Abstract: The present invention belongs to the field of pharmaceutical formulations, and relates to a composition comprising a derivative of a wild-type cell-penetrating peptide penetratin and a drug having positive charge under physiological pH conditions. The derivative of the wild-type cell-penetrating peptide penetratin is a lipophilic derivative designed by using the wild-type cell-penetrating peptide penetratin, and the molecule is positively charged as a whole under physiological pH conditions. Said composition of the present invention, as an ocular drug delivery system, can enable a drug positively charged under physiological pH conditions to be absorbed to the posterior segment of the eye by means of eye dropping, thereby providing a new route for achieving ocular delivery of a drug positively charged under physiological pH conditions.

Abstract: The present invention relates to pharmaceutical compositions of ramelteon and methods of use thereof. More specifically, the present invention relates to pharmaceutical compositions of ramelteon for use in the treatment of insomnia and jet lag by transmucosal administration. The present invention achieved faster onset of pharmacological effects by delivery of low dosage of ramelteon via intranasal or sublingual routes, as compared to conventional oral tablet administration.

Abstract: Sprayable aqueous pharmaceutical compositions containing granisetron or a pharmaceutically salt thereof, and pharmaceutically acceptable inactive ingredients, including tonicity agents, preservatives, and water soluble polymers with bioadhesive properties and/or capable of changing the rheological behavior in relation to ions, pH and temperature. The compositions are intranasally administered to a subject in need thereof in the rapid management and or prevention of nausea and/or vomiting induced by cytotoxic chemotherapy, radiation, or surgery. The composition has the advantages of rapid absorption and onset of action, prolonged drug plasma concentration and pharmacological effects comparable to intravenous infusion, as well as reduced nasal stinging sensation.

Abstract: Disclosed are hydrogel composition, method for preparing the same and use thereof. The hydrogel composition comprises a guar gum derivative which is crosslinked, a mint-based component, water, and optionally, an amphiphilic core-shell nanoparticle having a hydrophobic core and a hydrophilic shell, wherein the amount of the mint-based component is in the range of 1-6 wt % and the amount of the water is in the range of 65-95 wt %, based on the total weight of the hydrogel composition. The hydrogel composition is safe and can provide symptomatic relief for patients with symptoms such as severe and intractable pruritus associated with hypertrophic scars. The symptomatic relief effect of the hydrogel composition is reproducible, and is independent of the etiology of the burn trauma, extent of the scarring and duration of the scar formation, while tachyphylaxis is not observed. Also disclosed is a medical device comprising the hydrogel composition.

Abstract: In a gel-like mass having natural or synthetic polymers, preferably polygalactomannans, at least one cross-linking agent and further ingredients, according to this invention that the at least one cross-linking agent is of amphiphilic core-shell nanoparticles. This invention further refers to a method for producing a gel-like mass, a composition for producing a gel-like mass comprising natural or synthetic polymers, preferably polygalactomannans and amphiphilic core-shell nanoparticles and the use of a gel-like mass as drug delivery system for topical medication.

Abstract: The present invention is directed to an ophthalmic composition, method for preparing the same, and use of the same. The ophthalmic composition includes a mixture of lipid nano-dispersion and gel substrate, wherein the lipid nano-dispersion includes a first lipid, a second lipid, and emulsifier; in which the first lipid exists in form of solid lipid as staring material, and the second lipid exists in form of liquid lipid as staring material. The ophthalmic composition can better reduce the symptoms of dry eye, and is safe, convenient and economical to use, and can be used during daytime without blocking of vision.

Abstract: In a gel-like mass having natural or synthetic polymers, preferably polygalactomannans, at least one cross-linking agent and further ingredients, according to this invention that the at least one cross-linking agent is of amphiphilic core-shell nanoparticles. This invention further refers to a method for producing a gel-like mass, a composition for producing a gel-like mass comprising natural or synthetic polymers, preferably polygalactomannans and amphiphilic core-shell nanoparticles and the use of a gel-like mass as drug delivery system for topical medication.

Abstract: In accordance with the invention, with an eye swab for cleaning eyes of vertebrate animals, for example dog's eyes, is provided. The eye swab consists of a gel-like putty, wherein the gel-like putty is held together from a reversibly bonded, three-dimensional network formed of at least one natural or synthetic polymer, at least one cross-linking agent and glycerol.

Abstract: An oral meclizine aqueous formulation is disclosed. The oral meclizine aqueous formulation comprises a solubizier for enhancing aqueous solubility of meclizine, and a taster flavoring agent selected from the group consisting of sugar, sucrose, sorbitol, sucralose, saccharin sodium, sodium cyclamate, aspartame, neotame, acesulfame potassium, stevioside, and their mixtures. Preferably the solubilizer is hydroxypropyl-?-cyclodextrin or polyethylene glycol 660 13-hydroxystearate. The oral meclizine aqueous formulation can provide a rapid onset of therapeutic effects of meclizine.