Abstract: A method includes storing data in a knowledge graph stored in a database. The knowledge graph is defined by nodes connected by edges, in which a root node of the knowledge graph is connected to a first version node by a first edge. The root node represents a data asset, and the first version node represents a first version of the data asset. A status indicator associated with the first version node has a first state indicating that the first version of the data asset is an editable draft version of the data asset. Responsive to receiving an instruction to publish the first version of the data asset, the state of the status indicator is changed to a second state that indicates that the first version of the data asset is a published version of the data asset.

Abstract: This invention provides a system and method to propagate uncertainty information in a deep learning pipeline. It allows for the propagation of uncertainty information from one deep learning model to the next by fusing model uncertainty with the original imagery dataset. This approach results in a deep learning architecture where the output of the system contains not only the prediction, but also the model uncertainty information associated with that prediction. The embodiments herein improve upon existing deep learning-based models (CADe models) by providing the model with uncertainty/confidence information associated with (e.g. CADe) decisions. This uncertainty information can be employed in various ways, including (a) transmitting uncertainty from a first stage (or subsystem) of the machine learning system into a next (second) stage (or the next subsystem), and (b) providing uncertainty information to the end user in a manner that characterizes the uncertainty of the overall machine learning model.

Abstract: A handheld radiation delivery system is disclosed that includes a two-part delivery module comprising a reusable portion that contains a radioactive source wire and a disposable portion that includes a drive assembly for moving the radioactive source wire between storage and treatment positions. A disposable applicator tip is provided that includes a cannula for receiving the radioactive source wire when in the treatment position and a mechanism for limiting the number of uses of the device. A handheld cable actuator is operatively connected to the disposable portion of the handpiece to impart motion to the source wire.

Abstract: A handheld radiation delivery system is disclosed that includes a two-part delivery module comprising a reusable portion that contains a radioactive source wire and a disposable portion that includes a drive assembly for moving the radioactive source wire between storage and treatment positions. A disposable applicator tip is provided that includes a cannula for receiving the radioactive source wire when in the treatment position and a mechanism for limiting the number of uses of the device. A handheld cable actuator is operatively connected to the disposable portion of the handpiece to impart motion to the source wire.

Abstract: Methods and apparatus for intraocular brachytherapy are disclosed in which a cannula is introduced into the eye for delivery of radiation to a target tissue. Techniques for properly locating the cannula with respect to the target tissue, for protecting non-target tissue, for regulating heat generated by x-ray emitters, and for combining therapies are disclosed.

Abstract: A system includes a light source operable to generate light energy for a cornea reshaping procedure. The system also includes a device operable to be attached to an eye having a cornea. The device includes a window operable to contact at least a portion of the cornea. The window is substantially transparent to the light energy that irradiates the cornea during the cornea reshaping procedure. The window is also operable to cool at least a portion of a corneal epithelium in the cornea during the cornea reshaping procedure. The window may be operable to prevent clinically significant damage to the corneal epithelium during the cornea reshaping procedure. The window may be operable to prevent a temperature of the corneal epithelium from exceeding a damage threshold temperature during the cornea reshaping procedure, such as a damage threshold temperature of approximately 70° C.

Abstract: A system for supplying optical power uses an optical switch or shutter at the handpiece. The optical switch is positioned between an open light-transmitting position and a closed light-reflecting position. A detector at the base of the system can be used to detect the position of the optical shutter in some situations. This can be used to control the operation of a high-intensity light source. In this manner, the system can be controlled at the handpiece without using electrical power at the handpiece.