a nutritional guideline from the metabolic profile, measuring user compliance to facilitate machine learning pro

Abstract: The disclosed embodiments include a calorie optimization respiratory exchange metabolic system comprising a computer-readable storage media having stored thereon computer-executable instructions; a processor for executing the computer-executable instructions, wherein the computer-executable instructions include instructions for receiving user profile data of a user, wherein the user profile data includes age, height, weight, diet, and fitness information; determining five metabolic points versus heart rate; generating an individualized metabolic profile for the user based on the five metabolic points; determining for the user an individualized nutritional guideline from the metabolic profile, wherein the individualized nutritional guideline is determined by percent fat, percent protein and percent carbohydrate to optimize fat metabolism for weight loss, maintenance, and endurance exercise enhancement; and determining an individualized exercise heart rate profile as a percentage of maximum heart rate from the

Abstract: The disclosed embodiments include a calorie optimization respiratory exchange fat macro utilization metabolic system, comprising a computer-readable storage media having stored thereon computer-executable instructions; a processor for executing the computer-executable instructions, wherein the computer-executable instructions include instructions for receiving user profile data from a user, wherein the user profile data includes age, sex, height, weight, diet, fitness information; and if available, five specific metabolic data points from individual respiratory exchange testing; otherwise, calculating five specific metabolic points versus heart rate; generating an individualized metabolic profile for the user based on the five metabolic points; determining for the user an individualized target exercise heart rate zone as a percentage of maximum heart rate from the metabolic profile, and determining a nutritional guideline from the metabolic profile, measuring user compliance to facilitate machine learning pro

Abstract: Acoustical materials of the type provided in panel form for purposes of controlling or adjusting the acoustics of an interior space, such as an auditorium or concert hall, conference room, etc., and commonly referred to as architectural acoustical panels or ceiling panels. A panel comprises multiple layers, such as a surface layer which faces the room or sound source, which in turn comprises wood veneer laminated to a supporting layer and defines a plurality of microperforations extending entirely through, the surface layer. An acoustical absorbing layer may be a wood wool material or, most preferably, high-density fiberglass having a particular orientation, along with a combination of a support material or ribbing, which may define a plurality of cells in which the fiberglass lies. A back support layer may be perforated or solid.

Abstract: The invention provides isolated nucleic acids molecules, designated UBA3, UAE, or UBA6, or other E1 enzyme variant nucleic acid molecules, which encode novel E1 enzyme variant proteins. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing UBA3, UAE, or UBA6, or other E1 enzyme variant nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a UBA3, UAE, or UBA6, or other E1 enzyme variant gene has been introduced or disrupted. The invention still further provides isolated UBA3, UAE, or UBA6, or other E1 enzyme variant proteins, fusion proteins, antigenic peptides and anti-UBA3, UAE, or UBA6, or other E1 enzyme variant antibodies. The invention provides methods to identify agents that inhibit UBA3, UAE, or UBA6, or other E1 enzyme variant expression or activity. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.

Abstract: Disclosed are chemical entities that inhibit Uba6, each of which is a compound of Formula (I) or a pharmaceutically acceptable salt thereof, wherein R*1 is —H or —CH3; and Y is Formula (II) or Formula (III), wherein R2 is —H, —CH3 or C1-4 alkyloxycarbonyl; and RS7.1, RS7.2 and RS8.1 are defined herein; pharmaceutical compositions comprising the chemical entities; and methods of using the chemical entities. These chemical entities are useful for treating disorders, particularly cell proliferation disorders, including cancers.

Abstract: The disclosed embodiments include a calorie optimization respiratory exchange metabolic system comprising a computer-readable storage media having stored thereon computer-executable instructions; a processor for executing the computer-executable instructions, wherein the computer-executable instructions include instructions for receiving user profile data of a user, wherein the user profile data includes age, height, weight, diet, and fitness information; determining five metabolic points versus heart rate; generating an individualized metabolic profile for the user based on the five metabolic points; determining for the user an individualized nutritional guideline from the metabolic profile, wherein the individualized nutritional guideline is determined by percent fat, percent protein and percent carbohydrate to optimize fat metabolism for weight loss, maintenance, and endurance exercise enhancement; and determining an individualized exercise heart rate profile as a percentage of maximum heart rate from the

Abstract: Disclosed are chemical entities that inhibit Uba6, each of which is a compound of Formula /: Formula (I) or a pharmaceutically acceptable salt thereof, wherein R*1 is —H or —CH3; and Y is Formula (II) or Formula (III), wherein R2 is —H, —CH3 or C1-4 alkyloxycarbonyl; and RS7.1, RS7.2 and RS8.1 are defined herein; pharmaceutical compositions comprising the chemical entities; and methods of using the chemical entities. These chemical entities are useful for treating disorders, particularly cell proliferation disorders, including cancers.

Abstract: The invention provides isolated nucleic acids molecules, designated UBA3, UAE, or UBA6, or other E1 enzyme variant nucleic acid molecules, which encode novel E1 enzyme variant proteins. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing UBA3, UAE, or UBA6, or other E1 enzyme variant nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a UBA3, UAE, or UBA6, or other E1 enzyme variant gene has been introduced or disrupted. The invention still further provides isolated UBA3, UAE, or UBA6, or other E1 enzyme variant proteins, fusion proteins, antigenic peptides and anti-UBA3, UAE, or UBA6, or other E1 enzyme variant antibodies. The invention provides methods to identify agents that inhibit UBA3, UAE, or UBA6, or other E1 enzyme variant expression or activity. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.

Abstract: A hand-held ultrasonic imaging apparatus having an integrated display and transducer. The transducer and display are relatively configured so that an operator may look directly down at the patient and, at the same time visualize images of the patient's internal body structures on the display. The apparatus may be used to facilitate placement and insertion of a needle or catheter into a patient. Images displayed on the screen (e.g., the tip of the needle or catheter and an intended internal target body structure) and the actual needle or catheter itself may be maintained within the same visual axis of the operator, thereby avoiding any need to look away from the needle or catheter in order to visualize images on the display. The apparatus may also include an integrated transducer control and signal processing circuit, which together with the integrated display and transducer, provide a complete integrated ultrasonic imaging solution.

Abstract: A rotational power transfer device includes a rotatable shaft, a plurality of arm structures attached to the shaft and extending radially outward from the shaft, a plurality of panel members attached to the arm structures and hanging downward therefrom, and an energy converting member for converting energy to electricity. Another vertical turbine is includes a rotatably driven power maker using panel members connected to a drive shaft such that the panel members are laterally disposed from the drive shaft in a spaced relation therefrom. A wind power generation system includes a turbine and roof top wind collector.

Abstract: Disclosed is a yeast cell whose genetic complement includes an inactive allele of the yeast CDC7 gene, a first nucleic acid that encodes a mammalian Cdc7 protein, and a second nucleic acid that encodes a mammalian Dbf4 protein. The yeast cell is dependent on the mammalian Cdc7 and Dbf4 proteins for viability. The yeast cell can be used to identify potential anti-proliferative agents by virtue of their inhibition of the mammalian Cdc7 and Dbf4 proteins. In some embodiments, a control yeast cell which does not depend on Cdc7 for viability is used in a secondary screen.

Abstract: Disclosed is a yeast cell whose genetic complement includes an inactive allele of the yeast CDC7 gene, a first nucleic acid that encodes a mammalian Cdc7 protein, and a second nucleic acid that encodes a mammalian Dbf4 protein. The yeast cell is dependent on the mammalian Cdc7 and Dbf4 proteins for viability. The yeast cell can be used to identify potential anti-proliferative agents by virtue of their inhibition of the mammalian Cdc7 and Dbf4 proteins. In some embodiments, a control yeast cell which does not depend on Cdc7 for viability is used in a secondary screen.

Abstract: Disclosed are Candida albicans kinase genes and polypeptides and their use in identifying antifungal agents, for example.