Abstract: Provided herein are gene repressor systems comprising fusion proteins, such as fusion proteins comprising a DNA binding domain such as a TALE, zinc finger or catalytically-dead CRISPR protein and guide nucleic acid (gRNA), which are useful in the repression of a proprotein convertase subtilisin kexin Type 9 (PCSK9) gene. Also provided are methods of using such systems to repress transcription of PCSK9.

Abstract: Provided herein are gene repressor systems comprising fusion proteins, such as fusion proteins comprising a DNA binding domain such as a TALE, zinc finger or catalytically-dead CRISPR protein and guide nucleic acid (gRNA), which are useful in the repression of a proprotein convertase subtilisin/kexin Type 9 (PCSK9) gene. Also provided are methods of using such systems to repress transcription of PCSK9.

Abstract: A method and system are provided to facilitate the commissioning of a distributed system. The method and system obtains a base configuration which defines an expected virtual topology for a distributed system, and identifies via a control device a physical network topology of the distributed system to commission the distributed system. The control device performs network discovery to identify a plurality of connected devices that are communicatively coupled thereto, and to collect device information for each connected device relating to its identity and relative position in the distributed system which has connected devices or associated subnetworks connected in a ring network topology. The collected device information for the plurality of connected devices is compared to the expected virtual topology from the base configuration to determine an identity and physical location of the plurality of connected devices and associated subnetworks in the physical network topology of the distributed system.

Abstract: The present invention provides vaccine compositions and methods of producing such compositions. Other embodiments of the invention include methods of treating a pathogen infection, methods of vaccinating a subject against a pathogen infection, and methods for treating an antibiotic-resistance bacterial infection in a subject in need thereof. In further embodiments, the invention includes methods of decreasing the level of a pathogen in a subject having a pathogen infection, methods of increasing the surviving rate of a subject having a pathogen infection, methods of reducing the level of pain associated with a pathogen infection, and methods of reducing the level of distress associated with a pathogen infection in a subject in need thereof. Novel scaffold compositions and opsonin-bound or lectin-bound pathogen compositions, and uses thereof, are also provided herein.

Abstract: A transient pressure event detection system and method for a pipeline network are disclosed. The system includes a data repository encoding route data on the pipeline network, a data receiver configured to receive timestamped pipeline sensor data from each of a plurality of sensors that are spaced apart in the pipeline network, use the sensor data received to identify a transient pressure event occurrence and the timestamp for the event occurrence's arrival time, determine routes in the pipeline network between the sensors, for each route determine a potential source location in the pipeline network for the transient pressure event, perform a simulated transient event for each potential source location and determine a modelled arrival time of a transient corresponding to the event, compare the timestamp of the event occurrence with the modelled arrival time and select the potential source location corresponding to the closest modelled arrival time.

Abstract: Systems and methods for transforming and navigating historical map images are presented. The systems and methods embodiments facilitate providing, searching for, retrieving, transforming, and/or navigating a historical map image vis-à-vis a modern location and/or map. A map interface facilitates automatedly overlaying, annotating, and aligning a historical map image(s) with a modern map, allowing a user to search for a location and see the same in the historical map image, and change a visibility of the overlaid and aligned map images relative to each other. The map interface provides user interactions that facilitate retrieving, viewing, and manipulating records, historical districts, and other pertinent data through interacting with a particular location and/or searched-for individual, such as an ancestor or other person of interest.

Abstract: The present invention concerns a complex comprising an active agent, a polymer and an iron oxide nanoparticle. The complex may also comprise an active agent. Also described are methods of releasing an active agent from the complex, for instance by irradiating the complex with radio waves. Also described are compositions and articles comprising the complex. Also described are methods of therapy and particularly methods of treatment of cancer involving the complex described herein. In addition, the invention concerns a polymer which is particularly useful in preparing the complex described herein. The polymer is capable of undergoing a phase change at a predetermined temperature, such as 39-42° C. In one embodiment, the polymer is a copolymer of N-isopropylacrylamide, acrylic acid and acrolein. In another embodiment, the polymer is a copolymer of N-isopropylacrylamide acrylamide and allyl mercaptan.

Abstract: A computing server may receive genealogical records that include historical records of deceased individuals. The computing server may normalize the genealogical records into normalized genealogical records. Normalizing the genealogical records may include converting a text string of a genealogical record into a standardized format. The computing server may stitch the normalized genealogical records into a plurality of clusters. Each cluster corresponds to an individual and includes one or more genealogical records associated with the individual. The computing server may identify a life-event record that is commonly associated with a subset of clusters, the life-event record indicating that a plurality of deceased individuals are connected through a non-familial relationship in a life event documented by the life-event record.

Abstract: A system for controlling an impedance matching circuitry can include an antenna, a receiving or transmitting circuitry, an impedance matching circuitry, a circuitry, and a controller. The impedance matching circuitry can be coupled between the antenna and the receiving or transmitting circuitry. The circuitry can be configured to set a value of an impedance of the impedance matching circuitry. The controller can be configured to determine, based on a state of an electronic device, that the electronic device is configured to perform one or more functions with one or more of a satellite radio navigation signal at a first or a second frequency, a wireless local area network signal at a third or a fourth frequency, or a personal area network signal at a fifth or a sixth frequency. The controller can be configured to control, in response to a determination of the state of the electronic device, the circuitry.

Abstract: This disclosure describes a market segment analysis (MSA) system that facilitates a cluster analysis of market segment data and performance metrics to identify data patterns between individual market segments within a designated market region. Particularly, the MSA system may quantify current performance of existing vendor product or service offerings within a market segment relative to historical performance of the vendor product or service offering within the market segment. Further, the MSA system may quantify current performance of a vendor product or service offering relative to current peer performance of the same or substantially similar vendor product or service offerings within additional market segments. The MSA system may recommend one or more additional market segments for an offering of the vendor product or service. Alternatively, or additionally, the MSA system may recommend one or more vendor product or service offering(s) for a target market segment of a designated market region.

Abstract: This disclosure describes a market segment analysis (MSA) system that facilitates a cluster analysis of market segment data and performance metrics to identify data patterns between individual market segments within a designated market region. Particularly, the MSA system may quantify current performance of existing vendor product or service offerings within a market segment relative to historical performance of the vendor product or service offering within the market segment. Further, the MSA system may quantify current performance of a vendor product or service offering relative to current peer performance of the same or substantially similar vendor product or service offerings within additional market segments. The MSA system may recommend one or more additional market segments for an offering of the vendor product or service. Alternatively, or additionally, the MSA system may recommend one or more vendor product or service offering(s) for a target market segment of a designated market region.

Abstract: A snubbing jack including a jack assembly including a base plate, a traveling plate, an axis extending through the base plate and the traveling plate, and a plurality of piston-cylinder assemblies, a rotary drive including a rotary base and a hub, wherein the rotary drive is configured to rotate the hub relative to the rotary base, a clamp coupled to the rotary base and configured to grip a first tubular member, a power tongs coupled to the rotary base and configured to grip a second tubular member and to rotate the second tubular relative to the rotary base, and a torque transfer device coupled between the rotary drive and the jack assembly and configured to allow the rotary drive to move axially relative to the base plate and configured to restrict rotation of the rotary drive relative to the jack assembly.

Abstract: A snubbing jack including a jack assembly including a base plate, a traveling plate, an axis extending through the base plate and the traveling plate, and a plurality of piston-cylinder assemblies, a rotary drive including a rotary base and a hub, wherein the rotary drive is configured to rotate the hub relative to the rotary base, a clamp coupled to the rotary base and configured to grip a first tubular member, a power tongs coupled to the rotary base and configured to grip a second tubular member and to rotate the second tubular relative to the rotary base, and a torque transfer device coupled between the rotary drive and the jack assembly and configured to allow the rotary drive to move axially relative to the base plate and configured to restrict rotation of the rotary drive relative to FIG.

Abstract: A hinged structure includes a hinge that is actuatable using a hydraulic cylinder. A method of monitoring a load applied to the hinged structure involves leaking the hydraulic fluid from the hydraulic cylinder in a way that compensates for expansion of the hydraulic fluid caused by variations in temperature of the hydraulic fluid. The method further involves measuring the pressure of the hydraulic fluid in the hydraulic cylinder. The hydraulic cylinder may be part of a coiled tubing injector. The load applied to the hydraulic cylinder may be used to indicate an overload of the tubing guide.

Abstract: There is provided to a path following arrangement having a catenary structure and a method for operating such an arrangement. The path following arrangement permits a ride participant or a passenger to traverse tracts of land having a relatively wide range of scenic variety in that the path of travel can include linear portions and non-linear (change of direction) portions.

Abstract: An example unmanned aerial vehicle includes an electromagnetic radiation (EMR) sensor. The EMR sensor detects a signal indicative of a direction of emission of the signal. The unmanned aerial vehicle also includes a nozzle to eject the substance based on the direction of emission.

Abstract: An apparatus for combining cognitive reasoning and physical movement includes a plurality of modular elements, receiving elements, inserts, and instructions. The plurality of modular elements are adjoined together defining a body having an upper, first side and an opposing bottom, second side. The receiving elements are disposed on at least a first side of each modular element and are configured to hold the inserts. The inserts are removable and interchangeable and include indicia. The instructions are for using the apparatus to combine cognitive reasoning and physical movement.

Abstract: A hinged structure includes a hinge that is actuatable using a hydraulic cylinder. A method of monitoring a load applied to the hinged structure involves leaking the hydraulic fluid from the hydraulic cylinder in a way that compensates for expansion of the hydraulic fluid caused by variations in temperature of the hydraulic fluid. The method further involves measuring the pressure of the hydraulic fluid in the hydraulic cylinder. The hydraulic cylinder may be part of a coiled tubing injector. The load applied to the hydraulic cylinder may be used to indicate an overload of the tubing guide.

Abstract: This disclosure describes a market segment analysis (MSA) system that facilitates a cluster analysis of market segment data and performance metrics to identify data patterns between individual market segments within a designated market region. Particularly, the MSA system may quantify current performance of existing vendor product or service offerings within a market segment relative to historical performance of the vendor product or service offering within the market segment. Further, the MSA system may quantify current performance of a vendor product or service offering relative to current peer performance of the same or substantially similar vendor product or service offerings within additional market segments. The MSA system may recommend one or more additional market segments for an offering of the vendor product or service. Alternatively, or additionally, the MSA system may recommend one or more vendor product or service offering(s) for a target market segment of a designated market region.