Abstract: The present disclosure relates to methods for modulating (e.g., maintaining) pluripotency and self-renewal property of cells (e.g., stem cells) by blocking the non-canonical tricarboxylic acid (TCA) cycle (e.g. using an inhibitor of ATP citrate lyase (ACL) or acetate), and kits and compositions relating thereto.

Abstract: One embodiment of the present invention enables an individual to selectively choose an area(s) of interest and automatically scan a database to intelligently retrieve the relevant information and filter out the irrelevant information. Next, the relevant information may then be collated and made available in an electronic “book” format for ease of distribution. For example, a network administrator may go to his/her company's web page and utilize the present embodiment to download an electronic “book” pertaining to troubleshooting his/her particular network configuration. It is appreciated that the present embodiment may be utilized in a broad number of different areas since it covers any application where there may be a huge database of information and only a part of which may be of interest to selected parties. For example, the present embodiment may be quite useful in areas such as, but not limited to, pharmaceutical, manufacturing, medical, defense, and computer networking.